Co esponding au ho : Zaka yaa Salma
Copy igh © 2025 Au ho (s) e ain he copy igh o his a icle. This a icle is published unde he e ms o he C ea i e Commons A ibu ion Liscense 4.0.
Ra e p esen a ion o Lucie F ey synd ome a e igeminal he pes zos e
Fouzia Hali, Salma Zaka yaa * and Soumiya Chiheb
Depa men o De ma ology and Vene eology, Ibn Rochd Uni e si y hospi al, Hassan II Uni e si y, Casablanca.
Wo ld Jou nal o Ad anced Resea ch and Re iews, 2025, 26(02), 147-149
Publica ion his o y: Recei ed on 18 Ma ch 2025; e ised on 29 Ap il 2025; accep ed on 01 May 2025
A icle DOI: h ps://doi.o g/10.30574/wja .2025.26.2.1543
Abs ac
Lucie F ey Synd ome, o "gus a o y swea ing," is a a e au onomic neu opa hy caused by abe an pa asympa he ic
einne a ion ollowing ne e damage. While commonly associa ed wi h auma ic o su gical e iologies, in ec ious
causes such as he pes zos e a e excep ionally a e in pedia ic cases. We epo he case o a 3-yea -old emale who
de eloped unila e al e y hema and ocal hype hid osis on he igh hemi ace.
Keywo ds: Lucie F ey Synd ome; Gus a o y Swea ing; He pes Zos e ; Pedia ic Au onomic Neu opa hy; Abe an
Ne e Regene a ion
1. In oduc ion
Lucie F ey Synd ome, o "gus a o y swea ing," is an uncommon au onomic neu opa hy esul ing om abe an
pa asympa he ic einne a ion ollowing ne e damage. While ypically associa ed wi h auma ic o su gical e iologies
in adul s, in ec ious o igins, such as he pes zos e , emain excep ional in pedia ic cases.
2. Case p esen a ion
We epo he case o a 3-yea -old emale pa ien wi h a his o y o he pes zos e in ol ing he igh hemi ace, ea ed
success ully wo yea s p io . She de eloped unila e al episodes o e y hema and ocal hype hid osis a ec ing he igh
cheek, igge ed by ood in ake o chewing. These episodes, which esol ed spon aneously wi hin minu es, we e
objec i ely con i med ia a p o oca ion es using sal y oods. Comp ehensi e o ola yngologic e alua ions, including
hinoscopy, compu ed omog aphy (CT) o he ace, and so issue ul asonog aphy, e ealed no abno mali ies.
A diagnosis o Lucie F ey Synd ome was made based on he pa ien ’s clinical his o y, he cha ac e is ic opog aphy o
symp oms, and he posi i e p o oca ion es (Figu e 1).
This diagnosis unde sco es a a e in ec ious e iology in he pedia ic age g oup. Symp oma ic managemen was ini ia ed
wi h he applica ion o opical an icholine gics, speci ically oxybu ynin c eam, o mi iga e hype hid osis. Addi ionally,
bo ulinum oxin injec ions a e planned o p o ide sus ained con ol o symp oms.
Wo ld Jou nal o Ad anced Resea ch and Re iews, 2025, 26(02), 147-149
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Figu e 1 Clinical aspec o he pa ien a e P o oca ion Tes : Hype hid osis and E y hema o he Righ Cheek
3. Discussion
Lucie F ey Synd ome, also e e ed o as "gus a o y swea ing," ep esen s a unique challenge o de ma ologis s due o
i s a e p esen a ion and unde lying au onomic neu opa hology. This condi ion, esul ing om abe an
pa asympa he ic einne a ion, is p ima ily ecognized in adul s ollowing su gical o auma ic inju y o he
au iculo empo al ne e. Howe e , he pedia ic occu ence o his synd ome, pa icula ly wi h an in ec ious e iology
such as he pes zos e , emains exceedingly a e and clinically signi ican (1).
F om a de ma ological pe spec i e, he symp oms—episodic e y hema and ocal hype hid osis—p esen clea -cu
diagnos ic cues. In his case, he de ma ological mani es a ion o unila e al lushing and swea ing on he igh cheek,
consis en ly igge ed by ood in ake, unde sco es he ole o gus a o y s imuli in he ac i a ion o abe an ly
egene a ed pa asympa he ic ibe s. De ma ologis s mus be a uned o such p esen a ions, pa icula ly in pa ien s wi h
a p io his o y o he pes zos e o o he c anial ne e inju ies (2).
The con i ma ion o Lucie F ey Synd ome in ou pa ien elied on a s uc u ed de ma ologic e alua ion, including a
p o oca ion es wi h sal y oods o objec i ely ep oduce symp oms. Ad anced imaging modali ies helped exclude
o he po en ial causes o acial e y hema and hype hid osis, ea i ming he need o de ma ologis s o employ a
mul idisciplina y app oach in complex cases (3).
Managemen in his case in ol ed opical applica ion o oxybu ynin c eam, an an icholine gic ha ac s by inhibi ing
swea gland ac i a ion. This app oach e lec s a de ma ologically ele an s a egy o mi iga ing symp oms o localized
hype hid osis.
Fo mo e sus ained con ol, bo ulinum oxin injec ions a e planned. Bo ulinum oxin he apy is a co ne s one in he
de ma ologic managemen o ocal hype hid osis, o e ing p olonged elie by blocking ace ylcholine elease a he
Wo ld Jou nal o Ad anced Resea ch and Re iews, 2025, 26(02), 147-149
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neu omuscula junc ion o swea glands (4, 5). De ma ologis s should emain igilan abou hese he apeu ic op ions,
ailo ing ea men s o indi idual pa ien needs.
This case is a a e pedia ic p esen a ion o Lucie F ey Synd ome wi h an in ec ious e iology ha unde sco es he
impo ance o ecognizing he de ma ologic sequelae o pos -in lamma o y au onomic neu opa hies and p o ides
insigh s in o diagnos ic echniques and ea men modali ies. I also exempli ies he in ica e in e play be ween
de ma ologic symp oms and unde lying neu opa hology, encou aging u he explo a ion in o a ge ed he apies o
his a e condi ion.
4. Conclusion
This case epo adds o he de ma ologic li e a u e by highligh ing a a e p esen a ion o Lucie F ey Synd ome wi h an
in ec ious e iology ollowing igeminal he pes zos e in a pedia ic pa ien . The unique clinical indings, diagnos ic
p ocess, and managemen s a egies ou lined in his case emphasize he impo ance o ecognizing au onomic
neu opa hies in he con ex o pos -in lamma o y ne e lesions. By documen ing his unusual p esen a ion, we aim o
con ibu e o he g owing unde s anding o his condi ion and in o m u u e clinical p ac ice
Compliance wi h e hical s anda ds
Disclosu e o con lic o in e es
No con lic o in e es o be disclosed.
S a emen o in o med consen
In o med consen was ob ained om he pa icipan included in he s udy.
Re e ences
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