NEWSLETTER
NO. 2 –SEPTEMBER 2023
Dea colleague,
One yea o REPO4EU!
Thank you o you con inuous suppo and in e es . I would like o ake his
oppo uni y o upda e you on ou la es achie emen s and p o ide some mo e
de ails on exci ing new hings on he ho izon. Toge he , we wan o make a
p o ound change o medicine and pa ien bene i . Read on o ind ou how.
P o , Ha ald Schmid
MD, PhD, Pha mD
Coo dina o o REPO4EU – Maas ich Uni e si y
Las yea 's RExPO22 -ou in e disciplina y d ug epu posing con e ence in
Maas ich spanning bioin o ma ics, diagnos ics and inno a i e clinical ials,
pa en ing, egula o y and business de elopmen - was a majo success and
buil a s ong Eu opean communi y. One yea la e , RExPO is now mo ing o
Sweden and going global. Co-chai ed by Ha ald Schmid and Paolo Pa ini, he
con e ence will hos global playe s in d ug epu posing om he Ame icas,
Asia and Aus alia. We a e looking o wa d o seeing you a RExPO23 in
S ockholm - click below o all he de ails on he agenda, egis a ion, abs ac
submission, ip logis ics... and mo e!
I is RExPO ime again – wha a e you wai ing o ?
THIS IS RExPO23THIS IS RExPO23
Join ou d ug epu posing communi y
REPO4EU On Tou , ou ongoing se ies o na ional e en s wi h communi y ge -
oge he s in Spain, Po ugal, G eece and Ge many so a , is li ing p oo o ou
unwa e ing commi men o dig deep in o each coun y's d ug epu posing
scene, and liaise wi h key ac o s, such as he RepOG egula o g oup. As a
esul , we ha e onboa ded se e al new membe s o ou REPO4EU communi y
and ad iso y boa ds o expe insigh s and ma chmaking. Sounds
in e es ing? You a e welcome o join us - check ou ou communi y page
below and each ou i you wan o ge lis ed!
BECOME A MEMBERBECOME A MEMBER
A REPO4EU we a e highly commi ed o Open Science in he way we
app oach he dissemina ion o ou p ojec -speci ic ools and esou ces - om
whi epape s o key scien i ic esul s s emming om ou pla o m’s alida ion
pilo s. In keeping wi h his philosophy, we ha e c ea ed D ug Repu posing
Cen al, a one-s op shop o e e y hing you e e wan ed o know abou d ug
epu posing and ou ne wo k medicine app oach. Hos ed on ScienceOpen,
his supe collec ion includes wo diamond open access jou nals (“D ug
Repu posing” and “Ne wo k Medicine”), oge he wi h a li e a u e collec ion
ha p o ides upda es on all de elopmen s in he ield o d ug epu posing
based on expe sea ch algo i hms. REPO4EU’s i s public deli e ables ha e
also been published. As a bonus, D ug Repu posing Cen al implemen s
Sci e.ai “sma ci a ions” badges, le e aging AI echnology o assess whe he
a ci a ion suppo s, men ions o con as s he ci ed claim.
Nex s op: D ug Repu posing Cen al
DISCOVER DRUG REPURPOSING CENTRALDISCOVER DRUG REPURPOSING CENTRAL
Ou collec ion o Knowledge Pills
D ug epu posing is such an in e disciplina y ield ha we hough long and
ha d abou how bes o highligh he co e p inciples ha d i e REPO4EU in an
accessible way. This is how ou Knowledge Pills ha e come o be: a se ies o
easily diges ible, highly e ec i e, bi e-sized pieces o con en packed in o
sho explaine ideos co e ing he key concep s and inno a ion o ou
p ojec : he why, he wha , he who and he how. Ha e a look ia he link
below and make su e o subsc ibe o mo e!
HAVE A KNOWLEDGE PILLHAVE A KNOWLEDGE PILL
Las May, he Eu opean Medicines
Agency Inno a ion Task Fo ce held
an online b ie ing mee ing wi h 12
key REPO4EU pa icipan s, 11 EMA
expe s and 4 ex e nal expe s o
discuss po en ial equi emen s o
clinical ials ollowing ou p ecision
medicine app oach o d ug
epu posing. They la gely ag eed
ha mechanism-based ne wo k
pha macology conside a ions migh
g ea ly educe he need o
p eclinical animal da a i
combina ions o low-dose app o ed
d ugs a e used, and ha Phase I
clinical ials in heal hy indi iduals
will no be necessa y in many cases.
Whe he condi ional app o al can be
gi en based on bioin o ma ics and
o he in silico da a will ha e o be
decided on a case-by-case basis.
Also back in May, ou coo dina o
isi ed REPO4EU's p ojec o ice ,
Monica Ensini, a he B ussels
o ice. Du ing he i id and
p oduc i e exchange, Monica was
ex emely app ecia i e abou ou
p ojec . She ei e a ed he high
hopes ha he Eu opean Heal h and
Digi al Execu i e Agency (HaDEA) is
in es ing in REPO4EU and ha he
eyes o many impo an o icials a e
on us o his eason.
The ac ha ou o gan-agnos ic
concep o medicine pu s inno a i e
science i s , and will de elop a
Eu opean d ug epu posing
in as uc u e only a he e y end,
ecei ed special a en ion.
Liaising wi h he EMA-ITF Insigh s om ou P ojec O ice
© REPO4EU 2023
