Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?
Hepatitis B virus (HBV) replication and persistence are sustained by a nuclear episome, the covalently closed circular (CCC) DNA, which serves as the transcriptional template for all viral RNAs. CCC DNA is converted from a relaxed circular (RC) DNA in the virion early during…
DOI: 10.1371/journal.pone.0128401