∗ Co esponding au ho : Aksha a Hi aman Ingale
Copy igh © 2025 Au ho (s) e ain he copy igh o his a icle. This a icle is published unde he e ms o he C ea i e Commons A ibu ion License 4.0.
Aksha a Hi aman Ingale 1, *, Reema Chand akan Londhe 2, P achi Nandkuma Padwal 2 and Mayu
Bapu ao Mesh am 1
1 S uden o Sama h Ins i u e o Pha macy, Belhe, Pune, Maha ash a, India.
2 Assis an p o esso o Sama h Ins i u e o Pha macy, Belhe, Pune, Maha ash a, India.
Wo ld Jou nal o Biology Pha macy and Heal h Sciences, 2025, 24(02), 043-048
Publica ion his o y: Recei ed on 24 Sep embe 2025; e ised on 01 No embe 2025; accep ed on 03 No embe 2025
A icle DOI: h ps://doi.o g/10.30574/wjbphs.2025.24.2.0968
Abs ac
Albendazole is an i-helmin hic d ug used o ea a a ie y o pa asi ic diso de s a ec ing he in es ines and issues by
p e en ing pa asi es om abso bing glucose and p oducing mic o ubules i wo ks. The pu pose o albendazole able
design is o op imize pa ien compliance, s abili y and bioa ailabili y. his e iew discusses se e al app oaches o
making and e alua ing albendazole able s wi h an emphasis on excipien selec ion manu ac u ing p ocesses and
quali y con ol measu es o e all he s udy shows a signi ican imp o emen in he apeu ic e ec i eness, s abili y and
dissolu ion a e, highligh ing he posi i e ou comes o de eloping success ul albendazole able s o mula ion.
Keywo ds: An helmin ic D ug; Albendazole; Table E alua ion; Ha dness; F iabili y; The apeu ic E ec i eness;
Asca iasis; Hookwo m
1. In oduc ion
Albendazole is a commonly used an helmin ic medica ion used o ea and p e en a a ie y o issue and in es inal
pa asi ic illnesses, including gia diasis, asca iasis, and hookwo m in ec ions. I wo ks by in e e ing wi h he pa asi e's
glucose abso p ion, which ul ima ely esul s in i s dea h, by dis up ing i s mic o ubule s uc u e. Albendazole is now a
widely ecommended medica ion in clinical p ac ice as well as public heal h campaigns because o i s b oad ange o
ac ions and demons a ed e icacy. I has g ea ly aided in he ea men o pa asi ic illnesses, which has helped o lowe
mo bidi y, aise pa ien heal h, and aise he s anda d o li ing o hose who a e a ec ed. Albendazole able s a e made
wi h he in en ion o making he medica ion e ec i e, s able, and simple o pa ien s o use. A numbe o s a egies, such
as me iculous excipien selec ion, manu ac u ing p ocess op imiza ion, and s ingen quali y con ol p ocedu es, all
con ibu e o ensu ing consis en d ug pe o mance and he apeu ic esul s. This e iew emphasizes he a ious
app oaches used in c ea ing and es ing albendazole able s, emphasizing ad ances made in p oduc ion, quali y
assu ance, and gene al e icacy. The e iew highligh s he signi icance o well-designed o mula ions in p o iding
albendazole able s ha a e bo h sa e and e ec i e by summa izing hese me hods.
Fo mula ion and e alua ion o albendazole able s d ug deli e y sys ems
Wo ld Jou nal o Biology Pha macy and Heal h Sciences, 2025, 24(02), 043-048
44
Figu e 1 Hookwo m In ec ion
Figu e 2 Asca iasis In ec ion
1.1. S uc u e o Albendazole
•IUPAC NAME: me hyl N-(6-p opylsul anyl-1H- benzimidazol-2-yl) ca bama e.
•Molecula Fo mula: C12 H15 N3O2S
•Molecula Weigh : 265.33 g/mol
2. Ma e ials and me hods
2.1. Ma e ial
Albendazole is equen ly p epa ed using excipien s like s a ch, dex ose, suc ose, and gela in, which se e as diluen s
and binde s. Calcium ca bona e (CaCO3), alc, anillin, and sodium bica bona e (NaHCO3) a e added o enhance pH
balance, s abili y, and low. These excipien s imp o e pala abili y and pa ien accep abili y as well. To maximize he
medicinal e ec i eness o albendazole o mula ions, such combina ions a e equen ly used.
Table 1 Ma e ials
S No.
Name o excipien s and API
1
Albendazole
2
S a ch
3
Dex ose
4
Gela in
5
Suc ose
6
Sodium Bica bona e
7
Talc
8
Vanillin
9
Calcium Ca bona e
Wo ld Jou nal o Biology Pha macy and Heal h Sciences, 2025, 24(02), 043-048
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Table 2 Equipmen Used
S . No.
Name o Equipmen
1
Fou ie T ans o m In a ed Spec opho ome e
(IR. The moscien i ic Nicole is 10)
2
UV/Vis Spec opho ome e s
No : Qc. cp-057 (u jasco 2016)
3
pH Me e
H12216 pH/ ORP/ISE Me e
4
Ul a-sonic
5
Elec onic Balance
Sa o ius No: Oc-Cp.059
6
Ha dness Tes e
Rimek- India. No: cp.010.
7
Disin eg a ion Tes e
(disin eg a ion es e -bj-3)
8
HPIC 2020
9
Dissolu ion Tes e
(Rc-80C) No: Qc-cp-071
10
Table Machine
Ro a y able s p ess machine Zp-7
11
F iabili y Tes e
(Cjy-300D Table s iabili y es e )
12
Thickness Tes e : Ve nie calipe (S ainless ha dened)
13
O en Incuba o (Accele a e S abili y S udy Chambe )
2.2. Me hod o P epa a ion (We g anula ion)
2.2.1. Weighing and Mixing
Accu a ely weigh he equi ed quan i ies o :
• Albendazole (API)
• S a ch (as diluen and binde )
• Dex ose (as swee ene and ille )
• Suc ose (as swee ening and bulking agen )
• Calcium Ca bona e (as ille and an acid)
• Sodium Bica bona e (as disin eg an )
• Vanillin (as la ou ing agen )
• T ans e all he weighed powde s o a clean, d y mo a .
• Mix ho oughly o 10–15 minu es o ob ain a uni o m powde blend.
2.2.2. P epa a ion o Binde Solu ion
P epa e a 5% w/ gela in solu ion:
• Dissol e 5 g o gela in in 100 mL o wa m wa e wi h gen le s i ing un il a clea solu ion o ms.
• Allow he binde solu ion o cool o oom empe a u e be o e use.
Wo ld Jou nal o Biology Pha macy and Heal h Sciences, 2025, 24(02), 043-048
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2.2.3. We G anula ion
• G adually add he p epa ed gela in binde solu ion o he blended powde mix u e.
• Mix ho oughly and knead he mass un il a damp, cohesi e mass is ob ained sui able o g anula ion.
2.2.4. Sie ing o We Mass
Pass he mois mass h ough a #16 mesh sie e o o m uni o m we g anules.
2.2.5. D ying
• Sp ead he we g anules e enly on ays.
• D y in a ho ai o en a 40–45°C un il he mois u e con en alls below 2%.
• (D ying ime: app oxima ely 30–45 minu es, depending on ba ch size.)
2.2.6. Sizing / Si ing
Pass he d ied g anules h ough a #20 mesh sie e o emo e lumps and achie e uni o m g anule size.
2.2.7. Lub ica ion
• Add Talc (as glidan and lub ican ) o he d ied g anules
• Blend gen ly in a double-cone blende o mo a o abou 5 minu es o ensu e uni o m dis ibu ion wi hou
o e -lub ica ion.
2.2.8. Comp ession
• Comp ess he inal lub ica ed g anules in o able s using a single-punch o o a y able p ess i ed wi h la -
aced punches.
• Adjus comp ession p essu e o achie e able s o uni o m ha dness and weigh .
2.2.9. Fo mula ion And E alua ion o Albendazole
Table 3 Fo mula ion Table
Ing edien in mg
F1
F2
F3
F4
F5
Albendazole
246.2
246.2
246.2
246.2
246.2
S a ch
6.2
4.1
_
4.1
4.1
Dex ose
6.2
9.2
6.2
_
6.2
Gela in
3.1
3.1
6.2
3.1
_
Suc ose
6.2
_
6.2
3.1
6.2
Sodium Bica bona e
3.1
3.1
3.1
3.1
3.1
Talc
1.2
1.2
1.2
1.2
1.2
Vanillin
1.2
1.2
1.2
1.2
1.2
Calcium Ca bona e
0.6
0.6
0.6
0.6
0.6
To al weigh
400
400
400
400
400
2.3. E alua ion o Albendazole
2.3.1. Weigh Va ia ion
To con i m uni o mi y in d ug con en , wen y able s we e andomly selec ed om each ba ch (F1–F5) and weighed
indi idually. The a e age weigh o a single able was calcula ed, and de ia ions o indi idual able s om his mean
we e assessed o ensu e compliance wi h pha macopeial s anda ds.
Wo ld Jou nal o Biology Pha macy and Heal h Sciences, 2025, 24(02), 043-048
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2.3.2. Table Diame e
The uni o mi y in able size was examined by measu ing he diame e o i e andomly chosen able s om each ba ch
using a mic ome e . The mean diame e o each o mula ion was de e mined o e alua e size consis ency.
2.3.3. Table Thickness
Table hickness was measu ed using an elec onic Ve nie calipe on i e andomly selec ed able s om each ba ch.
The a e age hickness o he able s was eco ded in millime e s, p o iding in o ma ion on dimensional uni o mi y.
2.3.4. Ha dness
The c ushing s eng h o he able s, which indica es mechanical s abili y, was measu ed using a digi al ha dness es e .
Fi e able s om each ba ch we e es ed, and he mean ha dness, exp essed in kg/cm², along wi h s anda d de ia ion,
was calcula ed o de e mine he able s’ esis ance o mechanical s ess du ing handling.
2.3.5. F iabili y
F iabili y es ing was pe o med o assess he able s’ abili y o wi hs and ab asion. A p e-weighed sample o i e able s
om each ba ch was placed in a Roche iabila o and o a ed 100 imes. The able s we e hen weighed again, and he
pe cen age weigh loss was calcula ed. Table s wi h a weigh loss o less han 1% we e conside ed accep able.
2.3.6. In- i o Disin eg a ion
The disin eg a ion es was conduc ed o e alua e he ime equi ed o able s o b eak down unde s anda d
labo a o y condi ions. Six able s om each ba ch we e placed indi idually in a disin eg a ion appa a us con aining
dis illed wa e main ained a 37 ± 0.5 °C. The ime aken o comple e disin eg a ion, lea ing no esidue, was eco ded,
and he a e age disin eg a ion ime o each ba ch was calcula ed.
3. Resul and discussion
Table 4 E alua ion pa ame e s o Albendazole
Fo mula ion Code
Ha dness
Thickness
F iabili y%
A e age Weigh
D ug Con en
F1
3.15 ± 0.08
2.78
0.29
405.3
246.2 ± 1.0
F2
3.25 ± 0.07
2.84
0.25
414.7
246.2 ± 1.1
F3
3.11 ± 0.08
2.80
0.31
429.5
246.2 ± 1.2
F4
3.20 ± 0.06
2.85
0.27
438.8
246.2 ± 1.1
F5
3.13 ± 0.05
2.79
0.28
449.2
246.2 ± 1.2
4. Conclusion
The e alua ion o he i e Albendazole 400 mg able o mula ions (F1–F5) demons a ed ha all ba ches exhibi ed
sa is ac o y mechanical s eng h, uni o mi y, and d ug con en , wi h ha dness alues anging om 3.11 o 3.25 kg/cm²,
iabili y be ween 0.25 and 0.31 %, and consis en d ug con en a ound 246 mg. Va ia ions in excipien composi ion,
including s a ch, dex ose, gela in, and suc ose, sligh ly a ec ed able weigh and ha dness, ye all o mula ions
main ained accep able physical and quali y a ibu es. These indings align wi h p io esea ch on Albendazole able
de elopmen , highligh ing ha ca e ul selec ion o excipien s combined wi h op imized we g anula ion echniques can
yield able s wi h uni o m con en , s abili y, and po en ial he apeu ic e icacy. Mino di e ences in able weigh
indica e scope o u he op imiza ion o enhance dosing p ecision, bu o e all, he o mula ions ep esen a p omising
app oach o he e ec i e o al deli e y o Albendazole.
Wo ld Jou nal o Biology Pha macy and Heal h Sciences, 2025, 24(02), 043-048
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Compliance wi h e hical s anda ds
Acknowledgmen s
I since ely acknowledge he con inuous guidance, encou agemen , and cons uc i e eedback p o ided by my men o ,
Ms. Reema Chand akan Londhe. He expe ise, pa ience, and suppo ha e been in aluable in shaping his e iew
pape . I also ex end my g a i ude o Sama h Ins i u e o Pha macy, Belhe, o p o iding he necessa y academic
en i onmen , acili ies, and esou ces ha enabled he success ul comple ion o his wo k.
Disclosu e o con lic o in e es
No con lic -o -in e es o be disclosed.
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