383
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
SYNTHESIS, STRUCTURE, AND INVESTIGATION OF A COMPLEX COMPOUND
BASED ON THE BENZIMIDAZOLE DERIVATIVE OF Co (II)
Khujae a F.A.1,2
Allamu odo a SH.G.2
Damino a SH.SH.2
1Tashken Pha maceu ical Ins i u e, Tashken , Republic o Uzbekis an
2Na ional Uni e si y o Uzbekis an, Tashken , Republic o Uzbekis an
[email p o ec ed]. el:(90) 939-63-16
h ps://doi.o g/10.5281/zenodo.17339240
Rele ance: Cu en ly, benzimidazole and i s de i a i es a e he main aw ma e ials o he
de elopmen o impo an he apeu ic agen s in medicine and pha maceu icals. Fo example,
benzimidazole and i s de i a i es exhibi pha macological ac i i ies such as an imic obial, an i i al,
an icance , an i-in lamma o y, and neu o opic, psychoac i e, and analgesic p ope ies. The syn hesis
o d ugs wi h high pha maceu ical p ope ies and he c ea ion o new gene a ions o d ugs using new
benzimidazole de i a i es is cu en ly one o he mos impo an a eas o he mode n pha maceu ical
indus y.
Pu pose o he s udy: Syn hesis o a new coo dina ion compound in ol ing cobal (II) and
1H-benzimidazole-2-ca boxylic acid (1H-BIZ).
Ma e ials and me hods: Di e en ial he mal analysis (DTA) was used o de e mine he
he mal s abili y and composi ion o he esul ing complex compound.
Resul s: To syn hesize he complex compound, he masses o me al and ligand we e aken in a
1:2 a io. A 96 pe cen solu ion o e hanol was used as he sol en . The mix u e was s i ed egula ly
o 3-4 hou s and s o ed in a da k place o d y. A e a week, blue c ys als o med.
Analysis o he dynamic he mog a ime ic analysis (DTGA) cu e o he complex
[Co(C8H5N2O2)2(C7H6N2)2] shows ha he DTGA cu e mainly occu s be ween 3 in ense
decomposi ion empe a u es. The 1s decomposi ion s ep occu ed in he empe a u e ange o 125-
250°C, wi h a mass loss o 0.266 mg (4.46%). In his case, he decomposi ion o he wa e o
c ys alliza ion con ained in he complex compound was obse ed. The main decomposi ion occu ed
in he 2nd ange a 250-330°C (s ong exo he mic peak in DSC), wi h he la ges mass loss o 1.524
mg (25.75%). In addi ion, decomposi ion in small anges co esponds o empe a u es o 330-550°C,
wi h a mass loss o 13.2%. The hi d decomposi ion ange includes 550-680°C, and he mass loss in
his ange is 14.2%. De a og aphic s udies show ha he main mass loss occu s in he ange o 125-
680 °C, wi h 99% o he main mass being los . A he end o he analysis, he esidual mass consis s
o CoO and o he ino ganic decomposi ion p oduc s, accoun ing o 12.96% o he o al mass.
384
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
Conclusions: The he mal s abili y o he syn hesized complex was de e mined by
he mog a ime y. Endo- and exo-e ec s we e disco e ed and he mal des uc ion p oduc s we e
iden i ied, and i was shown ha he he mal decomposi ion o complexes p oceeds in se e al s ages,
including combus ion o he o ganic pa o he molecule, decomposi ion o he sal , oxida ion o he
decomposi ion p oduc s, and he o ma ion o a me al oxide.
