386
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
STUDY OF BIOLOGICALLY ACTIVE COMPONENTS OF PEROVSKIA
BOTSCHANTZEVII
Mullabae a S.Kh.
Egamo a F.R.
Negma o a M.U.
Siddiko D.R.
Bo i o E.Kh.
Ins i u e o Plan Chemis y named a e academician S.Yu. Yunuso , AS RUz, Tashken
e-mail: [email p o ec ed], phone (99)724-29-64
h ps://doi.o g/10.5281/zenodo.17339296
Rele ance: The g owing need o medicinal p oduc s p epa ed on he basis o plan aw
ma e ials is explained by hei high con en o biologically ac i e compounds, good e iciency, sa e y,
and a wide ange o he apeu ic ac ion. Pe o skia bo schan ze ii Ko ale sk. & Koczk ( amily
Lamiacaeae) is a medicinal, essen ial oil, dye and honey plan g owing on ocky slopes, pebbles, in
he i e alleys o Ky gyzs an, Uzbekis an, Tajikis an, and A ghanis an.
Pu pose o he s udy. Isola ion and s udy o biologically ac i e componen s o he oo s o
Pe o skia bo schan ze ii collec ed in he Fo ish dis ic o he Jizzakh egion.
Ma e ials and me hods. The c ushed ai -d ied plan ma e ial was ex ac ed i e imes a oom
empe a u e wi h me hanol. The combined ex ac was e apo a ed in a acuum, he esidue was mixed
wi h silica gel, d ied and ch oma og aphed on a silica gel column, washing successi ely wi h
gasoline, chlo o o m, e hyl ace a e and a mix u e o e hyl ace a e-me hanol (8:2).
Resul s. Ch oma og aphy o he ac ions ob ained e ealed se en indi idual na u al
compounds. Based on he s udy o UV, 1H and 13C NMR spec a, he isola ed subs ances we e
iden i ied wi h he di e penoids osmadial (1) and sujiol (2), bis-no -di e penoids p zhe alskin (3)
and nimbiol (4), no -di epenoids c yp o anshinone (5) and anshinone IIA (6), and also he es e o
ca eic acid - nepe oidin B (7). The spa ial s uc u e o osmadial and nimbiol was con i med by X-
ay s uc u al analysis (XRD).
The an i-in lamma o y ac i i y o c yp o anshinone has been s udied in he Ins i u e's
Pha macology and Toxicology Depa men . I has been shown ha c yp o anshinone exhibi s a
p onounced an i-in lamma o y e ec in he expe imen , supp essing bo h he exuda i e and
p oli e a i e phases o in lamma ion. The an i-exuda i e e ec o c yp o anshinone has also been
e ealed in he de elopmen o expe imen al se osi is. Unde he in luence o c yp o anshinone,
exuda ion in o he pleu al and abdominal ca i y dec eases in esponse o in ape i oneal
adminis a ion o sil e ni a e. Mul iple adminis a ion o he es agen o a s wi h co on balls
implan ed unde he skin o he back inhibi ed he o ma ion o g anula ion- ib ous issue a ound
hem. In e ms o he se e i y o i s e ec , c yp o anshinone in he expe imen s conduc ed showed
ce ain ad an ages o e diclo enac.
Conclusions. I has been shown ha he oo s o Pe o skia bo schan ze ii a e a ich sou ce o
biologically ac i e compounds and can be used o c ea e e ec i e medicines and die a y supplemen s.
