NEWSLETTER
NO. 1 –JANUARY 2023
Dea colleague,
Welcome o REPO4EU’s e y i s newsle e and hank you o you in e es in
ou wo k! Below, you will ind REPO4EU’s co e p inciples and miles ones we
ha e ocused on hese pas 5 mon hs since he p ojec s a ed.
Looking o wa d o a spec acula ly success ul 2023 le ing ou pa hs c oss!
Ha ald Schmid
COO REPO4EU
Maas ich Uni e si y
Abou REPO4EU
Why d ug epu posing?
Finding a new applica ion o a d ug ha is al eady on he ma ke educes he
ime and cos s o d ug de elopmen . I allows us o p io i ize pa ien bene i
and sa e y, as mos side e ec s a e al eady known.
Why mechanism-based?
Cu en ly, mos diseases a e de ined by symp oms in speci ic o gans. The e is
no unde s anding o i s molecula causes. This makes cu en app oaches o
d ug de elopmen (and d ug epu posing) isky and imp ecise. Thus, ou
pla o m combines all legal and business equi emen s o epu pose a d ug
wi h wo ld-class esea ch o comple ely ede ine diseases by hei molecula
causes, implemen ing p ecision diagnos ics o pa ien selec ion and selec ing
he op imal d ugs o ea he unde lying cause.
REPO4EU is he Eu o-Global Pla o m o Mechanism-Based D ug
Repu posing,an ambi ious ini ia i e ha we belie e will ushe in a p o ound
change o medicine and pa ien bene i .
Making connec ions a he s a o ou jou ney
Ou coo dina ion eam o ganised a e y success ul p ojec kick-o in
Maas ich , oge he wi h he RExPO22 con e ence.We also me
he RepoOG ope a ing g oup o Eu opean na ional egula o s on d ug
epu posing.
The oad so a …
Se ing he s age o he u u e o d ug epu posing
As pa o he p ojec ’s ounda ional wo k, we ha e s a ed
collec ing ools,da a sou ces and s anda ds ele an o d ug epu posing o
la e p io i isa ion and open access. Simila ly, and in o de o s eamline
p eclinical alida ion e o s, we ha e p epa ed an o e iew o accessible
da a,con ac s and e hical equi emen s o ge access o samples s o ed a
di e en Eu opean biobanks. This is essen ial o ain ou diagnos ics pla o m
echnology.
In pa allel, an in e nal baseline echnology eadiness assessmen has al eady
been ini ia ed o s a he build-up o RepoScope, a unique da abase making
epu posing- ele an pa en s and pee - e iewed pape s om 2010 onwa ds
a ailable in a use ul linked o m.
Real-wo ld da a-d i en A i icial In elligence
Ou AI expe s ha e de eloped a plan o a gene a i e s a is ical model ha
can p edic mechanis ic disease sub ype labels. The model can be ained in a
semi-supe ised way, using bo h labelled and unlabelled da a. This
echnology will be applied in ou upcoming REPO-HYPER clinical ial
o esis an hype ension.
Unlocking he ull po en ial o d ug epu posing clinical ials
REPO4EU has p oduced guidelines o conduc ing an ex ended eedom o
ope a e (F O) analysis and analysed all in ended clinical ials. REPO4EU
mainly enables academics ( he un apped esou ce) o pe o m and conside
all ele an s eps in d ug epu posing up o conduc ing a clinical phase II
(p oo o concep ) ial.
One o hese ials (REPO-HYPER) will be conduc ed a he Ka olinska
Ins i u e , S ockholm. An inqui y has al eady been p epa ed o he Swedish
componen au ho i y o his pu pose.
To gua an ee an e hics-by-
design p ocess, wo su eys ha e
been de eloped o map e hical and
da a p o ec ion issues. The pilo will
be applied o REPO-HYPER,
including he da a p o ec ion
challenges in Machine Lea ning-
assis ed pa ien sc eening.
Ou expe s ha e s a ed
b ains o ming on a whi e
pape on Heal h Technology
Assessmen (HTA) in d ug
epu posing. Feedback is now being
collec ed o ensu e a b oade iew
om all s akeholde s is adequa ely
in eg a ed wi hin REPO4EU.
E hics in he spo ligh A new ou look on HTA
Calling all s akeholde s - REPO4EU is an open pla o m!
REPO4EU in i es all key ac o s in d ug epu posing o be pa o ou pla o m
o ensu e i s inclusi eness and comple eness. We a e cu en ly de eloping
an open publishing po al, a chi ing and jou nal s uc u e o he en i e
communi y - ou collec ion on D ug Repu posing Resea ch publica ions on
ScienceOpen is al eady li e!
© REPO4EU 2023
This yea , we will also o ganize se e al na ional e en s o ge in di ec con ac
wi h local s akeholde s. The i s one is al eady unde way: i will ake place in
sunny Mad id his Ma ch. And ha ’s no all - many mo e exci ing oppo uni ies
a e on he ho izon! Na ional e en s in Munich and Vienna a e in p epa a ion.
The upcoming RExPO23 con e ence will be hos ed in S ockholm…and a US
edi ion o ou RExPO se ies is coming in 2024.
S ay uned - 2023 has jus begun!
