316
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
DEVELOPMENT AND STANDARDIZATION OF SYNBIOTICS WITH
LACTOBACTERIUM PLANTARUM SUBSTANCE AND OLIGOSACCHARIDES
Kalmakhano a L.M.
Dzhumagaziye a A.B.
Kazakh Na ional Medical Uni e si y named a e S.D. As endiya o , Alma y ci y, Republic o
Kazakhs an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17335439
Rele ance: Acco ding o he de ini ion by he Wo ld Heal h O ganiza ion (WHO), p obio ics
a e iable mic oo ganisms ha , when adminis e ed in adequa e amoun s, con e a heal h bene i on
he hos . In 2013, he In e na ional Scien i ic Associa ion o P obio ics and P ebio ics e ined his
de ini ion, s a ing ha he e m «p obio ic» may only be applied o p epa a ions ha mee he
ollowing equi emen s: accu a e in o ma ion on he mic oo ganisms p esen , including hei s ains,
is p o ided; a su icien numbe o iable bac e ia is main ained un il he end o he shel li e; and
s udies con i ming he sa e y and e icacy o he in oduced s ains a e a ailable. Thus, e men ed
ood p oduc s and ecal ansplan s ha do no speci y species and s ain composi ion a e no
conside ed p obio ics. Expe imen al s udies and nume ous clinical obse a ions ha e shown ha
di e en p obio ic s ains a e necessa y o he co ec ion o in es inal symp oms.
Objec i e o he s udy: De elopmen o echnology and s anda diza ion o synbio ics wi h
Lac obac e ium plan a um subs ance and oligosaccha ides.
Ma e ials and me hods: Labo a o y me hods we e used o op imize he e men a ion
condi ions o Lac obac e ium plan a um wi h a ious oligosaccha ides, including inulin and
uc ooligosaccha ides. Me hods included cul i a ion pa ame e s, iden i ica ion o c i ical s eps in
biomass ex ac ion, and de e mina ion o con ol poin s.
Resul s: Op imal e men a ion condi ions ensu ed high iabili y o Lac obac e ium plan a um
when combined wi h di e en oligosaccha ides. Quali y s anda ds we e also de eloped o he
ob ained synbio ics, including me hods o con olling iable cell coun s and oligosaccha ide ac i i y.
Conclusion: The s udy success ully de eloped a echnology o p oducing synbio ics based on
Lac obac e ium plan a um and oligosaccha ides, as well as es ablished quali y s anda ds. The esul s
open new pe spec i es o he de elopmen o unc ional ood p oduc s ha con ibu e o human
heal h imp o emen .
