Ti le:
Associa ion o echoca diog aphic adiomics-based ea u es wi h ca dio oxici y e ec in
b eas cance pa ien s om he CARDIOCARE p ojec
Au ho s:
G. Manikis, G. Kallia akis, K. Ma ias, V. Bou a zis, L. Lakkas, A. Naka, G. Ka anasiou, D.
Tsekou a, E. Kampou oglou, K. Ke amida, A. Papakons an inou, A. Cons an inidou, K.
Mazzocco, C. Cipolla, D. Fo iadis
A ilia ions:
1. Founda ion o Resea ch and Technology - Hellas, He aklion, G eece
2. Uni e si y hospi al o Ioannina, Ioannina, G eece
3. Uni e si y o Ioannina, Ioannina, G eece
4. A e aieio Hospi al, A hens, G eece
5. A ikon Uni e si y Hospi al, A hens, G eece
6. Ka olinska Ins i u e , S ockholm, Sweden
7. Uni e si y o Cyp us, Nicosia, Cyp us
8. Uni e si y o Milan, Milan, I aly
9. Eu opean Ins i u e o Oncology, Milan, I aly
On behal o CARDIOCARE EU p ojec
Manusc ip :
The manusc ip explo es he associa ion be ween echoca diog aphic adiomics-based
ea u es and ca dio oxici y in b eas cance pa ien s om he CARDIOCARE p ojec .
Imp o emen s in b eas cance he apy ha e led o inc eased su i al, bu also mo e
ca dio oxic e ec s like ca diomyopa hy and hea ailu e. The s udy aims o le e age
adiomics analysis o non-in asi e echoca diog aphy bioma ke s associa ed wi h
ca dio oxici y. In a p ospec i e coho o 28 pa ien s (abo e 60 yea s old, 10 de eloped
ca dio oxici y) unde going an ineoplasma ic he apy, o e 1500 imaging ea u es we e
ex ac ed om echoca diog aphic images (apical 4- and 2-chambe iews) a baseline
and a e 3 mon hs using a p e- ained neu al ne wo k o segmen a ion. Ca dio oxici y
was assessed by combining imaging (LVEF, GLS) and blood ma ke s (T oponin I, N -p o-
Bnp). Uni a ia e analysis showed 40 ex u al adiomics ea u es (mos ly om he
myoca dium, especially in he 4-chambe end-dias olic iew and 2-chambe end-
sys olic iew) we e signi ican ly associa ed wi h ca dio oxici y, while his og am and
shape ea u es we e no . The s udy concludes ha myoca dial he e ogenei y quan i ied
by adiomics could ha e diagnos ic alue o ea ly de ec ion o ca diac oxici y.
