92
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
INVESTIGATION OF THE KINETIC REGULARITY OF THE FORMATION OF
INTERPOLYMER COMPLEXES OF SODIUM CARBOXYMETHYLCELLULOSE
WITH CARBOPOL AS THE BASIS FOR SOFT DRUGS
1Inagamo S.Ya.
Eshma o A.
2Baydullaye a G.E.
1Tashken Pha maceu ical Ins i u e, Tashken ci y, Republic o Uzbekis an
2Kazakh Na ional Medical Uni e si y named a e S.D.As endiya o , Alma y, Kazakhs an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17321996
Rele ance: In ecen yea s, In e polyme complexes (IPCs) based on sodium
ca boxyme hylcellulose polysaccha ide (Na-CMC) wi h a ious polyca ions ha e a oused
conside able in e es due o hei uni e sal applica ion. Cellulose-de i ed IPCs ha e g ea po en ial
in d ug pa icle deli e y sys ems in medicinal p oduc s.
The pu pose o he s udy: In his wo k, he kine ic pa e ns o he o ma ion o PKI based on
sodium ca boxyme hyl cellulose wi h a linea ca bopol ha e been s udied.
Ma e ials and me hods: Pu i ied Na-CMC, a p oduc o he Namangan Chemical Plan ,
ob ained by he e ogeneous solid-phase es e i ica ion wi h a deg ee o subs i u ion (SZ) o 70 and a
deg ee o polyme iza ion (SP) o 450, was used as he main objec o he s udy. The second
componen o IPK is ca bopol. Ca bopol a e whi e loccula hyg oscopic powde s wi h a ain odo
o ac ylic acid and is p ac ically insoluble in nonpola o ganic sol en s, swells o o m gels in wa e
and pola o ganic sol en s. The aqueous suspension o he polyme has a pH alue o 3.5 a a
concen a ion o 0.2%. The amoun o neu alizing agen can adjus he pH om 5 o 8. IR spec a in
he ange o 400-4000 cm-1 we e eco ded on NIKOLET Magna-560 IR and Speco d–75 IR
spec opho ome e s (Ka l Zeiss, GDR).
Resul s: In e polyme complexes we e ob ained by mixing aqueous solu ions o Na-CMC and
ca bopol componen s in a ious a ios o componen s and pH o he medium. IPC was s udied by
po en iome ic and iscome ic i a ion me hods. Expe imen al da a ha e es ablished ha when
polyelec oly es Na-CMC and ca bopol a e mixed, IPCs a e o med due o hyd ogen bonding. The
abo e expe imen al da a is con i med by s udying he iscosi y o IPC solu ions. The iscosi y o IPC
solu ions depends on he a io o in e ac ing componen s. The addi ion o ca bopol solu ion unde
ce ain echnological condi ions o he Na-CMC solu ion leads o an inc ease in iscosi y and eaches
a maximum alue wi h an equimola a io o in e ac ing componen s. A u he inc ease in he amoun
o ca bopol leads o a dec ease in he iscosi y o he polycomplex solu ion. The maximum change
in he iscosi y o IPC solu ions om addi i i y wi h an equimola composi ion by 15-20 Pa •s
indica es he o ma ion o a bond be ween he cons i uen componen s o IPC. These da a ha e been
con i med using IR spec oscopy me hods.
Conclusions: Thus, he in e polyme complexes based on Na-CMC and ca bopol ob ained in
mode a ely acidic egions a e s abilized due o he coope a i e hyd ogen bonding be ween he
ca boxyl g oups o Na-CMC and he ca bonyl g oups o ca bopol. I has been es ablished ha an
inc ease in he numbe o hyd ogen bonds leads o a mo e o de ed s a e o he esul ing in e polyme
complex and can be used as ca ie s o medicinal pa icles in medicinal p epa a ions.
