NFDI4Microbiota - The German National Research Data Infrastructure for the Research of Microbiota

Author: Thölken, Clemens; Vockenhuber, Michael-Paul

Publisher: Zenodo

DOI: 10.5281/zenodo.17293563

Source: https://zenodo.org/records/17293563/files/2025-10-08-NFDI4Microbiota-NFDI_Defense_Poster-v3.pdf

NFDI4Mic obio a - The Ge man Na ional Resea ch
Da a In as uc u e o he Resea ch o Mic obio a
Rep esen ed by Alice C. McHa dy, Alexande Goesmann, Manja Ma z, Alexande Sczy ba, Kon ad U. Fö s ne
unde he Na ional Resea ch Da a In as uc u e
NFDI 28/1 P ojec numbe 460129525
Ea h/Clima e
Ag icul u e
Food P oduc ion
Bio echnology
Pha maceu ics
Human
well-being
Flag ship se ices
C i ical Assessmen o
Me agenome In e p e a ion
The Cloud-based
Wo kﬂow Manage
Mic obial s ain
iden iﬁe -se ice
Vi us me ada a, and
sequence esou ce
Dis ibu ed cloud da a
o ches a ion solu ion
NFDI4Mic obio a is a s ong
con ibu o o Base4NFDI
In e na ional collabo a ions
T aining
pa icipan s
>2300
T aining
e en s
> 190
9
P oduc i e
use
cases
> 300
Communi y
engagemen s
15
Use case
collabo a ing
ins i u ions
Vision
Resea che s can ansla e da a easily
in o a deep unde s anding o mic obial
o ganisms and hei in e ac ions on a
molecula le el.
Mission
Be he cen al hub in Ge many o
suppo ing he mic obiology communi y
wi h da a access, analysis se ices,
da a/me ada a s anda ds and aining.
Communi y & Se ices
Scaling in o he communi y
Challenges
Impac
Fo example:
- Bioin o ma ical ools
including exac e sion
- Dependencies
- Re e ence da a
(genomes)
Fo example:
- Media composi ion
- pH alue
- Tempe a u e
- Geo loca ion
- Sample dep h
Fo example:
- Machine ype
- Vendo
- Fi mwa e e sion
- Run pa ame e s
S o age
Collec ion o echnical and biological me ada a
Knowledge base and aining
Consul a ion / Helpdesk
Elec onic lab
no ebooks (ELNs) Da a quali y con ol
S anda d ope a ing p ocedu es (SOPs)
Da a bases and
knowledge g aphs
Da a managemen
plans (DMPs)
S udy design Da a
gene a ion Da a analysis
Publica ion / submission
o da a / code / models
o eposi o ies
(ENA/SRA/Zenodo e c.)
NFDI4Mic obio a Se ices
Expe imen s High h oughpu
me hods
Example use case: Me aP o - Func ional p oﬁling
and ou ine diagnosis o humane mic obiomes by
me ap o eomics
Me ap o eomics enables in-dep h mic obiome analysis, especially
in he human gu , using LC-MS/MS o cha ac e ize axonomic and
unc ional composi ion. P o ein abundance eﬂec s ac i i y and
can de ec hos o en i onmen al p o eins.
Use Case Me aP o ocuses on s anda diza ion and da a in eg a ion by:
- De eloping a cu a ed human gu mic obiome p o ein da abase
- C ea ing a ool o me ada a anno a ion and s anda dized ﬁle con e sion
4000
Compu e
co es
350
TB
s o age
500
TB
objec
s o age
P ojec s
> 200
TB
esea ch
da a
> 38
>40
Cu a ed
bes p ac ice
wo kﬂows
Achie emen s
Highligh s o he nex unding phase
LEAD USE CASE
RDMT4 PID4
LEAD INCUBATOR
KGI4 IAM4
MEMBER USED IN
TRAINING
DMP4 Jupy e 4
EXCHANGE
TS4
LEAD
MC4
USER /
CONTRIBUTOR
so wa e
USER /
CONTRIBUTOR
DALIA4
Taylo ed aining p og ammes o collabo a ing
esea ch ne wo ks and insi u ions
Lab FAIR p ac icies
Ea ly me ada a cap u ing and in eg a ion
o da a gene a ion acili ies
This pos e is deposi ed
a Zenodo unde he DOI:
10.5281/zenodo.14810222
In eg a ion ia he Li e Science Resea ch
Node in o he Eu opean Open Science Cloud
Resea ch
Wo kﬂow
Resou ce equi emen s o NFDI in e nal
in e ac ions (Sec ions & Base4NFDI)
Seamless in eg a ion in he e ogeneous
esea ch en i onmen s
O e a ching Knowlege G aph
Poli ical consul ing & legal amewo ks
ega ding digi al sequence in o ma ion (DIS)
Expanded suppo o euka yo ic species
(e.g. wi h he Mic obeDi e DB)
Gene a ing me ada a using
AI solu ions
Imp o ing (me a)da a o be e
model aining (AI eadiness)
Deepe collabo a ion and consolida ion wi h conso ia
in he BioMed and he Bioda a in e es g oups
C ea ing p i acy sensi i e da a p ocessing
and secu e p ocessing en i onmen s
§
+
Fungi
Vi uses
A chaea
P o is s
Pa asi es
Bac e ia
Vi uses
Mic obial
Communi ies
13
Resea c
h
Cons
o
ia
EXC 2051
EXC 2124
EXC 2155
SFB 1182
SFB 1371
SFB 1382
SFB 1583
SFB 2330
SPP 2474
F aunho e CIMD
Global Mic obiome
Conse ancy
Mic obes o Clima e
Resea ch Cen e One
Heal h Ruh
>60
P
a
ic
i
pan
s
7
Assoc
i
a i
o
ns
VAAM
G V
DGHM
DGP
DG M
DMykG
EuMik
10
(Co-)Ap
p
li
c
an
s
Uni e si ies
Resea ch
Ins i u es
Plön
Jena
Leipzig
Be lin
P
o sdam
Essen
Aachen
Mün
c
hen
Heide
l
be g
K
öln
E la
n
gen
Biele eld
W
ü
z
bu
g
Ma
bu
g
Gießen
Kiel
B
emen
Jülich
B au
n
sc
h
weig
Hanno e
K
a ls
u
he
Bonn
Hambu
g
Da
ms ad
F
an
k
u
Tübingen
S u ga
Regensbu g
Do mund
Wuppe al
Kö hen
Saa b ücken

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