Supplemen a y Figu es
Figu e S1. P opo ion o poin mu a ions de ec ed in he homozygous s a e. Gi en he
ull-sibling ma ing design o ou MA expe imen , we expec many new mu a ions o become
homozygous by he ime o genome sequencing, ollowing 30 bo leneck gene a ions, bu
he e ozygous mu a ions will s ill be p esen ha ha e no ye become ixed.
Figu e S2. Median co e age by ch omosome a m o MA line 11. In his line, he ele a ed
median co e age on ch omosome 4 (1.38- imes he genome-wide median) likely indica es
isomy.
