90
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
MODERN METHODS OF MICROENCAPSULATING ACTIVE PHARMACEUTICAL
SUBSTANCES
Baymu a o a Zh. A.
Sou h Kazakhs an Resea ch Uni e si y named a e . M. Auezo a, Shymken , Republic o
Kazakhs an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17321945
Rele ance: Mic oencapsula ion is one o he mos p omising me hods o imp o ing he
s abili y, bioa ailabili y, and con olled elease o d ugs. De elopmen o his app oach will enable
he de elopmen o new o ms o d ug deli e y wi h ewe side e ec s.
Objec i e: To s udy mode n me hods o mic oencapsula ion o ac i e pha maceu ical
ing edien s and e alua e hei e ec i eness o he de elopmen o inno a i e dosage o ms.
Resea ch me hods: Analysis o li e a u e on mode n mic oencapsula ion echnologies.
Compa a i e s udy o coace a ion, sp ay d ying, and ex usion me hods. Use o elec on mic oscopy
o s udy mic ocapsule mo phology. Physicochemical analysis o assess he s abili y and homogenei y
o ac i e ing edien dis ibu ion. Use o ma hema ical modeling o p edic d ug sepa a ion kine ics.
Resul s: The coace a ion me hod. was ound o p oduce mic ocapsules wi h a high deg ee
o encapsula ion and con olled elease o he ac i e ing edien . Sp ay d ying ensu es p ocess
scalabili y and is sui able o hea -s able compounds. Ex usion echnology demons a ed good esul s
in he p oduc ion o long-ac ing mic og anules. Elec on mic oscopy con i med uni o m dis ibu ion
o he ac i e ing edien wi hin he capsules. Physicochemical analysis e ealed inc eased s abili y o
encapsula ed compounds compa ed o unencapsula ed o ms. Ma hema ical modeling allowed us o
p edic p oduc ion kine ics and selec op imal p ocess pa ame e s. O e all, i was ound ha mode n
mic oencapsula ion me hods signi ican ly expand he possibili ies o c ea ing inno a i e dosage
o ms.
Diag am compa es speci ied main mic oencapsula ion me hods main pa ame e s: deg ee
encapsula ion, s abili y, scalabili y And con ol ep oduc ion. 1. Coace a ion exhibi s he highes
encapsula ion e iciency and con ol, making i ideal o p oducing highe -capsule mic ocapsules.
Howe e , i s scalabili y is limi ed compa ed o o he me hods. 2. Sp ay d ying is highly scalable,
making i sui able o indus ial p oduc ion. In his case, he encapsula ion e iciency and yield con ol
a e compa able o o he me hods. 3. Ex usion occupies an in e media e posi ion: i p o ides good
s abili y and con ol o in ake, bu has a low le el o encapsula ion.
91
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
Conclusions: Thus, he choice o mic oencapsula ion me hod depends on he objec i es:
coace a ion is bes o maximum con ol and e iciency, sp ay d ying is sui able o indus ial
p oduc ion, and ex usion is op imal when i is necessa y o c ea e p olonged o ms .
