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Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention

Medina-Torres, Miguel Ángel,Ocaña Farfán, María del Carmen,Martínez-Póveda, Beatriz Amparo,Carrillo Fernández, Paloma,Urdiales-Ruiz, José Luis,Serrano, José J.,Montañez, Raúl,Rodríguez-Quesada, Ana María · 2017

Abstract

The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the hallmarks of cancer. However, cancers grow in tight contact with non-tumoral accompanying cells and the surrounding extracellular matrix, as underlined by the concept of tumor microenvironment. Endothelial cells are key components of this tumor microenvironment, since they are requested for angiogenesis, another hallmark of cancer. In this complex system, rewiring of metabolism and signaling pathway in cancer, endothelial and other accompanying cell emerges as new potential targets for therapeutic intervention. In this communication, we will present the drug discovery and characterization approach of our group and our more recent results in this field, including new modeling with an evolutionary and ecological point of view.

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Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention

Author: Medina-Torres, Miguel Ángel,Ocaña Farfán, María del Carmen,Martínez-Póveda, Beatriz Amparo,Carrillo Fernández, Paloma,Urdiales-Ruiz, José Luis,Serrano, José J.,Montañez, Raúl,Rodríguez-Quesada, Ana María
Year: 2017
Source: https://riuma.uma.es/xmlui/bitstream/10630/14404/1/03-Preview%20Abstract.pdf
24/7/17 12'30
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FEBS3+ Ba celona 2017
The 1s FEBS3+ Join Mee ing o he F ench-Po uguese-Spanish Biochemical and Molecula Biology Socie ies
Ba celona, Oc obe 23-26, 2017
P18-20
E alua ion o me abolism and biosignaling in he angiogenic mic oen i onmen as po en ial a ge s o
he apeu ic in e en ion
Miguel Ángel Medina1, Mª Ca men Ocaña2, Bea iz Ma ínez-Po eda2, Paloma Ca illo2, José Luis
U diales1, José J. Se ano2, Raúl Mon añez1, Ana R. Quesada1
11) Uni e sidad de Málaga, Andalucía Tech, Depa amen o de Biología Molecula y Bioquímica,
Facul ad de Ciencias e IBIMA (ins i u o de Biomedicina de Málaga), Málaga, ES 2) Unidad 741, CIBER
de En e medades Ra as (CIBERER). , Málaga, ES, 2Uni e sidad de Málaga, Andalucía Tech,
Depa amen o de Biología Molecula y Bioquímica, Facul ad de Ciencias e IBIMA (ins i u o de
Biomedicina de Málaga), Málaga, ES, Málaga, ES
The " e-disco e y" o Wa bu g e ec a he u n o he p esen millennium has been a key de e minan o
he cu en enewed in e es on cance me abolism. In ac , me abolic ep og amming has been iden i ied
as one o he hallma ks o cance . Howe e , cance s g ow in igh con ac wi h non- umo al
accompanying cells and he su ounding ex acellula ma ix, as unde lined by he concep o umo
mic oen i onmen . Endo helial cells a e key componen s o his umo mic oen i onmen , since hey a e
eques ed o angiogenesis, ano he hallma k o cance . In his complex sys em, ewi ing o me abolism
and signaling pa hway in cance , endo helial and o he accompanying cell eme ges as new po en ial
a ge s o he apeu ic in e en ion. In his communica ion, we will p esen he d ug disco e y and
cha ac e iza ion app oach o ou g oup and ou mo e ecen esul s in his ield, including new modeling
wi h an e olu iona y and ecological poin o iew. [Ou expe imen al wo k is suppo ed by g an s
BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Go e nmen and FEDER)
and unds om g oup BIO-267 (Andalusian Go e nmen ). The "CIBER de En e medades Ra as" is an
ini ia i e om he ISCIII (Spain)]. This communica ion has he suppo o a a el g an "Uni e sidad de
Málaga. Campus de Excelencia In e nacional Andalucía Tech".