78
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
DETERMINATION OF PHYSICAL, CHEMICAL AND TECHNOLOGICAL
PROPERTIES OF THE SUBSTANCE CLOTRIMAZOLE A
Say ie a A.1
Sha ipo a S.T.2
Tashken Pha maceu ical Ins i u e, Tashken ci y, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17321129
Rele ance: Mycoses o he skin a e a common global p oblem, a ec ing 20-30% o he wo ld's
popula ion and anking second among all skin diseases. In ec ion occu s h ough con ac wi h in ec ed
people o objec s, as well as in public places such as swimming pools . The p e alence o mycoses
does no depend on geog aphy o clima e, bu on ac o s such as age, immune s a us, he p esence o
ch onic diseases, and hygiene. The incidence o diseases inc eases wi h age, especially mycoses o
he ee , which can be ound in e e y second pa ien o e 70 yea s o age. The aim o he s udy was
o de e mine he physicochemical and echnological p ope ies o he subs ance clo imazole A.
Clo imazole C22H17ClN2 whi e o whi e wi h a yellowish in c ys alline powde . Soluble in alcohol
96%, sligh ly soluble in e he , p ac ically insoluble in wa e . Clo imazole is a b oad-spec um
an i ungal agen o opical use. I s an i ungal e ec is due o he dis up ion o e gos e ol syn hesis, a
componen o ungal cell memb anes. This al e s memb ane pe meabili y and causes subsequen cell
lysis. I is e ec i e agains de ma ophy es , yeas s, and molds, as well as he causa i e agen o
pi y iasis e sicolo . e sicolo and he causa i e agen o e y h asma . I has an imic obial ac i i y
agains g am-posi i e and g am-nega i e bac e ia. Sie e analysis is he de e mina ion o he pa icle
size dis ibu ion o pa icle size dis ibu ion o powde s and g anules by sie ing hem h ough sie es.
Sie e analysis is pe o med by sie ing ma e ial samples h ough a se o s anda d sie es wi h
successi ely smalle openings om op o bo om, sepa a ing he ma e ial in o ac ions. De e mining
he pa icle size dis ibu ion o powde s and g anules is used in pha maceu ical manu ac u ing a
a ious s ages o p oduc ion. Mechanical sie ing is mos sui able when he majo i y o pa icles a e
la ge han 75 µm. The ligh weigh o smalle pa icles esul s in insu icien o ce o o e come he
su ace o ces o cohesion and adhesion du ing sie ing, causing pa icles o s ick o each o he and o
he sie e, esul ing in he e en ion o pa icles ha should o he wise ha e passed h ough he sie e.
Fo such subs ances, ai -je o ul asonic sie ing may be mo e sui able. Sie ing may be used o some
powde s o g anules wi h a median pa icle size o less han 75 µm i he me hod can be alida ed .
Flowabili y is he abili y o pa icles o solid powde ed subs ances o ma e ials o low unde he
in luence o hei own g a i y. Fo he pu poses o his Gene al Pha macopoeia Monog aph,
powde ed subs ances o ma e ials include pha maceu ical subs ances, excipien s, hei mix u es,
in e media es, and o he solid bulk ma e ials ha can be used in he p oduc ion o medicinal p oduc s.
The widesp ead use o powde s in he pha maceu ical indus y o c ea e a wide a ie y o dosage
o ms o d ugs equi es a comp ehensi e assessmen o hei echnological p ope ies, including an
e alua ion o hei lowabili y cha ac e is ics. E o s o es ablish he ela ionship be ween a ious
powde lowabili y c i e ia and he echnological p ocess o medicinal p oduc p oduc ion ha e led
o he de elopmen o a la ge numbe o es me hods o de e mining he mul i ace ed echnological
cha ac e is ics o powde s, such as lowabili y, densi y, comp essibili y , po osi y, and we abili y .
Hyg oscopici y is he p ope y o some subs ances o abso b wa e apo (mois u e) om he ai .
Hyg oscopici y is cha ac e is ic o we able hyd ophilic subs ances wi h a capilla y-po ous s uc u e
79
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
and subs ances ha a e highly soluble in wa e , especially compounds ha o m c ys al hyd a es wi h
wa e .
