273
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
COMPARATIVE QUALITY CONTROL AND STANDARDIZATION OF
DICLOFENAC-CONTAINING MEDICINAL PRODUCTS IN TABLET FORM
Shodmono a M.Z.
Rasulo .F.B.
Andijan S a e Medicine Ins i u e, Andijan ci y, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17334184
Rele ance: Diclo enac sodium and diclo enac po assium sal s o in lamma ion agains , pain
lea e and an ipy e ic ea u es because o medicine in p ac ice wide applicable d ugs o he poin
They a e a h i is, heuma ism, neu algia, muscles and in he join s he pains in educ ion p ima y
om ools is conside ed. On he ma ke local and o eign wo king issue s by wo king issued one ow
diclo enac pills Howe e , he e a e a ious wo king issue s p oduc s quali y, s abili y and
bioequi alence acco ding o di e ences obse a ion possible. The e o e hem compa a i e quali y
con ol o do, s a e pha macopoeia equi emen s compa ibili y de e mina ion and s anda diza ion
d ugs sa e y and e iciency in p o iding impo an impo ance has.
The esea ch Pu pose: Va ious wo king issue s by wo king issued pill shaped diclo enac
sa ed medicine o ools quali y indica o s compa a i e e alua ion, hei o s anda ds compa ibili y
check and he e is sho comings o de e mine.
Me hod and Me hods: In esea ch local and o eign wo king 5 ypes o issue s diclo enac pills
s udied. In he samples ollowing indica o s checked:
- Ex e nal Appea ance: able s colo , shape and in eg i y.
- A e age weigh and weigh de ia ion: 20 uni s on a able con ol - Disin eg a ion
Time: Uzbekis an Republic S a e pha macopoeia equi emen s app op ia e special in he appa a us
e alua ed.
- Mechanic consis ency: able s agili y and c ushing le el iden i ied, anspo and in s o age
s abili y - Solubili y (dissolu ion) a e:
a i icial s omach juice and neu al in he en i onmen s udied.
- Quan i a i e analysis: spec opho ome y me hod using in he pill diclo enac amoun
de e mined, de ined no ma i e indica o s wi h compa ed.
Resul s: T ans e ed inspec ions his showed ha :
- Some local wo king issue s in samples decomposi ion ime om he no m a li le mo e han
i happened, his and medicine o he impac o slow down ake a i al possible.
- Solubili y speed acco ding o o eign wo king issue s pills mo e s able esul showed, local
wo king in issue s and some low sco es in se ies obse ed.
- Quan i a i e analysis in he esul s some in able s ac i e subs ance quan i y be ween 95–98%
while in o he s i is be ween 100–105% de e mined and s anda dized comple e sui able did no come.
- Mechanic s eng h in e ms o o eign d ugs highe o indica o s has became, local in p oduc s
and agili y highe du ing he anspo a ion p ocess o pills c ushing p obabili y big ha is obse ed
Conclusion: Resea ch o he esul s acco ding o, diclo enac sa ed o pills quali y indica o s
wo king o he issue looking a no iceable a he le el di e ence does. Fo eign p epa a ions many
pa ame e s acco ding o high quali y indica o s has al hough some local wo king issue s p oduc s a e
also pha macopoeia equi emen s comple e answe ga e. Wi h ha oge he , local wo king issue s
o echnological p ocesses imp o emen , quali y con ol s eng hen and in e na ional o s anda ds
coo dina ion acco ding o ecommenda ions wo king exi necessa y.
