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Towards a Pre-diagnose of Surgical Wounds through the Analysis of Visual 3D Reconstructions

Abstract

This paper presents a new methodology to pre-diagnose the state of post-surgical abdominal wounds based on visual information. The process consist of four major phases: a) building dense 3D reconstruction of the abdominal area around the wound, b) selecting an area close to the wound to fit a plane, c) calculating the distance from each point of the 3D model to the plane, d) analyzing this map of distances to infer if the wound is inflamed or not. This method needs to be wrapped in an application to be used by patients in order to save unnecessary visits to the medical center.

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Towards a Pre-diagnose of Surgical Wounds through the Analysis of Visual 3D Reconstructions

Author: Muntaner Estarellas, Neus; Bonin Font, Francisco; Segura Sampedro, Juan José; Jiménez Ramírez, Andrés; Negre Carrasco, Pep L.; Massot Campos, Miquel; González Argenté, Francesc X.; Oliver Codina, Gabriel
Publisher: SciTePress
Year: 2018
DOI: 10.5220/0006628505890595
Source: https://idus.us.es/bitstreams/9027c0a0-e7b2-4a7b-a2a6-51eb2a07cd6c/download
Towa ds a P e-diagnose o Su gical Wounds h ough he Analysis o
Visual 3D Recons uc ions
Neus Mun ane Es a ellas3, F ancisco Bonin-Fon 1, Juan J. Segu a-Samped o2,
And es Jim´
enez Ram´
ı ez3, Pep L. Neg e Ca asco1, Miquel Masso Campos1,
F ancesc X. Gonzalez-A gen ´
e2and Gab iel Oli e Codina1
1Depa men o Ma hema ics and Compu e Enginee ing, Uni e si y o he Balea ic Islands,
C a. Valldemossa Km 7.5, 07122 Palma de Mallo ca, Spain
2Depa men o Gene al and Diges i e Su ge y, Uni e si y Hospi al Son Espases,
07122 Palma de Mallo ca, Spain
3G oup o Ingenie ´
ıa Web y Tes ing Temp ano, Depa men o Languages and Compu ing Sys ems, Uni e si y o Se illa,
c/ San Fe nando 4, 41004 Se illa, Spain
Keywo ds: 3D Visual Recons uc ion, S uc u e F om Mo ion, Pos -su gical Wound, Telemedicine.
Abs ac : This pape p esen s a new me hodology o p e-diagnose he s a e o pos -su gical abdominal wounds based
on isual in o ma ion. The p ocess consis o ou majo phases: a) building dense 3D econs uc ion o he
abdominal a ea a ound he wound, b) selec ing an a ea close o he wound o i a plane, c) calcula ing he
dis ance om each poin o he 3D model o he plane, d) analyzing his map o dis ances o in e i he wound
is in lamed o no . This me hod needs o be w apped in an applica ion o be used by pa ien s in o de o sa e
unnecessa y isi s o he medical cen e .
1 INTRODUCTION
The eme gency and he ou pa ien acili ies o he
Spanish public heal h ca e sys em a e usually col-
lapsed by he nume ous o unnecessa y isi s o he
assis ance cen e s ha could be sol ed a home wi h
se e al indica ions gi en by he co esponding spe-
cialis .
In 2017, mo e han 3000 ope a ions we e done
in he Uni e si y Hospi al Son Espases, in Palma de
Mallo ca, om which, only app oxima ely he hal o
hem we e p og ammed. Tha makes a mean o 250
pa ien s pe mon h, 63 pa ien s pe week, and 13 pa-
ien s pe day. I he consul mean ime in Spain is
in ended o ange be ween 6 and 10 minu es, i makes
a mean o 2 hou s a day dedica ed only o ake ca e
o pos su ge y wounds, wi hou aking in o consid-
e a ion he es s o asks, such as, new pa ien s, non
su ge y pa ien s, managemen mee ings o eme gen-
cies.
E e y su ge y pa ien is e alua ed wice a e he
su gical p ocedu e. The i s e iew is a he heal h
cen e a e a week. And i is e alua ed again one
mon h la e as ou pa ien , a he hospi al. One o he
main easons o his e alua ion is o check he su gi-
cal wound and de ec i s in ec ion. Howe e he a e
o in ec ion is low and when i happens i is usually
de ec ed in he eme gency depa men .
This ace- o- ace consul a ions, whe e mos o
hem p esen no anomalies, could be easily managed
emo ely, ha ing a cheape cos and a ec ing less
he pa ien s’ quali y o li e, as hey equi e unneces-
sa y ans e s o he heal h acili y and absences om
wo k. Mo eo e , i he pa ien is unable o suspec
he wound in ec ion on ime, as i usually happens, an
inc ease o he eme gency depa men consul a ions
is p oduced, no mally wi h a delay in he wound in-
ec ion diagnosis which esul s in an inc ease o isi
ime pe pa ien .
Consequen ly, e e y echnological p og ess in he
ield o heal h ca e managemen , in gene al, and in he
pos -su ge y assis ance in pa icula , is e y use ul o
educe he cos s, o imp o e he quali y o assis ance
ime and hus o inc ease he quali y o li e o he
pa ien s. Medical compu e and mobile applica ions
ocused on emo e au oma ic diagnose and pa ien
managemen /moni o ing ha e been ad ancing in he
las yea s ci eneph o low, (Topdoc o s, 2017). La ely,
some s udies in elemedicine suppo he easibili y
and sa e y o emo e ollow-up in su gical wounds
Es a ellas, N., Bonin-Fon , F., Segu a-Samped o, J., Ramí ez, A., Ca asco, P., Campos, M., Gonzalez-A gen é, F. and Codina, G.
Towa ds a P e-diagnose o Su gical Wounds h ough he Analysis o Visual 3D Recons uc ions.
DOI: 10.5220/0006628505890595
In P oceedings o he 13 h In e na ional Join Con e ence on Compu e Vision, Imaging and Compu e G aphics Theo y and Applica ions (VISIGRAPP 2018) - Volume 4: VISAPP, pages
589-595
ISBN: 978-989-758-290-5
Copy igh ©2018 by SCITEPRESS – Science and Technology Publica ions, Lda. All igh s ese ed
589
and he pa ien s sa is ac ion (Segu a-Samped o e al.,
2017). In his la e e e ence as well as in simila
s udies (No dheim e al., 2014), pho os o ideos o
he wound and illed ques ionnai es cons i u e he ex-
changed da a be ween he pa ien and he doc o , bu
is he doc o who always analyzes and e alua es he
ecei ed in o ma ion. Howe e , o ou knowledge,
none o he e ised me hods o Apps is able o es i-
ma e, au oma ically, a eliable p e-diagnose based on
isual da a, and o il e ou hose wounds ha clea ly
p esen a good e olu ion, wi hou he in e en ion o
he physician. Following his line, he Depa men o
Gene al and Diges i e Su ge y o he Uni e si y Hos-
pi al Son Espases is collabo a ing wi h he Sys ems,
Robo ics and Vision g oup o he Uni e si y o he
Balea ic Islands, in o de o go one s ep o wa d in he
design and implemen a ion o a ision-based mobile
App o elemedicine ha can help in he es ima ion
o a p e-diagnose o abdominal pos su ge y wounds.
The objec i e is il e ing, au oma ically, hose wounds
ha po en ially p esen in lamma ion as sign o in ec-
ion and need a ace- o- ace e alua ion in he hospi al
om hose ha cou se a no mal e olu ion and can be
managed a home, sa ing ime and medical esou ces.
The no el y o his wo k is mo e in he me hodology
i sel and he applica ion han in he pipeline o isual
algo i hms designed o ge he objec i e. This me hod
needs o be w apped in o a u u e compac mobile
App, which will con ain addi ional unc ionali ies o
inc ease he communica ion and da a exchange be-
ween doc o s and pa ien s.
The wound analysis p ocess consis s o a pipeline
ha in ol es he nex s eps: a) g ab a ideo sequence,
wi h he mobile, o he abdominal zone a ound he
wound, om side o side, iewing he same a ea bu
om di e en pe spec i es and iewpoin s, b) ex ac
images o he ideo sequence, c) ex ac and ack
common isual ea u es in all he images, d) build a
3D spa se poin cloud using a S uc u e F om Mo ion
(SFM) (Ha ley and Zisse man, 2003) algo i hm, e)
build a dense poin -cloud and a ex u ed meshed su -
ace, ) es ablish a polyline and a plane i ed in his
polyline in a selec ed po ion o he 3D model; his
plane is in ended o be, ei he angen o he abdomen
su ace, o c ossing he abdominal a ea, below he
wound, g) compu e he dis ance be ween each poin
o he 3D model and he plane, and emi a diagnose
unc ion o hese dis ances.
2 METHODOLOGY
Fi s ly, he pa ien mus eco d wi h he mobile ele-
phone a ideo o he wound, om side o side o he
abdominal a ea, in o de o ha e iews om di e en
pe spec i es and iewpoin s. The second s ep is au-
oma ic and consis o ex ac ing all he images om
he ideo sequence. Once he images ha e been ex-
ac ed, he p ocess o 3D econs uc ion s a s au o-
ma ically wi h he ea u e acking p ocess. The SFM
geome ic heo y (Ha ley and Zisse man, 2003) is
based on he acking o a se o wo ld poin s p o-
jec ed in se e al images aken by he same came a
om di e en iewpoin s. These p ojec ed poin s
and hei co espondences in he subsequen images
a e ob ained hanks o a p ocess o a classical isual
ea u e de ec ion and ma ching (Ha ley and Zisse -
man, 2003) using wo epu ed de ec o s in a ian o
o a ion and scale: one de ec o wi h scala desc ip-
o , SIFT (Lowe, 2004), and one de ec o wi h bina y
desc ip o s, ORB (Rublee e al., 2011). Bo h ech-
niques ha e p o ed ex endedly his excellen pe o -
mance in e ms o numbe o ea u es, obus ness and
aceabili y. In a iance o scale and o a ion is impo -
an o his kind o applica ion since he image key
poin s mus be iden i ied in all ames o he ideo se-
quence, which show he a ec ed a ea om di e en
iewpoin s. Figu e 1 shows an image p o ided by he
Uni e si y Hospi al Son Espases o a su gical wound,
wi h he isual ea u es ob ained using he 2 di e en
de ec o s.
(a) (b)
Figu e 1: Fea u e de ec ion wi h: (a) SIFT, (b) ORB.
The ea u e de ec ion wi h he 2 es ed ea u es has
been implemen ed wi h he ea u e de ec o OpenC 2
unc ions. The desc ip o ma ching has been imple-
men ed wi h he FLANN (Muja and Lowe, 2009)
ma che lib a y. Good ma ches (inlie s) a e consid-
e ed o be hose which dis ance be ween co espon-
dences in di e en images is unde a ce ain h eshold
( ypically, ei he 0.02 o 2 imes he minimum dis-
ance be ween all he ma ches). Bad ma ches a e dis-
ca ded.
Gi en he p ojec ion ma ices, he 3D coo dina es
o a wo ld poin can be ob ained om i s co espond-
ing image poin s (in his case isual ea u es) iden i-
ied in se e al iews (ma ching) using iangula ion.
Ideally, he 3D poin should lie in he in e sec ion o
all back-p ojec ed ays. Bu , in gene al, hese ays
will no in e sec in a single poin due o he e o s in-
he en o he ea u e ma ching p ocess. The 3D coo -
dina es o he wo ld poin a e ob ained minimizing he
VISAPP 2018 - In e na ional Con e ence on Compu e Vision Theo y and Applica ions
590
sum o squa ed e o s be ween he measu ed and he
p edic ed image posi ions o he 3D poin p ojec ed
in all in ol ed iews whe e he wo ld poin is isible:
X=a gminx∑ikui−ˆuik2, whe e uiis he p edic ed
image poin and ˆuiis he co esponding measu ed im-
age poin , o all he iimages whe e he 3D poin is
p ojec ed. The p edic ed image poin can be ob ained,
o example, om he ea u e ma ching p ocess, and
he measu ed poin is di ec ly he p ojec ion o he
wo ld poin on he image.
The lib a y OpenMVG (Moulon e al., 2017) im-
plemen s he poin iangula ion and he 3D eco -
e y applying he SFM and he epipola heo ies, e-
co e ing also he came a displacemen , and has been
used o o m spa se 3D poin -clouds om inpu se s
o images. OpenMVS (cDcSeaca e, 2017) p o ided
us wi h a comple e se o algo i hms o eco e a ull,
ine and ex u ed su ace om a se o came a poses
and a spa se poin -cloud.
Figu e 2 illus a es he image p ocessing pipeline
designed and implemen ed o ob ain a dense 3D
model o he eco ded a ea. The ou i s s eps ha e
been p og ammed wi h OpenMVG, and he las ou
s eps wi h OpenMVS. The SFM implemen a ion is
based on (Moulon e al., 2013). This p ocess is inc e-
men al, which means ha , he i s econs uc ion is
done only wi h wo iews, and a e e y i e a ion a new
iew is inco po a ed adding ea u es, some ma ch-
ing wi h he p e ious and needing iangula ion, some
new in he scene. The econs uc ion wi h known
poses e e s o he p ocess o e ining he 3D model
using he came a poses and he 3D poin posi ion el-
a i e o he know came a poses, once he SFM and
he came a mo ion ha e been compu ed. The poin
cloud densi ica ion is based on (Ba nes e al., 2009),
he mesh econs uc ion is based on (Jancosek and
Pajdla, 2014), he mesh e inemen is based on (Vu
e al., 2012), and inally, he mesh ex u ing is based
on (Waech e e al., 2014).
Figu e 2: Image p ocessing pipeline o wound 3D econ-
s uc ion.
A 3D econs uc ion o an abdominal a ea wi h
a pos su gical wound is p esen ed in igu e 3 as
(a) (b)
(c) (d)
Figu e 3: A esul o he 3D econs uc ion pipeline: (a) a
ame o he eco ded ideo, (b) he dense poin cloud, (c)
e ined mesh, (d) e ined and ex u ed mesh.
a sample o he pipeline pe o mance. 130 ames
we e ex ac ed om he ideo. One sample image is
shown in igu e 3-(a) and he ideo can be seen in
h ps://you u.be/XW18WMFZPTw. The appea ance
o he econs uc ed abdomen is highly ealis ic, bu
wi hou a me ic scale i is impossible o in e he 3D
s uc u e dimensions.
Figu e 4: Templa e used o scale he ob ained 3D model.
The ob ained 3D model has no me ical uni s,
since i is compu ed om he images and he i-
sual ea u e coo dina es which a e exp essed in pix-
els. Con e ing hese da a in o me ical da a was nec-
essa y o es ima e he wound s a e om he 3D e-
cons uc ion. To his end, he geome ic empla e o
igu e 4 was designed. This empla e con ains one
colo calib a ion pa e n, no ye used in his wo k,
one geome ical ma ke which side measu es 3.1cm
and a ec angula hole in be ween. The empla e mus
be placed on he abdomen wi h he wound alling
jus inside he ec angula hole. Once he empla e
is co ec ly placed, he ideo can be eco ded. The
scale a io applicable o all econs uc ed 3D poin s
can be calcula ed di iding he ma ke side eal me ic
Towa ds a P e-diagnose o Su gical Wounds h ough he Analysis o Visual 3D Recons uc ions
591
by i s leng h measu ed in he 3D model. A sample
o a ideo eco ded wi h he empla e can be seen a
h ps://you u.be/IN kQlNXbu0.
In o de o pe o m he las s eps o he pipeline
which include he plane i ing and he dis ance calcu-
la ion, he esul ing 3D poin cloud was opened wi h
Cloud Compa e (Gi a deau-Mon au , 2017). Using
his applica ion, he 3D olume was c opped a ound
he wound and scaled acco ding o he measu es p o-
ided by he ma ke o he empla e (i i was a ail-
able). A e wa ds, a polyline was c ea ed inside he
p ocessed 3D olume o i a plane inside i . This
plane was in ended o be, ei he coinciden wi h he
plane o he ma ke , o pa allel o i , angen o he
abdomen su ace, jus a he wound base, o cu ing
he abdomen su ace in ou poin s, below he wound.
Finally, he dis ance o each poin o he cloud o he
i ed plane was calcula ed and expo ed o a cs ile.
The analysis o hese dis ances o each case leads o
an a emp o es ima ed diagnose.
3 EXPERIMENTS
In o de o e alua e he comple e p ocedu e, some
simula ed expe imen s we e ini ially pe o med using
he empla e and a small cable wi h a diame e o 4mm
simula ing an in lamed wound. Figu e 5-(a) shows an
image o one simula ed scene.
(a) (b)
Figu e 5: Simula ed wound: (a) an image o he simula ed
scene, (b) he ex u ed mesh.
The leng h o he ma ke side in he 3D econ-
s uc ion, measu ed in Cloud Compa e was 0.122898
uni s. Knowing ha he eal leng h o he ma ke side
is 3.1cm, he scale ac o se in Cloud Compa e o
he 3 di ec ions (x, y, z) was 0.031(m)/0.122898 =
0.25224169m. In his case, he i ed plane was co-
inciden wi h he plane o he ma ke . Figu e 5-(b)
shows he ex u ed mesh.
Figu e 6 shows he selec ed olume in yellow (a),
he same olume wi h he i ed plane (bo de in whi e
and plane a ea in blue) in (b), and he spa ial map
o dis ances be ween all poin s o he selec ed ol-
ume and he i ed plane, in (c). No ice how he pos-
i i e (yellow-o ange) dis ances ange be ween 2mm
and 4mm, along he ec angle, clea ly di e en ia ing
he cable p o ile om he su ounding a ea (blue). Ly-
ing he i ed plane on he empla e, hese posi i e dis-
ances coincide app oxima ely wi h he cable diame-
e .
Figu e 7-(a) shows an image o ano he in lamed
wound simula ed wi h a small cable. Figu es 7-(b), 7-
(c) and 7-(d) show, espec i ely, he e ined and ex-
u ed mesh, he selec ed olume in yellow wi h he
polyline i ing plane in whi e and he map o dis-
ances om poin s o he plane. The scale ac o e-
sul ed in 0.031m/0.0611679 =0.50680177m, being
0.0611679 he ma ke side leng h measu ed in Cloud
Compa e. The map o dis ances shows clea ly he
linea shape o he simula ed in lamed wound in he
cen e o he ec angle wi h posi i e dis ances a ound
3mm su ounded by poin s ha ma k nega i e dis-
ances below −4mm.
Figu e 8-(a) shows he selec ed olume in yellow
a ound he wound o igu e 3 wi h he polyline i ing
he plane in whi e. In his case, he plane in e sec s he
abdomen below he wound, in one pa , and abo e,
in ano he . This is a case o a wound wi h a good
e olu ion, wi hou in lamma ion. Figu e 8-(b) shows
he co esponding map o dis ances o he i ed plane.
The cen al a ea in yellow indica es whe e he plane
is below he wound and he dis ance is bigge while
he ex emes which end o blue indica e whe e he
dis ance is smalle . In his case, he me ic uni s and
alues ha e no ele ance. Since he e a e no poin s
in he cen e o he map ha ma k he shape o he
wound, one can conclude ha mos likely he e is no
in lamma ion on he explo ed a ea.
Figu e 9-(a) shows an image ex ac ed om a
ideo o ano he example o pos su gical wound wi h
a good e olu ion and no in lamma ion. In his case
he scale is also i ele an . 35 images we e ex ac ed
o build he e ined and ex u ed 3D model, shown
in igu e 9-(b). In his expe imen , he plane was
i ed below he abdomen as shown in whi e in ig-
u e 9-(c). The map o dis ances is show in igu e 9-
(d). The la e shows clea ly he di e ence be ween
he cen al a ea wi h posi i e dis ances co esponding
o he zone wi h maximum cu a u e o he abdomen
(maximum dis ance o he plane), and bo h sides ( op
and bo om) whe e he dis ance be ween he plane and
he abdomen is minimum, wi hou any pa sugges -
ing he p esence o any in lamed a ea in he o m o
a ans e sal line o dis ances clea ly abo e he es .
These ype o esul ing plo would sugges o he pa-
ien and o he doc o , in p inciple, an unnecessa y
ace- o- ace e ision.
Figu e 10-(a) shows an image ex ac ed om
VISAPP 2018 - In e na ional Con e ence on Compu e Vision Theo y and Applica ions
592
(a) (b) (c)
Figu e 6: Simula ed wound: (a) he selec ed olume and he polyline a ound i depic ed in yellow, (b) he polyline in yellow
and he i ed plane in whi e, (c) map o dis ances om each poin o he i ed plane.
(a) (b)
(c) (d)
Figu e 7: Expe imen 2: (a) an image ex ac ed om he
ideo sequence, (b) e ined and ex u ed mesh, (c) he
wound wi h he i ed plane depic ed in whi e, (d) Map o
dis ances om each poin o he i ed plane.
(a) (b)
Figu e 8: Expe imen 3: wound o igu e 3: (a) he wound
wi h he polyline and he i ed plane, (b) Map o dis ances
om each poin o he i ed plane.
ano he expe imen on a eal pos -su gical wound
g abbed wi h he empla e. In his case, he wound
p esen s an e iden in lamma ion o se e al milime-
e s. 17 images we e ex ac ed om he ideo o
build he 3D model. The scaling ac o u ned ou
(a) (b)
(c) (d)
Figu e 9: Expe imen 4: (a) an image ex ac ed om he
ideo sequence, (b) e ined and ex u ed mesh, (c) he
wound wi h he i ed plane, (d) Map o dis ances om each
poin o he i ed plane.
o be 0.359min all di ec ions. Figu es 10-(b), 10-
(c) and 10-(d) show, espec i ely, he e ined ex u ed
mesh, he 3D model wi h he polyline in whi e i -
ing he plane, coinciden wi h he empla e cen al
hole, and he co esponding g aphic o dis ances. The
la e shows how he poin s loca ed in he bo de s o
he ec angle p esen dis ances be ween −5mm and
−10mm, while in he middle, especially in he uppe
pa which coincides wi h he side o he wound ha
has he ma ke a i s le and i is clea ly below he
plane, poin dis ances ange be ween 0mm and 5mm.
Al hough he e is a clea g adien o dis ances be-
ween some pa s o he cen e and he sides o he
e alua ed a ea, suscep ible o being p e-diagnosed as
in lamed, he shape o he wound is no clea ly iden-
i ied, being necessa y a inal and de ini i e diagnose
gi en by he doc o .
Towa ds a P e-diagnose o Su gical Wounds h ough he Analysis o Visual 3D Recons uc ions
593

(a) (b)
(c) (d)
Figu e 10: Expe imen 5: (a) an image ex ac ed om
he ideo sequence, (b) e ined and ex u ed mesh, (c) he
wound wi h he i ed plane, (d) map o dis ances om each
poin o he i ed plane.
Finally, igu e 11-(a) shows one ame o a wound
which was opened due o an in e nal in ec ion. Fig-
u e 11-(b), igu e 11-(c) and igu e 11-(d) show, e-
spec i ely, he e ined and colo ed mesh, he 3D a ea
wi h he polyline i ing he plane, in whi e, and he
map o dis ances. The empla e was pu jus on he
skin, and he plane was i ed a ound he hole. The
dis ance map e idences a blue zone in he middle co -
esponding o he opened wound wi h dis ances be-
low he plane a ound 3mm (−3mm), su ounded by
a o ange a ea wi h dis ances be ween 1mm and 4mm
abo e he plane co esponding o he skin. This g adi-
en o dis ances ma ks clea ly an anomaly in he a ea.
The posi ion in which he empla e is placed on
he wound, i s adjus men o he abdomen, and he
way he plane i i ed in he selec ed olume a ec s
clea ly he ob ained esul s. The p ocedu e needs o
be e ined, bu he ini ial esul s a e clea ly encou ag-
ing.
4 CONCLUSIONS
This pape has p esen ed an inno a i e me hodology
o es ima e a p e ious diagnose o pos -su gical ab-
dominal wounds using isual da a. Al hough expe i-
men s wi h simula ed scenes e eal a clea di e ence
be ween he simula ed in ec ed wound and he back-
g ound, esul s o expe imen s wi h eal wounds a e
s ill on a p elimina y s age, bu poin ing in a clea
good di ec ion. Now he challenge lies, mainly, in
(a) (b)
(c) (d)
Figu e 11: Expe imen 6: (a) an image om he ideo se-
quence, (b) e ined and ex u ed mesh, (c) he wound wi h
he i ed plane, (d) map o dis ances.
wo di e en issues: a) e ine he cu en p ocess o
ge clea e esul s, basically es ing se e al possibili-
ies in he posi ioning o he empla e and in he gen-
e a ion o he i ed plane, and b) in eg a ing his me-
hodology in a so wa e package, which au oma izes
all he s ages o he p ocess un manually wi h Cloud
Compa e o be in eg a ed in a use s applica ion.
ACKNOWLEDGEMENTS
This wo k is pa ially suppo ed by Minis y o
Economy and Compe i i eness unde con ac s
TIN2014-58662-R, DPI2014-57746-C3-2-R and
FEDER unds.
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