71
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
DETERMINATION OF TECHNOLOGICAL PROPERTIES OF MADDER EXTRACT
Rakhimo a G.R.1
Zha lie a U.2
Tashken Pha maceu ical Ins i u e, Tashken ci y, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17318743
Rele ance: U oli hiasis (u oli hiasis) is a polye iologic, polypa hognomonic me abolic
diso de cha ac e ized by he o ma ion o kidney s ones. U oli hiasis is common a any age, mos
o en be ween 20 and 50 yea s. U oli hiasis accoun s o 30-40% o he easons o hospi aliza ion in
u ology depa men s o hospi als . Acco ding o he Wo ld Heal h O ganiza ion Acco ding o he
Wo ld Heal h O ganiza ion (WHO), he bal medicines cons i u e a signi ican po ion o p oduc ion
olume. Madde is widely used in Uzbekis an, he Russian Fede a ion, India and China. Rhizomes
and oo s o madde as he dominan g oup subs ances con ain an h aquinones, which help p e en
s one o ma ion in he kidneys, hei des uc ion in he kidneys, and also emo e oxalic, phospha e
and o he sal s.
The pu pose o he s udy. The pu pose o he scien i ic esea ch is o de e mine he
echnological p ope ies o madde ex ac . ( Rubia inc o um L.) .
Ma e ials and me hods: G anulome ic ( ac ional) composi ion. The de e mina ion was
ca ied ou by si ing 100.0 g o he subs ance h ough a sie e se consis ing o 5 sie es wi h a mesh
diame e o 2 mm, 1 mm, 0.5; 0.35 mm and 0.25 mm. The se was he me ically sealed wi h a casing.
The sample was si ed on a ib a ing ins alla ion wi h a numbe o oscilla ions o 340-360/min o 5
min. The ope a ion was epea ed 3 imes and he a e age alues o he mass o he subs ance ha
passed h ough a sie e o a ce ain diame e we e calcula ed. Pa icle shape and size. The shape and
size o he pa icles we e de e mined on an op ical mic oscope, wi h a magni ica ion ange om 4 o
64 imes. Angle o epose. The angle o epose was de e mined on a special de ice "Measu ing
equipmen o he angle o epose DF-1-05", co esponding o he na ional s anda d o he People's
Republic o China GB / T16913-2008. The measu ing ins umen 's unnel is made o s ainless s eel
wi h a 5 mm diame e opening. Measu emen s we e pe o med in iplica e (acco ding o he
p ocedu e desc ibed in OFS.1.4.2.0016.15 "Deg ee o Powde Flowabili y" o he S a e
Pha macopoeia, 14 h edi ion) using a p o ac o in h ee planes and exp essed as angula deg ees.
Flowabili y. De e mined using a slope measu ing de ice, acco ding o he p ocedu e desc ibed in
OFS.1.4.2.0016.15 "Flowabili y o Powde s" o he S a e Pha macopoeia o he Russian Fede a ion,
14 h edi ion. This is he ime du ing which a speci ied mass o a subs ance passes ( lows) h ough an
opening o a gi en size. Th ee consecu i e measu emen s we e conduc ed, and he a e age alue,
exp essed in seconds, was calcula ed. The measu emen was conduc ed unde di e en condi ions: in
he i s case, a 5 mm diame e unnel was used wi hou ib a ion; in he second case, he unnel
diame e was 10 mm, and he es was conduc ed on a ib a ion ig . Residual mois u e con en was
de e mined using an El iz-2S mois u e analyze . This ins umen ea u es a so wa e module ha
au oma es he p ocess o measu ing esidual mois u e in a sample. Be o e ope a ion, i is se o
au oma ic mode, a e which he d ying p og am is launched, which occu s unde he in luence o an
in a ed lamp buil in o he ins umen lid. Upon comple ion o he p ocess, he au oma ically
calcula ed pa ame e s a e displayed on a digi al display, calcula ions a e pe o med, and he
alphanume ic indica o displays he measu emen esul s: he pe cen age mois u e con en o he
pe cen age d y ma e con en o he sample . The comp essibili y o he es subs ance was
72
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
de e mined using a Hyd aulic P ess. Comp essibili y is assessed by he comp essi e s eng h o he
able s and is exp essed as absolu e alues (MPa) o as a comp essibili y coe icien , which is he
a io o he able mass o i s heigh . To de e mine he comp essibili y coe icien , a sample o 0.4
and 0.6 g o ma e ial was p essed in a 10 o 12 mm die, espec i ely, using a hyd aulic p ess. The
esul ing able s we e weighed on an analy ical balance o de e mine he able mass; he able heigh
was de e mined using a mic ome e .
Conclusions: Thus, based on a s udy o he subs ance's echnological cha ac e is ics, he need
o in oduce excipien s in o he able mass was iden i ied. To ob ain he able ed d ug, i is ad isable
o use a p elimina y we g anula ion me hod, which will p oduce high-quali y able s. I he
ecommenda ions and p oduc ion ules a e ollowed, he esul ing able s should mee quali y
indica o s and egula o y equi emen s.
