137
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
DEVELOPMENT OF TECHNOLOGY AND QUALITY ASSESSMENT OF DENTAL
GEL
N.M. Rizaye a1
A. Alko o 2
Tashken Pha maceu ical Ins i u e, Tashken ci y, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17326011
Rele ance: Pa o and o al ca i y diseases a e mul i ac o ial in na u e and, as es ablished by
mode n esea ch, a e caused by mic obial agg ession. The e o e, den al p oduc s should p ima ily
ha e an an ibac e ial e ec . Conside ing he accompanying in lamma o y p ocesses, pain, and
delayed issue egene a ion, den al p epa a ions should be combined, possessing an i-in lamma o y,
analgesic, and p omo ing accele a ed issue egene a ion. The a icle is dedica ed o de eloping he
echnology o a den al gel based on mode n hyd ophilic bases, selec ing he op imal composi ion, and
choosing p ese a i es. The a icle p o ides a classi ica ion, b ie desc ip ion, and possible side
e ec s o mode n o al candidiasis medica ions.
Resea ch objec i e: Conduc esea ch on selec ing he composi ion o a me onidazole and
nys a in-con aining den al gel, selec ing he op imal basis o de eloping a gel echnology o ea ing
pe iodon al diseases.
Ma e ials and me hods: Hyd ophilic gel o me s eadily inco po a e la ge quan i ies o d ugs
and con ibu e o hei comple e and uni o m elease, allowing o he egula ion o he
biopha maceu ical and s uc u al-mechanical p ope ies o den al gels wi hin he necessa y ange.
Hyd ophilic gel- o ming agen s include aqueous solu ions o polyme s such as sodium - CMC, MC,
hyd oxye hylcellulose, ca bopol, sodium algina e, gela in, and pec in. The gel- o ming pH o he
abo e-men ioned bases lies in he neu al egion, which is con enien o o al use.
Resul s: A numbe o physicochemical indica o s we e iden i ied, including he appea ance,
homogenei y o he gel, he mal s abili y, pH alue o he solu ion ob ained by aqueous ex ac ion,
and colloidal s abili y. Visual de e mina ion o he gel's appea ance was ca ied ou as ollows: a gel
sample was applied o a slide wi h a hin laye and hen assessed wi h he naked eye. To assess he
homogenei y o he gel, ou samples weighing 0.02-0.03 g we e aken. Each sample was applied o
a slide, co e ed wi h ano he slide, and p essed igh ly o c ea e spo s abou 2 cm in diame e . As a
esul , he absence o pa icles in he s ains indica es ha he p epa ed gel mee s he equi emen s o
he ND. De e mina ion o he pH o he aqueous ex ac o he gel was ca ied ou by he
po en iome ic me hod using he Me le Toledo (Ge many) pH me e . Du ing he measu emen
p ocess, 5.0 g ams o gel we e mixed wi h 50 millili e s o pu i ied wa e and hea ed in a wa e ba h
a 50-60°C, a e which hey we e il e ed h ough a il e wi h whi e ape (TU 6-09-1678-86). The
da a ob ained du ing he expe imen a e p esen ed in he able. De e mina ion o colloidal s abili y.
App oxima ely 3.0-5.0 g o he gel sample was weighed and cen i uged in a CUM cen i uge a 1500
pm o 5 minu es. Gel sepa a ion was no obse ed. To de e mine he he mal s abili y, 5 es ubes
we e aken and illed o 2/3 and placed in a he mos a a a empe a u e o 40-45°C o 24 hou s, hen
he samples we e placed in a e ige a o o 24 hou s a 10-12°C. A e 24 hou s, hey we e kep a
oom empe a u e. When iewed wi h he naked eye, no laye ing o he gel samples was obse ed.
Conclusions: The ob ained esul s show ha he main ad an age o he new sys em - a gel
abso bed in he o al mucosa - is he ease o use, he possibili y o long- e m ac ion, which allows o
a cou se o ea men in he ea men o pe iodon al diseases.The quali y indica o s o he gel we e
138
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
de e mined: desc ip ion, homogenei y o consis ency, solubili y, pH o aqueous solu ion, colloidal
s abili y, and he mos abili y.
