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RELATIONSHIP BETWEEN TESTOSTERONE LEVELS AND METABOLIC
DISORDERS IN MEN WITH TYPE 2 DIABETES MELLITUS
O iqo O abek Bax iyo jon o`g`li
Mas e ’s S uden , Andijan S a e Medical Ins i u e.
h ps://doi.o g/10.5281/zenodo.17670139
Abs ac . And ogen de iciency is a common como bidi y in men wi h ype 2 diabe es
melli us (T2DM) and in luences me abolic p ocesses and disease p og ession. The aim o his
s udy was o e alua e he clinical and me abolic cha ac e is ics o men wi h T2DM depending on
hei es os e one le els. Fo y pa ien s we e examined and di ided in o g oups wi h no mal and
educed es os e one le els. I was ound ha lowe es os e one le els a e associa ed wi h highe
body mass index (BMI), inc eased HOMA-IR alues, and p onounced lipid me abolism
dis u bances. Nega i e co ela ions we e obse ed be ween es os e one le els, insulin esis ance,
and iglyce ides. These indings highligh he need o ea ly diagnosis o and ogen de iciency o
imp o e p ognosis and co ec me abolic diso de s in men wi h T2DM.
Keywo ds: Tes os e one; Type 2 diabe es melli us; Insulin esis ance; HOMA-IR;
Dyslipidemia; Me abolic synd ome; Men’s heal h; Endoc inology.
In oduc ion. The incidence o and ogen de iciency in men wi h ype 2 diabe es melli us
(T2DM) is inc easingly ecognized as an impo an ac o in luencing me abolic homeos asis.
Reduced es os e one le els a e associa ed wi h insulin esis ance, isce al obesi y, impai ed lipid
me abolism and a highe ca diome abolic isk [1, 2]. The p esen s udy aimed o e alua e he
me abolic and biochemical cha ac e is ics o men wi h T2DM depending on hei es os e one
le els. Unde s anding his ela ionship may con ibu e o he imp o emen o diagnos ic
algo i hms and indi idualized he apeu ic app oaches in endoc inology [3].
Ma e ials and me hods. A o al o 40 men aged 40–65 yea s wi h con i med T2DM we e
examined. All pa icipan s we e di ided in o wo g oups acco ding o se um o al es os e one
le els:
1. No mal es os e one (n = 18),
2. Low es os e one (n = 22; <12 nmol/L).
An h opome ic measu emen s (body mass index, wais ci cum e ence) and as ing blood
samples we e ob ained o de e mine glucose, insulin, HOMA-IR index, o al choles e ol, HDL-
choles e ol, and iglyce ides. Se um es os e one was measu ed using immunoassay me hods.
S a is ical analysis included mean ± s anda d de ia ion, in e g oup compa ison, and
Pea son co ela ion analysis o e alua e associa ions be ween es os e one le els and me abolic
pa ame e s. A p- alue <0.05 was conside ed s a is ically signi ican .
Resul s. A dec eased es os e one le el was iden i ied in 55% o he examined men.
Pa icipan s wi h low es os e one demons a ed signi ican ly highe alues o BMI, as ing
glucose, as ing insulin, and HOMA-IR index compa ed wi h men wi h no mal and ogen s a us.
Lipid abno mali ies we e also mo e p onounced in he low- es os e one g oup, pa icula ly
mani es ed by dec eased HDL-choles e ol and ele a ed iglyce ides.
Co ela ion analysis showed a mode a e nega i e ela ionship be ween se um o al
es os e one and HOMA-IR ( = –0.48; p < 0.05), indica ing ha a educ ion in es os e one is
2025
NOVEMBER
NEW RENAISSANCE
INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE
VOLUME 2 | ISSUE 11
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associa ed wi h inc eased insulin esis ance. Addi ionally, es os e one le els nega i ely co ela ed
wi h iglyce ides ( = –0.41; p < 0.05), sugges ing he con ibu ion o and ogen de iciency o
dyslipidemia in pa ien s wi h T2DM.
O e all, he indings demons a e ha me abolic al e a ions in men wi h T2DM a e mo e
se e e when es os e one le els a e educed. These esul s highligh he in e play be ween
ho monal imbalance and me abolic dys unc ion and poin o he need o a comp ehensi e
e alua ion o and ogen s a us in he managemen o diabe ic pa ien s [4].
Conclusion. Low es os e one le els in men wi h ype 2 diabe es melli us a e associa ed
wi h a mo e ad e se me abolic p o ile, including inc eased insulin esis ance and mo e
p onounced lipid dis u bances. Sc eening o and ogen de iciency may se e as an impo an
componen o isk assessmen and help op imize ea men s a egies aimed a imp o ing
me abolic con ol and educing ca dio ascula isk in his pa ien popula ion.
Re e ences
1. Cai L., Zeng P., Liao M. Associa ion o o al es os e one wi h insulin esis ance and
me abolic pa ame e s in men wi h ype 2 diabe es: a c oss-sec ional s udy. Diabe es
Resea ch and Clinical P ac ice. 2024;210:110245.
2. Kal a S., Kapoo D. Tes os e one and ca diome abolic heal h in men wi h diabe es: an
upda ed clinical e iew. Wo ld Jou nal o Diabe es. 2024;15(2):123–134.
3. Jia X., Chen Y., He S. Rela ionship be ween se um es os e one le els and an h opome ic
and me abolic ac o s in adul males: a popula ion-based analysis. F on ie s in
Endoc inology. 2023;14:1178213.
4. Nguyen C.P., Chen R., Hu Y. P e alence and me abolic impac o male hypogonadism in
ype 2 diabe es: a sys ema ic e iew and me a-analysis. Jou nal o Clinical Endoc inology
& Me abolism. 2023;108(5):1341–1352.
