69
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
DEVELOPMENT OF A METHOD FOR OBTAINING A DRUG USED IN
UROLITHIASIS
Rakhimo a G.R.1
Sha ipo a S.T.2
Rakhimo a O.R.3
Azimo a N.A.4
Tashken Pha maceu ical Ins i u e, Tashken ci y, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17318636
Acco ding o he Wo ld Heal h O ganiza ion (WHO), he bal medicines accoun o a signi ican
po ion o he pha maceu ical indus y. A signi ican po ion o he popula ion o de eloping coun ies
uses adi ional na u al medicines as pa o he p ima y heal h ca e sys em. The lack o clea c i e ia
and me hods o e alua ing he bal medicines has led o he ac ha bo h medicines and die a y
supplemen s a e cu en ly p oduced om he same ype o aw ma e ial. Fo he ull use o he bal
medicines in medical p ac ice, i is necessa y o clea ly unde s and he ac ha s anda diza ion o
medicinal plan ma e ials and imp o emen o quali y con ol me hods o he bal medicines is he
mos impo an condi ion o hei e ec i e use. The main collec ion o egula o y documen s on
medicines a e he S a e Pha macopoeias o indi idual coun ies o Eu ope, which con ain gene al
a icles on s anda diza ion o medicines and monog aphs on he use o indi idual ypes o aw
ma e ials o plan o igin. Ce ain di icul ies a ise du ing he s anda diza ion o he bal medicines. I
is necessa y o use mode n physicochemical me hods o hei analysis. Such me hods, wi h he
app op ia e deg ee o selec i i y, accu acy, a ailabili y o implemen a ion in indus ial p oduc ion,
a e op ical and elec ochemical me hods o analysis in combina ion wi h a ious ypes o
ch oma og aphy. In ecen yea s, spec opho ome ic me hods ha e become widesp ead in
de e mining he composi ion o he bal medicines, allowing o a high deg ee o accu acy in
de e mining he quali a i e and quan i a i e cha ac e is ics and iden i ying indi idual componen s in
o al he bal p epa a ions, as well as in he o iginal ypes o aw ma e ials. As a ule, he chemical
componen s o plan s a y depending on he species, a ie y and pa o he plan , g owing condi ions
(soil, humidi y, empe a u e), season and age o he plan . These di e ences make he s anda diza ion
o ac i e ing edien s e y impo an , bu his p ocedu e is complex and no always a ailable.
T adi ional medicine conside s madde as a plan wi h an ispasmodic and diu e ic p ope ies.
T adi ional heale s ecommend aking he ex ac o a numbe o se ious diseases, including gou ,
ube culosis and e en oncology. The na u al chemical composi ion o he aw ma e ial and he na u al
combina ion o an h aquinones wi h subs ances o o he g oups a e o alue o pha macology. The
s onges pha macological ac ion is p o ided by madde ex ac . The e o e, i is used as a sepa a e
d ug, and also in oduced in o he composi ion o o he medicines. A p esen , in he Russian
Fede a ion, madde ex ac able s o 250 mg a e p oduced and used. Due o he impe ec ion o he
me hods o he quan i a i e de e mina ion o an h acene de i a i es in he S a e Pha macopoeia o
he Russian Fede a ion o he XIV edi ion, he Eu opean Pha macopoeia, a s udy was conduc ed o
subs an ia e new me hodological app oaches o he s anda diza ion o he amoun o an h acene
de i a i es in madde . This s udy examined he possibili y o using simila me hods o de e mining
he amoun o an h acene de i a i es in madde ex ac able s. Resul s. The e a e se e al ways o
ob ain an alcohol ex ac o madde o making a inc u e: by mace a ion o pe cola ion ( om he
La in pe cola io - il e ing), i.e. passing he ex ac an h ough he aw ma e ial; o inc ease he yield
70
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
o he inal p oduc , mul iple epea ed pe cola ion o he aw ma e ial ( epe cola ion) is used. The
mos e ec i e way o ob ain he ex ac was he me hod o ac ional mace a ion wi h ul asound,
which consis s o ex ac ing he hizomes and oo s o madde in a a io o aw ma e ial and ex ac an
(alcohol) o 1:5. The ex ac an was di ided in o 4 pa s and he aw ma e ial was successi ely in used
in each pa , he o al in usion ime was 2 days. Successi e changes o he ex ac an allowed he aw
ma e ial o be deple ed as much as possible. Then, ex ac ion was ca ied ou o 30 minu es in a wa e
ba h, 15 minu es using ul asound, and he ex ac was il e ed. This me hod showed he highes yield
o an h acene de i a i es compa ed o o he me hods o ob aining he ex ac , which was con i med
by s udying he UV spec a o he aqueous ex ac o madde aw ma e ials in an alkaline-ammonia
medium.The con en o an h acene de i a i es in he inc u e o madde ob ained by ac ional
mace a ion wi h ul asound, in e ms o ube i ic acid, was 8.7%.
