139
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
STUDY OF TECHNOLOGICAL PROPERTIES OF TABLET MASS
“PODAGRIN”
E naza o A.M.1
Yunuso a H.M.2
Tashken Pha maceu ical Ins i u e, Tashken ci y, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17326087
Rele ance: The basis o he de elopmen o gou is hype u icemia, which is a cons an excess
o u ic acid in he blood. Gou is p ima y and seconda y. P ima y gou is caused by a he edi a y
mal o ma ion o enzymes in ol ed in he syn hesis o u ic acid and a iola ion o he mechanism o
exc e ion o u ic acid by he kidneys. De iciency o he guanidine phospho ibosyl ans e ase enzyme
leads no only o hype u icemia and gou . Seconda y gou occu s as a complica ion o p e ious
diseases and pa hological p ocesses, as well as as a esul o aking medica ions. De elopmen o d ug
o ms om subs ances exhibi ing bioac i e p ope ies wi h di e en e ec s, de elopmen o d ugs
wi h high e iciency o hei mechanism o ac ion based on syne gism is one o he u gen asks o
oday.
Aim o he s udy: o s udy he echnological p ope ies o able mass con aining bioac i e
subs ances and excipien s. To de elop highly e ec i e d ugs based on s ong syne gism.
Ma e ials and me hods: he pa ame e s such as he composi ion o he able mass ob ained om
he echnological p ocesses, dispe sibili y, dispe sion densi y, ee- all angle and esidual mois u e
we e s udied. Scien i ic esea ch was conduc ed on he physicochemical and echnological p ocesses
o he able mass using he me hods gi en in egula o y documen s and gene ally accep ed me hods.
Resul s: In he p epa a ion o able mass om he expe imen ally ob ained subs ances, se e al
able masses we e p epa ed using he ollowing excipien s. In he p epa a ion o able mass,
scien i ic esea ch was conduc ed on able masses ob ained by di ec p essing me hod based on
ille s, emulsi ying agen s, binde s, and lub ican s. Scien i ic esea ch is being conduc ed on he
cha ac e is ics o he esul ing able masses such as g ain composi ion, bulk densi y, dispe sibili y,
esidual mois u e, and echnological p ocess p ope ies. Technological p ope ies o able masses
ob ained by di ec p essing me hod. The so ing composi ion is -2000 +1000 μm sie e, 3.80-4.52%
in -1000 +500 μm sie es, 20.12-20.08% in -500+250 μm sie e se , 48.18 -47.65 -32.78% in -160 μm
sie e se , 4.10 - 3.24 - 2.6% in la ge-sized sie es, ela i ely low pe cen age in small sie es and hey
di e g ea ly om each o he .
Mo e han 10 able masses we e p epa ed using bioac i e subs ances diclo enac sodium,
sodium bica bona e and ci ic acids, p ese a i es, and ille s, binde s and lub ican s, excipien s. The
echnological p ope ies o able masses we e s udied and scien i ic esea ch was conduc ed. The
esul s ob ained a e as ollows. Dispe sion 0.95 - 4.32 -7.87 *10-3 kg/s, densi y 325.10 - 314.20 -
489.25 kg/m3, angle o ee all 65.95 - 64.75 - 63.70 deg ees, comp essibili y 50.45 - 85.58 -83.25
N, esidual mois u e Such indica o s we e 4.35-3.60-6.75%, i was s udied on he basis o scien i ic
esea ch.
Conclusion: he echnological p ope ies o he able mass ob ained by he di ec p essing
me hod acco ding o he selec ed me hods did no show hei posi i e cha ac e is ics. Based on he
esul s o he esea ch, in o de o imp o e he echnological p ope ies o he ob ained able masses,
i is app op ia e o use binding aids.
