GA n°101092269 1
This p ojec has ecei ed unding om he
Eu opean Union’s Ho izon Eu ope esea ch
and inno a ion p og amme unde g an
ag eemen n°101092269.
The Sa e-and-Sus ainable-by-Design app oach o al e na i e
me al- ee wound d essings in NABIHEAL
M . And eas Falk
CEO
BioNanoNe Fo schungsgesellscha mbH
GA n°101092269 2
The Nabiheal P ojec
Some numbe s & ac s
The SSbD App oach
Ta ge ed app oach
Resul s
Fi s indings
Impac
Economic, En i onmen al & Social
01
02
04
03
01
GA n°101092269 3
Nabiheal P ojec
01
An imic obial nanos uc u ed bioma e ial o complex wound healing
GA n°101092269 4
Nabiheal P ojec Pa ne s
01
5SMEs
4RTOs
4Uni e si ies
1Hospi al
GA n°101092269 5
Backg ound & Needs and Solu ion
01
Complex wounds a e a global heal h p oblem wi h signi ican
impac on he heal h ca e economy. In de eloped coun ies alone,
hey impac he quali y o li e o mo e han 2% o o al popula ion.
Complex wounds, including ch onic wounds o majo bu ns, a e
highly suscep ible o mic obial in ec ion and bio ilm o ma ion,
and di icul o ea . Mo eo e , sil e is a widely used me al in
an imic obial p oduc s o ea wound in ec ions. Howe e , sil e -
based p oduc s a e expensi e, and show se e al d awbacks due o
cos s, as well as en i onmen al and sa e y conce ns.
The ou s ages o he wound-healing p ocess and co esponding ime scale.
(DOI:10.1007/s10787-023-01318-6)
The NABIHEAL p ojec will de elop mul i unc ional bioma e ials,
om p oo -o -concep (TRL 3) o he p eclinical egula o y s age
(TRL 5), o imp o e wound managemen . The esul ing
bioma e ials will enable a o dable ea men o wound in ec ions
o p e en ion o complica ions du ing all phases o he wound
healing p ocess.
S ages o healing wi h NABIHEAL mul i unc ional bioma e ials
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Nabiheal Wo k Plan
01
GA n°101092269 7
02 SSbD App oach
Phases o he de elopmen o a nanomedical p oduc and how o implemen he SSbD app oach.
NABIHEAL unde s ands sus ainable de elopmen in i s
h ee dimensions: sa e y, en i onmen al and socio-
economic.
The me hodology applied by he p ojec ad ances
scien i ic knowledge and inno a ion and upholds
p inciples c ucial o sa e and sus ainable biomedical
esea ch.
By in eg a ing SSbD p inciples h oughou he whole
inno a ion p ocess, NABIHEAL con ibu es o he
de elopmen o sa e and mo e e ec i e ea men s
while p omo ing en i onmen al s ewa dship and socio-
economic in eg i y in he biomedical sciences.
GA n°101092269 8
•Nabiheal’s ailo ed SSbD ie ed and hie a chical app oach and implemen a ion ollows he JRC SSbD
amewo k
•Tailo ed ques ionnai es on (i) ma e ials used/p oduced and (ii) o p oduc ion and manu ac u ing p ocesses
we e de eloped and implemen ed a he s a o he p ojec and will be e iewed a di e en imes du ing
he p ojec li e ime. Ques ionnai es builds on:
1) Ea ly4AdMa & SUNSHINE p ojec s
2) Labo a o y isi s
3) Bila e al mee ings wi h all ac o s in ol ed in he p ojec
•Special ocus on nano-sa e y issues and egula o y aspec s a e add essed
•Fo mula ion o speci ic ecommenda ions a e p o ided
•Compa ison o s anda d-o -ca e wound ca e ma e ials is p o ided
02 Me hodology used
GA n°101092269 9
03 Resul s - ini ial SSbD assessmen om S ep 1
Unce ain y o in e nal haza d was a he high o NABIHEAL
componen s, bu jus i ied due he ea ly p ojec s a us.
Howe e , i should be no ed ha componen s a e well
cha ac e ized on a physicochemical le el. Rega ding human
and en i onmen al sa e y aspec s NABIHEAL componen s
we e compa ed o he s anda d o ca e wi h he goal o
ul ima ely su passing hem in sco ing.
●Ou come
Nabiheal componen s on a good way o
ca ching up al eady wi h SoC
●Challenges
In o ma ion a ailabili y o SoC (which
componen s + in o on componen s)
