113
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
EXTEMPORAL CHEWABLE PASTILLES: FROM THE CONCEPT OF THE
DOSAGE FORM TO QUALITY CONTROL
Inkin A.D.1
K ish ano a N. A.2
Sain -Pe e sbu g S a e Uni e si y o Chemis y and Pha macy, Sain -Pe e sbu g, Russian
Fede a ion
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17324225
Rele ance. Chewable pas illes combine as e masking, ease o use and he abili y o selec
indi idual doses, which is especially aluable in pedia ics, ge ia ics and o pa ien s wi h dysphagia.
Fo pha macies, he o m is a ac i e o i s echnological simplici y, a ailabili y o bases ( o
example, gela in) and he possibili y o apid p oduc ion o small ba ches. Howe e , me hodological
gaps emain: e minological unce ain y and di e en ia ion wi h ela ed o ms, lack o egula ed
p ocedu es o quali y con ol and s abili y in he condi ions o ex empo al p oduc ion. Compa ison
wi h he equi emen s o he Pha macopoeia and de elopmen o simpli ied, ep oducible algo i hms
and apid con ol me hods a e c i ical o sa e implemen a ion in pha macy p ac ice.
Objec i e: o s udy chewable pas illes as a dosage o m, o jus i y hei sui abili y o
ex empo al manu ac u e in a pha macy and o demons a e he simplici y o he echnological p ocess
and quali y con ol.
Tasks: 1. Cla i y he de ini ion o "chewable pas illes", indica e hei place in he nomencla u e
o dosage o ms and dis inguish hem om chewable able s, lozenges and pas illes. 2. Jus i y he
sui abili y o he mold o ex empo al p oduc ion in pha macies. 3. Sugges apid quali y con ol
me hods based on he equi emen s o he Pha macopoeia.
Ma e ials and me hods: The s udy was based on pha macopoeial a icles o he S a e
Pha macopoeia o he Russian Fede a ion and scien i ic a icles on quali y con ol o chewable
pas illes. The analysis uses he ollowing me hods: con en analysis, desc ip i e and compa a i e
analysis.
Resul s: Chewable pas illes a e a dosage o m in which he ac i e subs ance is dis ibu ed in
an elas ic‑plas ic, non- lowing base. Unlike pas illes and lozenges, his o m is designed o chewing
and is mainly ocused on achie ing a sys emic e ec . O ganolep ic de iciencies o medicines a e
e ec i ely le eled by he use o la o ings and swee ene s, which inc eases adhe ence o ea men .
The echnological p ocess is ela i ely simple and in ol es mel ing he gela in mass wi h subsequen
dosing o he mel in o silicone molds. As an exp ess me hod o quan i a i e analysis, i ime y is
sui able a e sample p epa a ion, which consis s in dissol ing he lozenge in a boiling wa e ba h
wi h subsequen cooling.
Conclusions: chewable pas illes a e a dosage o m wi h an elas ic-plas ic, non- lowing base,
in ended o chewing and mainly sys emic ac ion. The mold is echnologically a ailable o
ex empo al p oduc ion in pha macies. Simple echnological schemes (gela in mass mel - dosage in o
molds) and exp ess con ol ( i ime y a e dissolu ion in a wa e ba h) a e p oposed. Fo sa e
implemen a ion, chewable pas illes should be sepa a ed as an independen dosage o m and
accele a ed me hods should be de eloped acco ding o he equi emen s o he Pha macopoeia wi h
hei subsequen alida ion.
