Pe malink
Pos e Session
We G anula ion In es iga ed in Real-Time Using Synch o on-Based Dynamic
Mic o omog aphy (375)
Pa o :
Pos e Session (Tuesday)
In o
A ilia ion:
Academia - G adua e S uden
Selec you heme:
Applica ions
Topic Lis :
(Applica ions) Bio echnology and Applica ions o Heal h
O al o Pos e P esen a ion:
O al P esen a ion
S uden Awa ds Eligibili y:
G adua e S uden Awa ds
Abs ac Tex :
We g anula ion, he mos widesp ead me hod o pha maceu ical g anula ion, is an a ea o in e es in pha maceu ical
esea ch wi h a en ion owa ds he e ol ing g anule po osi y. Al hough he g anule’s changing ex e nal s uc u es
ha e been s udied ex ensi ely, i is much mo e di icul o s udy he changing in e nal s uc u es. The g anule is
opaque so di ec obse a ions canno be made, and he g anula ion p ocess is on he o de seconds which equi es
ul a as da a acquisi ion. The synch o on-based dynamic mic o omog aphy (µCT) echnique can p o ide non-
des uc i e and sub-second da a acquisi ion. This echnique was used o in es iga e we g anula ion and e ealed
new insigh s by analyzing he e ol ing mic os uc u es.
Lac ose monohyd a e (LMH) was used as a ep esen a i e pha maceu ical powde . D y powde s we e loaded in o a
con aine and placed on o a o a ion s age which ope a ed a a cons an speed o 360 deg/sec. A 2.5 µL d ople o
deionized wa e was eleased om 1.5 cm abo e he o a ing powde bed and a single g anule o med. Dynamic-µCT
Tue, Oc obe 25 Exhibi ion Hall A Pos e
10/6/24, 4:05 PM
CCEC 2022 - 72nd Canadian Chemical Enginee ing Con e ence
h ps://www.xcdsys em.com/cic/p og am/5iXyWiQ/index.c m?pgid=2778&sid=25672&abid=95190
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was used o scan he changing in e nal s uc u es o he g anule in-si u o 20 sec a a a e o one CT e e y 0.5 sec.
CT is a h ee-dimensional (3D) echnique and 3D ende s o he g anule mic os uc u e quan i ied indi idual po es,
ne wo ks o po es, and o al po es e ol ing in eal- ime. The mean po e olume om = 8 o 20 sec inc eased om
2.8 o 6.8 mm . The o al numbe o po es luc ua ed, bu he o al olume consis en ly inc eased, sugges ing ha
indi idual po es consolida ed in o ne wo ks o e ime. Las ly, g anule po osi y inc eased om 1.9 o 8.8 % o e he
obse ed ime pe iod.
This s udy quan i ied he changing g anule po osi y in eal- ime. This is a key accomplishmen owa ds unde s anding
he ac o s ha in luence g anule po osi y which in u n, in luences pha maceu ical pe o mance. Howe e , he
li e a u e has epo ed he po osi y o d y g anules o simila pha maceu ical ma e ials o be a ound 12-15%. This
disc epancy could be because 20 sec o scanning did no ully cap u e he e ol ing po es un il he end. One way o
ex ending he scanning ime would be o use a smalle ield-o - iew (FOV). Since he da a size o each image can be
calcula ed om he FOV, i limi s he o al numbe o images ha can be sa ed in one scan which in u n, limi s he
o al scan ime. Success ul dynamic CT scans equi e ca e ul conside a ion o how imaging pa ame e s i.e., FOV,
exposu e ime, o a ion speed, and memo y among o he s, wo k in andem and es ic each o he .
Dynamic-µCT is a powe ul echnique o in es iga ing changing mic os uc u es and he success in in es iga ing a
single ma e ial can lead owa ds mo e complex pha maceu ical o mula ions. By conside ing all pa ame e s,
expe imen al and imaging, obus dynamic-µCT p ocedu es can be designed o mo e complex we g anula ion
s udies. The demons a ions o his s udy we e o we g anula ion, bu he app oach can also be used in simila ly as
occu ing phenomenon in chemical enginee ing esea ch. Recen li e a u e has shown en husiasm in s udying he
dynamics o colloidal sys ems, deg ading ma e ial, and ood sciences.
Au ho s
3
Xiao Fan Ding
Uni e si y o Saska chewan
Sima Zeinali
Uni e si y o Saska chewan
Li eng Zhang, MCIC
P o esso
Uni e si y o Saska chewan
Ning Zhu
Biomedical Imaging and The apy (BMIT) Beamline, Canadian Ligh Sou ce
10/6/24, 4:05 PM
CCEC 2022 - 72nd Canadian Chemical Enginee ing Con e ence
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