155
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
SELECTION OF THE OPTIMAL TYPE OF EXTRACTANT FOR OBTAINING
EXTRACT FROM COMMON CORN (ZEA MAYS L.) RAW MATERIAL
K.M.Nazi o a
R.К.Sadiko a
Tashken Pha maceu ical Ins i u e
e-mail: [email p o ec ed], el: +998909093808
h ps://doi.o g/10.5281/zenodo.17328595
Rele ance: Co n silk (Zea mays L.) is a sou ce o biologically ac i e subs ances (BAS), among
which la onoids a e o pa icula impo ance. They ha e diu e ic, an i-in lamma o y, and chole e ic
e ec s, which de e mines hei pha macological alue. The e ec i eness o ob aining s anda dized
he bal p epa a ions la gely depends on he co ec selec ion o an ex ac an ha ensu es he
maximum yield o ac i e subs ances. In his ega d, i is ele an o s udy he ex ac ion condi ions
ha a ec he ex ac ion o la onoids.
Objec i e: To selec he ype o ex ac an o ob aining an ex ac om he s igmas o Zea
mays wi h he highes yield o la onoids.
Ma e ials and me hods: D ied co n silk ha me he equi emen s o he S a e Pha macopoeia
o he Republic o Uzbekis an was used as aw ma e ial. Ex ac ion was ca ied ou by mace a ion a
a aw ma e ial-ex ac an a io o 1:10. Mace a ion is a me hod o in using plan aw ma e ials in an
ex ac an a oom empe a u e wi h pe iodic s i ing, which ensu es g adual and uni o m ex ac ion
o ac i e subs ances. Wa e and alcohol solu ions o a ious concen a ions (40%, 50%, 60%, 70%,
80%, and 90%) we e used as ex ac an s. The quan i a i e de e mina ion o he o al la onoids was
ca ied ou by spec opho ome ic me hod in e ms o lu eolin-7-glycoside.
Resul s: The analysis e ealed ha he concen a ion o he ex ac an has a signi ican e ec
on he yield o la onoids. The highes peak alue was eco ded when using 60% e hanol.
Table 1
Resul s o spec opho ome ic analysis o Zea mays L. ex ac s using a ious ex ac an s
Ex ac an
Peak alue, mg/ml
Wa e
0,095
40% e hanol
0,109
50% e hanol
0,036
60% e hanol
0,285
70% e hanol
0,176
80% e hanol
0,269
90% e hanol
0,119
In a 60% alcohol ex ac o co n silk, he quan i a i e con en o la onoids was de e mined by
spec opho ome y in e ms o lu eolin-7-glycoside, amoun ing o 0.465%, which exceeds he no m
o 0.35%.
Conclusions: The op imal ex ac an o ob aining a d y ex ac o co n silk by mace a ion is
60% e hanol, which ensu es maximum la onoid ex ac ion. This app oach allows ob aining a
s anda dized ex ac wi h high biological ac i i y, which opens up p ospec s o i s u he use in he
de elopmen o dosage o ms.
