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The Sa e-and-Sus ainable-by-Design app oach o
al e na i e me al- ee wound d essings in NABIHEAL
Julia Voglhube -Hölle 1, Cai lin Ahe n1, Johanna K. Schepe 1
1BioNanoNe Fo schungsgesellscha mbH (BNN), Aus ia
NABIHEAL Objec i e
To acili a e he de elopmen o a sa e( ) and mo e sus ainable wound d essing by applying a Sa e-and-Sus ainable-by-Design app oach in he ea ly inno a ion phase.
The NABIHEAL p oduc will be a me al- ee al e na i e o an i-mic obial and wound-healing p omo ing wound d essings.
johanna.schepe @bnn.a
This p ojec has ecei ed
unding om he Eu opean
Union’s Ho izon Eu ope
esea ch and inno a ion
p og am unde g an
ag eemen n°101092269.
Ch ounic wounds, Wound healing p ocess and S anda d-o -Ca e.
Ch onic wounds a e cha ac e ized by pe sis ence o e mo e han 6 weeks despi e
ac i e in e en ion and while showing no signi ican p og ession owa ds closu e
and healing. Such p oblema ic wounds p esen in up o 2% o he popula ion in
indus ialized coun ies [1, 2, 3]. This no only bu dens indi idual pa ien s bu also
s ains public heal h sys ems, accoun ing o up o 4% o he o al heal hca e
budge in Eu ope [2, 3]. Na u ally, he g a es conce n in ega d o non-healing
wounds is he high isk o in ec ion wi h mic obes. Cu en s anda d-o -ca e
ea men s ely hea ily on sil e -based agen s, despi e hei limi ed e icacy, as
p o en by he e ogenous ou comes o clinical ials, en i onmen al impac , and
cos liness [4].
Figu e 1: The ou s ages o he wound-healing p ocess and co esponding ime scale. (DOI:10.1007/s10787-023-01318-6)
12The Sa e-and-Sus ainable-by-Design applied in he nanomedical ield.
NABIHEAL unde s ands sus ainable de elopmen in is h ee dimensions:sa e y,
en i onmen al and socio-economic. The me hodology applied by he p ojec
ad ances scien i ic knowledge and inno a ion and upholds p inciples c ucial o
sa e and sus ainable biomedical esea ch. By in eg a ing SSbD p inciples
h oughou he whole inno a ion p ocess, NABIHEAL con ibu es o he
de elopmen o sa e and mo e e ec i e ea men s while p omo ing
en i onmen al s ewa dship and socio-economic in eg i y in he biomedical
sciences.
Figu e 2: Phases o he de elopmen o a nanomedical p oduc and how o implemen he SSbD app oach.
3Me hods & App oach in NABIHEAL.
•P ojec - ailo ed SSbD concep de elopmen and implemen a ion.
•Tie ed and hie a chical app oach
→ ollowing and aligned wi h he JRC SSbD amewo k [5]
•Tailo ed ques ionnai es on (i) ma e ials used/p oduced and (ii) o p oduc ion and
manu ac u ing p ocesses de eloped and implemen ed a he s a o he p ojec
and e iewed a di e en imes du ing he p ojec li e ime. Ques ionnai es builds
on p e ious wo k om
→ Ea ly4AdMa [6] & SUNSHINE [7] p ojec s
→ Labo a o y isi s
→ Bila e al mee ings wi h all ac o s in ol ed in he p ojec
•Special ocus on nano-sa e y issues and egula o y aspec s o be add essed
•Fo mula ion o speci ic ecommenda ions
•Compa ison o s anda d-o -ca e wound ca e ma e ials
4Resul s o ini ial SSbD assessmen om S ep 1.
Unce ain y o in e nal
haza d was a he high o
NABIHEAL componen s, bu
jus i ied due he ea ly p ojec
s a us. Howe e , i should be
no ed ha componen s a e
well cha ac e ized on a
physicochemical le el.
Rega ding human and
en i onmen al sa e y aspec s
NABIHEAL componen s we e
compa ed o he s anda d o
ca e wi h he goal o
ul ima ely su passing hem in
sco ing.
C
B
A
5SSbD p inciple implemen a ion among pa ne s
Implemen ed (blue), desi ed (whi e), deemed un easible (beige) o i ele an
(g ey) by echnical pa ne s (n=12) a mon h 12.
SSbD p inciple
ICMAB NT BIO CH
HCELL UM MyB UGR
IMROH UEX AU IT
ICMAB NT BIO CH
HCELL UM MyB UGR
IMROH UEX AU IT
ICMAB NT BIO CH
HCELL UM MyB UGR
IMROH UEX AU IT
ICMAB NT BIO CH
HCELL UM MyB UGR
IMROH UEX AU IT
ICMAB NT BIO CH
HCELL UM MyB UGR
IMROH UEX AU IT
ICMAB NT BIO CH
HCELL UM MyB UGR
IMROH UEX AU IT
ICMAB NT BIO CH
HCELL UM MyB UGR
IMROH UEX AU IT
ICMAB NT BIO CH
HCELL UM MyB UGR
IMROH UEX AU IT
M12
SSbD1 Ma e ial e iciency
SSbD2 Minimise he use o haza dous
chemicals/ma e ials
SSbD3 Design o ene gy e iciency
SSbD4 Use o enewable sou ces
SSbD5 P e en and a oid haza dous emissions
SSbD6 Reduce exposu e o haza dous subs ances
SSbD7 Design o end-o -li e
SSbD8 Conside he whole li e cycle
Ou come and nex s eps
This i e a i e app oach moni o s he p og ess o NABIHEAL and s ee s he p ojec in a desi able di ec ion in e ms o sa e y and sus ainabili y. By implemen ing hese
ac ions, we con ibu e o he de elopmen o inno a i e SSbD echnologies o wound d essings, alle ia ing he bu den o ch onic wounds on a ec ed pa ien s as well as
heal hca e sys ems. Addi ionally o he bene i s p o ided o NABIHEAL, his SSbD concep , one o he i s cases in he medical sec o , will p o ide aluable insigh s and
lea ning ou comes o imp o ed SSbD implemen a ion in u u e p ojec s and de elopmen s.
Re e ences
[1] F ykbe g e al. Ad Wound Ca e (New Rochelle). 2015 /// [2] Phillips e al. In Wound J. 2016 /// [3] Go up. The Ame ican Jou nal o Su ge y. 2004 /// [4] Wilkins e al. Ad Skin Wound Ca e. 2013 /// [5] Caldei a e al. Publica ions O ice o he Eu opean Union. 2022 /// [6] OECD. EHS, En i onmen
Di ec o a e. 2023 /// [7] Pizzol e al. Cleane En i onmen al Sys ems. 2023
.
