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RESULTS OF MAMMOGRAPHIC SCREENING FOR
INTRADUCTAL BREAST FORMATIONS
F.M. Djalolo a
Depa men o Oncology, Andijan S a e Medical Ins i u e
h ps://doi.o g/10.5281/zenodo.17674596
Abs ac . In aduc al ca cinoma, o duc al ca cinoma in si u (DCIS), is he p ein asi e
o m o b eas ca cinoma. In mos ins ances, i is clinically inappa en and is disco e ed
inciden ally du ing his ologic examina ion o b eas issue iden i ied as abno mal by
mammog aphy.
Keywo ds: duc al ca cinoma in si u (DCIS), b eas ca cinoma, clinic and sc eening
mammog aphic s udie, calci ica ions.
In oduc ion
Cu en ly, one o he mos p essing p oblems no only in oncology bu also in heal hca e
in gene al is he p e en ion o b eas cance (BC), which is due o he apid, s eady and widesp ead
g ow h in he incidence o his o m o cance , which has aken i s place in he s uc u e o
mo bidi y in women wi h malignan neoplasms (Bluekens AM e all 2012). This is due o he
leading posi ion o his umo in women, ou pacing o he malignan neoplasms in equency o
occu ence (B ay F e all 2018). Despi e a la ge numbe o s udies de o ed o imp o ing he
me hods o diagnosis and ea men o BC, he esul s a e a om always sa is ac o y.
Mammog aphic sc eening has educed b eas cance - ela ed mo ali y by 30% (Taglia ico
AS e all, 2016). Howe e , he sensi i i y o mammog aphy is abou 70%, especially in women
wi h dense b eas issue (Pisano ED e all, 2005). Cu en ecommenda ions o he Socie y o
B eas Imaging, he Ame ican College o Radiology, and he Na ional Comp ehensi e Cance
Ne wo k equi e annual mammog aphic sc eening, s a ing a age 40 and olde in cases o a e age
oncological isk. Fo women wi h a high isk o b eas cance (mo e han 20% du ing li e), MRI
is ecommended in addi ion o mammog aphy (Riedl CC e all, 2015).
Fo women wi h a BRCA1/2 gene mu a ion, wi h TP53 Li F aumeni synd ome, o who
ecei ed adia ion he apy o he ches a ea be o e age 30, annual mammog aphy and, possibly,
MRI a e ecommended om he momen o iden i ica ion. In he USA, women wi h dense b eas
issue a e wa ned abou he ad isabili y o addi ional sc eening (mammog aphy + ul asound /
MRI) (Taglia ico AS e all, 2016). I calci ica ion is de ec ed du ing sc eening mammog aphy,
image magni ica ion is ecommended o de e mine he ex en o he lesion. I calci ica ion is
associa ed wi h s uc u al asymme y o he mamma y gland o he p esence o a mass, addi ional
examina ion using ul asound is equi ed o diagnose in asion.
To imp o e he p ima y sc eening o DCIS, i is ecommended o conduc s udies
compa ing he diagnos ic e iciency o ul asound and adiological me hods o popula ion
sc eening. The e is insu icien li e a u e da a on such a compa ison oday, which does no allow
de eloping a single e ec i e and adequa e s a egy o he p e en i e diagnosis o b eas umo s.
MATERIALS AND METHODS OF RESEARCH
As women, a o al o 144 pa ien s, 77 o hem had pain in he mamma y glands o a ious
ages, o he pe iod om 2017 o 2022, we e included, palpa ion o he mamma y gland de i a i e,
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and pa hological discha ge om he nipple wi hou he p esence o hype p olac inemia. 67 women
aged 40 and olde , mammog aphy e ealed mamma y masses, and no subjec i e symp oms
indica i e o mamma y gland pa hology we e included. The me hods o clinic and sc eening
mammog aphic s udies.
RESULTS
Du ing mammog aphic sc eening in women who we e subsequen ly diagnosed wi h an
in aduc al o ma ion, in 120 cases ou o 144, a ocal shadow was ound ha was suspicious o
he o ma ion o b eas cance . Thus, he sensi i i y o s anda d mammog aphy o in aduc al
o ma ion was 83.33%, which is signi ican ly highe han he sensi i i y o clinical sc eening
(X2=29.72, p<0.001). Mo eo e , he sensi i i y o mammog aphy was compa able bo h among
he glands wi h a malignan neoplasm and wi h a benign one (80.77% and 83.90%, espec i ely,
chi squa e=0.15, nd). Since he c i e ion o inclusion in he s a is ical analysis o he s udy was
he p esence o a e i ied in aduc al o ma ion, he speci ici y o he me hod was no e alua ed.
Compa ison o he esul s o de ec ion o in aduc al neoplasms on he basis o mammog aphy and
on he basis o clinical signs e ealed a signi ican weak ela ionship be ween hese diagnos ic
app oaches: he co ela ion coe icien was +0.42 o all cases (p<0.01), +0.39 o malignan
neoplasms (p<0.05) and +0.42 o benign neoplasms ( p<0.01).
Among all cases o in aduc al o ma ions diagnosed in he cou se o his s udy, only 37%
o cases showed he p esence o clinical symp oms o he o ma ion and mammog aphic signs. In
46% o cases, sc eening mammog aphy e ealed he o ma ion agains he backg ound o a "silen "
clinical cou se, which accoun ed o 55.83% o all mammog aphically "posi i e" cases. In 17% o
cases, pa ien s showed clinical signs o cance wi hou mammog aphic con i ma ion, which
accoun ed o 31.17% o all clinically "posi i e" cases (Fig.1).
Fig-1 The equency o occu ence o mammog aphically and clinically "posi i e" and
"nega i e" cases o in aduc al o ma ions/
The equency o occu ence o mammog aphically and clinically "posi i e" cases o
in aduc al o ma ions in he g oups wi h malignan and benign pa hology did no di e (Table-1).
Table 1.
67; 46%
24; 17%
53; 37%
mammog aphically+
clinically+
mammog aphically+/clini
cally+
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F equency o occu ence o mammog aphically and clinically "posi i e" in aduc al b eas
o ma ions, depending on he p esence o malignancy ( ela i e pe cen age in he g oup is shown
in pa en heses)
Calcina es a e one o he impo an mammog aphic indings associa ed wi h in aduc al
o ma ions. This phenomenon was ound on 77 mammog aphic images (53.47% o all
mammog ams pe o med), while he p esence o calci ica ions was mo e cha ac e is ic o
malignancies (19 cases ou o 26) compa ed o benign pa hologies (58 cases ou o 118): 73.08%
and 49.15%, espec i ely (X2=4.90, p<0.05). Di e en ia ion o calci ica ions by cha ac e in o
linea and lumpy. Showed ha linea shadows o calci ica ions a e associa ed wi h in a-duc al
b eas cance (61.54% agains 26.92% o lumpy o ma ions), while in he case o benign
pa hology, lumpy calci ica ions a e mo e o en de ec ed (50.85% agains 19.49% o linea
calci ica ions, X2 be ween b eas cance g oups and benign pa hology=19.18, p<0.001).
Thus, he analysis showed ha he sensi i i y o mammog aphy in he aspec o de ec ing
in aduc al o ma ions is 83.33%. In he aspec o di e en ia ed de ec ion o malignancy,
in o ma i e mammog aphic signs u ned ou o be de o mi y o he X- ay pa e n and de ec ion o
linea calci ica ions. The emaining mammog aphic cha ac e is ics did no di e in he case o
malignan and benign pa hology.
The sensi i i y o such a mammog aphic sign as pa e n de o mi y in he aspec o de ec ing
in aduc al b eas cance is 42.31% (11 ou o 26), speci ici y is 85.59% (101 ou o 118), and
diagnos ic alue is 77.78% (112 ou 144). The ela i e isk o de ec ing in aduc al malignancy in
pa ien s wi h mammog aphic pa e n de o mi y is 3.04 (absolu e isk o in aduc al b eas cance
in pa ien s wi h pa e n de o mi y is 39.29%: 11 ou o 28, in pa ien s wi hou pa e n de o mi y-
12.93%: 15 ou o 116, X2e=9.97, p<0.01).
The sensi i i y o calci ica ion de ec ion o he isk o duc al b eas cance is 73.08% (19
ou o 26), he speci ici y is 50.85% (60 ou o 118), and he diagnos ic e ec i eness is 54.86%
(79 ou o 144). The isk o duc al b eas cance in pa ien s wi h b eas calci ica ions diagnosed by
mammog aphy is 24.68% (19 ou o 77), in he absence o calci ica ions-10.45% (7 ou o 67, chi
squa e=4.99, p<0.05), so he ela i e isk o b eas cance in he gland wi h mammog aphically
de ec able calci ica ions is 2.36.
De ec ion o linea calci ica ions (39 cases ou o 144) is cha ac e ized by sensi i i y o
61.54% (16 ou o 26), speci ici y-80.51% (95 ou o 118), diagnos ic signi icance – 77.08% (111
ou o 144). The isk o duc al b eas cance in he case o linea calci ica ions de ec ed du ing
sc eening mammog aphy is 41.03% (16 ou o 39), wi hou linea calci ica ions-9.52% (10 ou o
105, X2=18.51, p<0.001), he ela i e isk o duc al b eas cance in he case o linea calci ica ions
is 4.31. Thus, he de ec ion o linea calci ica ions in he aspec o diagnosing duc al b eas cance ,
compa ed wi h he de ec ion o calci ica ions o any o m, is associa ed wi h an inc ease in
speci ici y wi h a dec ease in sensi i i y.
CONCLUSION
C i e ia
B eas cance
c i e ion (n=26)
Benign
pa hology (n=118)
Mammog aphy+ (n=67)
10 (38,46%)
57 (48,31%)
Clinic+ (n=24)
5 (19,23%)
19 (16,10%)
Mammog aphy+ / clinic+ (n=53)
11 (42,31%)
42 (35,59%)
X2
0.83 nd
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1. The sensi i i y o clinical physical sc eening o in aduc al b eas o ma ions is 53.47%,
he sensi i i y o mammog aphic sc eening is 83.33%.
3. Mammog aphic ma ke s o malignancy o an in aduc al o ma ions a e de o ma ion o
he b eas pa e n (RR = 3.04, p < 0.01), he p esence o calci ica ions (RR = 2.36, p < 0.05), in
pa icula linea calci ica ions (RR = 4.31, p < 0.001).
REFERENCES
1. Bluekens AM, Holland R, Ka ssemeije N, B oede s MJ, den Hee en GJ. Compa ison o
digi al sc eening mammog aphy and sc een- ilm mammog aphy in he ea ly de ec ion o
clinically ele an cance s: a mul icen e s udy. Radiology. 2012;
2. B ay F, Fe lay J and Soe joma a am I, e al. Global cance s a is ics 2018;
3. Taglia ico AS, Calab ese M, Ma isco i G, Du ando M, Tos o S, Mone i F, e al. Adjunc
sc eening wi h omosyn hesis o ul asound in women wi h mammog aphy-nega i e dense
b eas s: in e im epo o a p ospec i e compa a i e ial. J Clin Oncol. 2016;
4. Pisano ED, Ga sonis C, Hend ick E, Ya e M, Baum JK, Acha yya S, e al. Diagnos ic
pe o mance o digi al e sus ilm mammog aphy o b eas -cance sc eening. N Engl J Med.
2005;
5. Riedl CC, Lu N, Be nha C, Webe M, Be na ho a M, Tea MK, e al. T iple-modali y
sc eening ial o amilial b eas cance unde lines he impo ance o magne ic esonance
imaging and ques ions he ole o mammog aphy and ul asound ega dless o pa ien
mu a ion s a us, age, and b eas densi y. J Clin Oncol. 2015;
6. Taglia ico AS, Calab ese M, Ma isco i G, Du ando M, Tos o S, Mone i F, e al. Adjunc
sc eening wi h omosyn hesis o ul asound in women wi h mammog aphy-nega i e dense
b eas s: in e im epo o a p ospec i e compa a i e ial. J Clin Oncol. 2016.
