279
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
ASSESSMENT OF MICROBIOLOGICAL PURITY OF CLARY SAGE LEAVES
(SALVIA SACLAREA L.)
Eshnaza o a N.H.
Pula o a D.K.
U mano a F.F.
Tashken Pha maceu ical Ins i u e, Tashken ci y, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17334353
Rele ance: Sal ia L. (sage) is one o he la ges gene a o he Lamiaceae amily. Plan s o his
genus ha e long been used in olk and adi ional medicine in a ious coun ies o elie e pain, p o ec
agains oxida i e s ess, ee adical damage, angiogenesis, in lamma ion, as well as bac e ial and
i al in ec ions. They a e g own due o hei a oma ic p ope ies o he p oduc ion o ood addi i es
and essen ial oils, pha maceu icals, dyes, cosme ics and biocides. The subs ances isola ed om hem
a e cha ac e ized by signi ican cy o oxic, an i–in lamma o y, an imic obial, an i i al,
an iplasmodial, an ipla ele agg ega ion, g ow h-inhibi ing and epellen ac i i y. One o he po en ial
sou ces o biologically ac i e subs ances wi h aluable pha macological p ope ies is he objec o
ou esea ch, cla y sage (Sal ia sacla ea L.).
The pu pose o he s udy. Taking in o accoun ha he bal medicines ha a e no s e ilized
du ing he manu ac u ing p ocess can be con amina ed wi h mic oo ganisms, we ha e s udied he
mic obiological equency o a new medicinal plan o he domes ic lo a, cla y sage, in o de o
in oduce i in o medical p ac ice.
Ma e ials and me hods. The objec o he s udy was he lea es o cla y sage ha es ed du ing
he lowe ing pe iod om bo anically eliable plan s in he illage o Chimgan, Tashken egion. The
es s we e ca ied ou unde asep ic condi ions in acco dance wi h he ins uc ions o he S a e
Pha macopoeia o Uzbekis an. I included quan i a i e de e mina ion o iable bac e ia and ungi, as
well as iden i ica ion o mic oo ganisms, he p esence o which is unaccep able in non-s e ile
medicines.
Resul s. Table 1 summa izes he esul s o a s udy o he mic obiological pu i y o cla y sage
lea es.
Таблица 1
№
Indica o s
HD
Requi emen s
Analysis
esul s
HD compliance
1.
To al numbe o ae obic bac e ia
(in 1 g o he p epa a ion)
No mo e han
105
220 КОЕ
Respond
2.
To al numbe o yeas and mold
ungi (pe 1 g o p epa a ion)
No mo e han
104
80 КОЕ
Respond
3.
G oup o En obac e iaceae
(Esche ichia coli and
Salmonella), Pseudomonas
ae oginosa and S aphylococcus
au eus
Mus be missing
Missing
Respond
I ollows om he abo e da a ha he lea es o cla y sage ully comply wi h he equi emen s
o he mic obiological pu i y o plan aw ma e ials.
280
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
Conclusions. S udies ha e been conduc ed o assess he mic obiological pu i y o aw
ma e ials o cla y sage lea es. The da a ob ained will be in demand when de eloping app op ia e
egula o y documen a ion o i .
