97
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
DISPERSIBLE TABLETS — PROSPECTS FOR THE DEVELOPMENT OF A NEW
DOSAGE FORM: CASE STUDY OF NYSTATIN DISPERSIBLE TABLET
FORMULATION
Alma o A.T.1
Buluso J.K.2
Odilo a D.M.3
S a e «Cen e o Good P ac ices», Tashken Region, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17322238
Rele ance: Dispe sible able s a e one o he mos p omising solid dosage o ms, o e ing ease
o use, especially o pa ien s wi h swallowing di icul ies such as child en, he elde ly, and pa ien s
wi h dysphagia. The abili y o ob ain a suspension om a able immedia ely be o e adminis a ion
makes his o m a ac i e o expanding he ange o o al d ugs, including an i ungal agen s like
nys a in.
Objec i e o he S udy: To de elop and op imize he o mula ion o nys a in dispe sible able s
sui able o use as a suspension in pa ien s who ha e di icul y aking solid o al o ms.
Ma e ials and Me hods: Ac i e subs ance: Nys a in Ini ial o mula ions: 10 a ian s wi h
di e en ypes o disin eg an s and ille s, as well as o he excipien s, including la o ing agen s and
swee ene s. Excipien s used: C osca mellose sodium, sodium s a ch glycola e, po idone, so bi ol,
manni ol, mic oc ys alline cellulose (MCC), s a ch, lac ose, xan han gum, and hei combina ions.
Pa ame e s e alua ed: Appea ance, weigh , ha dness, disin eg a ion ime.
Equipmen : ERWEKA ZT 320 Table and Capsule Disin eg a ion Tes e ; ERWEKA TAR 220
F iabili y Tes e ; PTK PR-LM Table P ess FRITSCH labo a o y sie es wi h sizes: 0.4 mm; 0.6 mm;
0.8 mm
Resul s: Ini ially, he impac o a ious disin eg an s was s udied; howe e , achie ing he
egula o y disin eg a ion ime (wi hin 3 minu es) was no success ul. A e shi ing ocus o he
selec ion and combina ion o ille s, sa is ac o y disin eg a ion esul s we e s ill no achie ed. None
o he es ed o mula ions p o ided s able disin eg a ion wi hin he equi ed ime ame. Va ian s wi h
c osca mellose sodium and sodium s a ch glycola e demons a ed accep able disin eg a ion imes bu
p oduced able s ha we e oo agile. The addi ion o po idone imp o ed mechanical s eng h bu
nega i ely a ec ed dispe sibili y. Fo mula ions con aining s a ch and sodium ca boxyme hyl s a ch
showed une en disin eg a ion and a endency o o m gels. Va ian s wi h mic oc ys alline cellulose
had sa is ac o y mechanical p ope ies bu poo dispe sibili y. In all cases, high sensi i i y o he
composi ion o humidi y was obse ed, which complica ed he able ing p ocess.
Conclusion: The de elopmen o an e ec i e dispe sible dosage o m o nys a in p o ed o be
mo e challenging han ini ially an icipa ed. The s udy showed ha he choice o ille s and hei
combina ions signi ican ly in luences able disin eg a ion, and none o he es ed o mula ions me
he equi ed s anda ds. Fu he esea ch is needed o iden i y sui able unc ional excipien s, possibly
in ol ing mode n supe -disin eg an s and pa icle su ace modi ica ion echnologies.
