177Lu Anonymized Pa ien Da ase s
Lu-177 SPECT Time In eg a ed Ac i i y Maps
Acknowledgemen Reques o Published Use:
We ask ha anyone using his da a o publica ions/p esen a ions acknowledge his as ollows:
“We acknowledge Yuni Dewa aja a he Uni e si y o Michigan o p o iding access o Lu-177
pa ien imaging da a and segmen a ions ob ained wi h suppo om R01EB022075 awa ded by
NIBIB and R01CA240706 awa ded by NCI, NIH. Da a we e sha ed ia he Uni e si y o Michigan
Deep Blue Da a sha ing eposi o y.”
The pa ien da a sha ed is o be used o pu poses o esea ch only as indica ed in he License ile. Any
use o comme cial pu poses is no pe mi ed a his ime.
In oduc ion:
In e nally adminis e ed a ge ed adionuclide he apy (TRT) wi h adio-labelled a ge ing
molecules ha deli e cy o oxic adia ion o umo has been used success ully o ea
mul iple cance s. Lu-177, used inc easingly in TRT, emi s bo h be a pa icles ha deli e he
he apeu ic e ec and gamma- ays ha a e sui able o SPECT imaging.
The FDA ecen ly app o ed a ixed ac i i y egimen (4 cycles o 7.4 GBq/cycle as in NETTER -1
adminis e ed e e y 8 weeks) Lu177 DOTATATE TRT o neu oendoc ine umo . Fo pa ien s
unde his s anda d ea men a Uni e si y o Michigan, we pe o med SPECT/CT imaging a 4
ime poin s a e Cycle 1 o 2 wi h he goal o pe o ming highly pa ien speci ic dosime y o
es ablish dose- esponse ela ionships.
Co esponding olume o in e es (o gans, lesions) con ou s we e de ined manually by a
adiologis (lesions) o a echnologis (o gans) using semi-au oma ic ools. Fo 2 pa ien s we
sha e he e baseline diagnos ic imaging scans, mul i- ime poin plana and SPECT/CT imaging
da a, ime-in eg a ed ac i i y images and segmen ed VOIs.
File Desc ip ions:
This publica ion con ains anonymized diagnos ic imaging scans o wo pa ien s who ha e li e
cance . The images a e pos -p ocessed combina ions o 4 SPECT scans, all aken wi hin 8 days o
he pa ien s ecei ing a he apeu ic dose o Lu a he a. The pos - he apy single-pho on emission
compu ed omog aphy (SPECT) scans a e used clinically by he physician o iden i y he
adionuclide dose dis ibu ion h oughou he body and acqui ed on a Siemens In e o sys em
and econs uc ed using xSPECT Quan . The combina ion o hese SPECT scans in o a single
ime-in eg a ed ac i i y map gi es a obus , oxel le el iew o he 177Lu ac i i y dis ibu ion o e
he cou se o ea men .
This map was gene a ed ia he MIM MRT Dosime y package: The 4 ime poin s we e
egis e ed o he e e ence SPECT scan ( ime poin 1) using a con ou in ensi y based SPECT
alignmen and he oxel-le el ime-ac i i y da a was i using exponen ial unc ions. Voxel-le el
in eg a ion was pe o med o gene a e he TIA map. The uni s o his image is Bq/mL * sec.
The publica ion is di ided in o 2 main olde s, one o each pa ien . Bo h pa ien s ha e a single
olde con aining he slice-by-slice DICOM iles. All scans a e windowed a ound he abdominal
egion o include he en i e li e and any o he me as a ic disease he pa ien had a he ime o
ea men .
Collec ion In o ma ion:
This collec ion is comp ised o a numbe o wo ks ha collec i ely ep esen he imaging s udies
and in o ma ion necessa y o dosime ic analysis o a pa ien ea ed wi h Lu a he a. All wo ks
may be used as s andalone da ase s o in conjunc ion wi h he o he s in his collec ion
depending on he analysis pe o med.
Files a e s o ed using he DICOM s anda d widely accep ed o s o age and ansmission o
medical images and ela ed in o ma ion. All pa ien p i a e in o ma ion has been anonymized
using MIM comme cial so wa e (MIM So wa e Inc.).
Da a om 2 pa ien s, e e ed o as pa ien 4 and pa ien 6, has been p o ided in his collec ion
and is di ided among 6 wo ks as ou lined below:
1) P e- he apy Diagnos ic Images
Desc ip ion:
Pa ien diagnos ic scans pe o med p io o Lu a he a ea men . Used o
iden i ying lesions and measu ing p og ession. No e ha he da e o he
baseline scan may be se e al mon hs be o e he Lu a he a ea men and
changes in he ana omy a e possible.
Files:
(1) Ga68 Do a a e PET/CT
Ei he :
(1) MRI
(1) s andalone diagnos ic CT
2) Mul i-Time Poin Lu-177 Plana Whole Body Scans
Desc ip ion:
Plana whole body Lu-177 scans aken a 4 ime poin s wi hin he 8 days a e
ea men . Two iews (An e io and Pos e io ) and 3 ene gy windows (one main
window a 208 keV and 2 adjacen sca e windows) a e a ailable o each ime
poin . The uni s o his image is coun s. Ene gy window in o ma ion, acquisi ion
da a/ ime and du a ion can be ound in DICOM heade .
Files:
(6) indi idual images a each ime poin (24 o al images pe pa ien )
3) Mul i-Time Poin Lu-177 SPECT/CT Scans
Lu-177 SPECT/CT scans a 4 ime poin s wi hin he 8 days a e ea men (same
ime poin s as he plana scans). Images we e acqui ed on a Siemens In e o
sys em and econs uc ed using xSPECT Quan . The uni s o his image is
Bq/mL. In o ma ion on he econs uc ion, acquisi ion da e/ ime, du a ion, Lu-
177 adminis a ion ime and ac i i y can be ound in he DICOM heade .
Files:
(1) Folde wi h econs uc ed SPECT slices pe ime poin (4 olde s o al pe
pa ien )
(1) Folde con aining egis e ed CT slices pe ime poin (4 olde s o al pe
pa ien )
4) Lesion and O gan Volumes o In e es
Desc ip ion:
DICOM RT s uc u e iles con aining o gan and lesion olumes o in e es (VOI)
ha a e egis e ed o he SPECT acquisi ion a each o he 4 ime poin s in 3).
Full con ou Boolean masks we e c ea ed o each o he de ined s uc u es.
O gans we e de ined using semi-au oma ic ools (a las based and CNN-based)
while lesions we e de ined manually by a adiologis guided by baseline scans.
Only lesions >2 cc we e de ined.
Files:
(1) Folde wi h o gan con ou s pe ime poin (4 olde s o al pe
pa ien )
(1) Folde wi h lesion con ou s pe ime poin (4 olde s o al pe
pa ien )
(1) Folde wi h o gan Boolean masks pe ime poin (4 olde s o al pe
pa ien )
(1) Folde wi h lesion Boolean masks pe ime poin (4 olde s o al pe
pa ien )
5) Lu-177 SPECT Time In eg a ed Ac i i y Maps
Desc ip ion:
A DICOM ile con aining he ime-in eg a ed ac i i y map o e all 4 ime poin s
wi hin he 8 days a e ea men . This combines he SPECT/CT scans p o ided
in 3) in o a single in eg a ed ac i i y map. This map was gene a ed ia he MIM
MRT Dosime y package: The 4 ime poin s we e egis e ed o he e e ence
SPECT scan ( ime poin 1) using a con ou in ensi y based SPECT alignmen and
he oxel-le el ime-ac i i y da a was i using exponen ial unc ions. Voxel-le el
in eg a ion was pe o med o gene a e he TIA map. The uni s o his image is
Bq/mL * sec
Files:
(1) Folde wi h Time-in eg a ed ac i i y image pe pa ien
6) Lu-177 SPECT P ojec ion Da a and CT-based A enua ion Coe icien Maps
Desc ip ion:
SPECT p ojec ion da a o each o he 4 Lu a he a scans aken wi hin he 8 days
a e ea men is p o ided in 3 o ms: unal e ed, Siemens [Re o ma ed], and
Siemens [Ad anced]. The di e ence be ween he P ojec ions and he
[Ad anced] P ojec ions is ha he [Ad anced] consis s o unco ec ed aw
p ojec ion da a and he o he he co ec ed p ojec ion da a (e.g. came a
uni o mi y co ec ions). The [Ad anced] p ojec ions a e used in xSPECT
econs uc ion (whe e all co ec ions a e done du ing he econs uc ion), while
he o he is used in Flash 3D econs uc ion.
CT-based a enua ion coe icien maps (mumaps) a e p o ided o each o he 4
scans aken wi hin he 8 days a e ea men . Two me hods a e p o ided o
each mumap: xSPECT and F3D as he ma ix size is di e en o he 2 cases
(256 x 256 o xSPECT and 128 x 128 o Flash3D).
Files:
(3) Folde s con aining aw SPECT p ojec ions
(2) Folde s con aining CT a enua ion coe icien maps (mumaps)
Addi ional In o ma ion:
Pa ien 4:
Pa ien 4 is a 64 y old male wi h he anonymized pa ien ID ANON54121
177Lu Injec ed Ac i i y: 7.21 GBq
177Lu Time/da e o Injec ion: 15NOV2018 09:22 AM
Imaging p o ided a 4 ime poin s ollowing Cycle 2 o Lu a he a
Two lesions we e iden i ied and ou lined by a adiologis as >2cc o his pa ien . These
a e isually iden i ied in he images below. O he lesions may be p esen , bu a e no
included in his publica ion.
Pa ien 6:
Pa ien 6 is a 63 y old emale wi h he anonymized pa ien ID ANON60350
177Lu Injec ed Ac i i y: 7.31 GBq
177Lu Time/da e o Injec ion: 15MAY2019 09:55 AM
Imaging p o ided a 4 ime poin s ollowing Cycle 1 o Lu a he a.
Pa ien has no spleen.
Fou lesions we e iden i ied and ou lined by a adiologis o his pa ien . These a e
isually iden i ied in he images below. O he lesions may be p esen , bu a e no
included in his publica ion.
In o ma ion on scan da a/ ime, acquisi ion ime, ma ix size, pixel size, econs uc ion
me hod/pa ame e s e c. a e a ailable on he DICOM heade o hese iles. Only Pe sonal Heal h
In o ma ion (PHI) we e emo ed du ing he anonymiza ion.
Glossa y:
DICOM Naming:
The se ies desc ip ion o he DICOM iles p o ided include an indexing code in hei
olde o ile names o easy iden i ica ion o which scan hey belong o.
C[x]S[y]D[z]
C[x] e e s o he Lu a he a cycle. Lu a he a is adminis e ed in 4 cycles o he pa ien s
in his publica ion and a he momen his collec ion only p o ides scan da a o a single
cycle o each pa ien , which is cycle 1 o pa ien 6 and cycle 2 o pa ien 4.
S[y] e e s o he scan numbe . Fou scans a e aken a e each ea men cycle and all 4
scans a e p o ided in his publica ion.
D[z] e e s o he day he scan was aken on. Days a e numbe ed om 0 (day o
Lu a he a ea men ) o 8 (8 days a e ea men ).
Rela ed Ma e ials:
Publica ions:
Ou publica ions ela ed o abo e da a ha may ha e addi ional in o ma ion you a e
looking o a e lis ed below. Howe e , no e ha in some cases in-house de eloped
algo i hms we e used o econs uc ion while all images in his eposi o y we e
econs uc ed using clinic so wa e.
1) The esa P De asia, Yuni K Dewa aja, Ki k A F ey, Ka Ki Wong, Ma hew J Schippe . A
no el ime-ac i i y in o ma ion sha ing app oach using nonlinea mixed models o
pa ien -speci ic dosime y wi h educed imaging ime poin s: applica ion in
SPECT/CT imaging pos -177Lu-DOTATATE. J Nuc Med 2020
h ps://doi.o g/10.2967/jnumed.120.256255.
2) Mi ando D, Dewa aja, YK, Cole NM, Nelson AS. In pu sui o ully au oma ed
dosime y: e alua ion o an au oma ic VOI p opaga ion algo i hm using con ou
in ensi y-based SPECT alignmen . Eu J Nucl Med Mol Imaging. 2020;47(Suppl 1):
S236.
Da ase s:
O he da ase s cu en ly e e enced in his eadme, o u u e wo ks published in he
Uni e si y o Michigan Deep Blue Da a eposi o y can be loca ed ia he Deep Blue Da a
downloads page o his wo k. Look o he “Rela ionships” o “Ci a ions o ela ed
ma e ial” a ibu es on he downloads page o documen s ela ed o his publica ion.
DOI’s o he cu en ly associa ed wo ks a e also lis ed below:
P e- he apy Diagnos ic Images
DOI: h ps://doi.o g/10.7302/ qmy-g059
Mul i-Time Poin Lu-177 SPECT/CT Scans
DOI: h ps://doi.o g/10.7302/0n8e- z46
Lesion and O gan Volumes o In e es
DOI: h ps://doi.o g/10.7302/ h h-qg23
Mul i-Time Poin Lu-177 Plana Whole Body Scans
DOI: h ps://doi.o g/10.7302/y4xd-s758
Lu-177 SPECT P ojec ion Da a and CT-based A enua ion Coe icien Maps
DOI: h ps://doi.o g/10.7302/c cw-6s13
This publica ion may be ci ed as ollows:
Dewa aja, YK., Van, BJ. (2021) Lu-177 DOTATATE Anonymized Pa ien Da ase s:
Lu-177 SPECT Time In eg a ed Ac i i y Maps [Da a se ]. Uni e si y o Michigan -
Deep Blue. h ps://doi.o g/10.7302/9nc -bk44.
