93
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
PHARMACEUTICAL INTERPOLYMER COMPLEXES BASED ON SODIUM
CARBOXYMETHYLCELLULOSE POLYSACCHARIDE AND POLYACRYLAMIDE
Sabi jan Y. Inagamo b#
Umma jon A. As o o a,c
Olimjon Т.Yomg’i o b
aNa ional Uni e si y o Uzbekis an named a e Mi zo Ulugbek, Tashken ci y, Uzbekis an
bTashken Pha maceu ical Ins i u e, Tashken ci y, Uzbekis an
cTashken S a e Pedagogical Uni e si y named a e Nizami, Tashken ci y, Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17322056
Rele ance: An analysis o in e na ional li e a u e da a shows ha polyelec oly e complexes
(PEC) a e e y p omising, occupy an impo an place in ma e ials echnology, enginee ing, medicine,
and o he a eas o he na ional economy, as hey e eal a numbe o unique and mos aluable
p ope ies. In addi ion, he abili y o many polyelec oly es o in e ac wi h o he polyme compounds
opens up b oad p ospec s in he ield o modi ica ion and con olled syn hesis o mac omolecula
sys ems. Due o his, comple ely new ma e ials can be ob ained om mos o he known subs ances.
Pu pose o he s udy: In his ega d, his wo k is de o ed o he s udy o new ca ie s o
medicinal pa icles based on sodium ca boxyme hyl cellulose (Na-CMC) and polyac ylamide (PAA).
Ma e ials and me hods: Na-CMC, ob ained on he basis o GOST 5.588-79, wi h a deg ee o
polyme iza ion (SP) - 70 and a deg ee o subs i u ion (SZ) - 450, was used as he main objec o he
s udy. Polyac ylamide, a polyelec oly e ob ained by polyme iza ion o ac ylamide con aining he
elemen ni ogen, which has a linea ly b anched s uc u e, was used as he second componen o he
PEC. IR spec a in he ange o 400-4000 cm-1 we e eco ded on NIKOLET Magna-560 IR and
Speco d–75 IR spec opho ome e s (Ka l Zeiss, GDR).
Resul s: When mixing aqueous solu ions o Na-CMC and PAA in a ious componen a ios a
pH = 5-6, a wa e -soluble PEC is o med. I is o med mainly due o he weak ionic bond be ween
he Na-CMC ca boxyla e anion and he amino g oups o PAA, which shows IR spec oscopic da a.
A change in he in ensi y and a shi in he abso p ion band in he egion o 1667 cm-1, 1609 cm-1
and in he egion o 1407 cm-1, 1451 cm-1 indica es he o ma ion o an ionic bond be ween he
ca boxyla e anions o Na-CMC and amino g oups o polyac ylamide, which gi es his PEC new
p ope ies ha di e om he ini ial componen s. The abo e expe imen al esul s a e con i med by
he physico-mechanical p ope ies o PEK ilms. The ilm s eng h o Na-CMC is σp = 6.1 MPa; o
PAA, σp = 22 MPa, and o PEK ilms o an equimola composi ion, i has a s eng h o σp = 38 MPa.
The elas ic de o ma ion o Na-CMC is ε =5.1%; o PAA, ε = 4.0%, and o PEK ilms wi h an
equimola composi ion, i has ε = 0.5%. The elas ici y o PEK ilms has E = 3.2 MPa o Na-CMC;
E = 8.1 MPa o PAA, and E = 73 MPa o PEK ilms wi h an equimola composi ion. All hese
changes in he p ope ies o ilms o polyelec oly e complexes a e associa ed wi h he o ma ion o
an ionic bond be ween he Na-CMC (CO-) ca boxyla e anions and he amine g oups o
polyac ylamide, which a e con i med by IR spec oscopic da a.
Conclusions: Thus, a new PEC based on Na-CMC and PAA was ob ained, which can be used
as ca ie s in medicinal p oduc s. The s uc u e and p ope ies o he polyelec oly e complex ha e
been s udied. I has been es ablished ha he s uc u es and physico-mechanical p ope ies o
polyelec oly e complexes can be con olled based on changes in he quan i a i e a ios o he
cons i uen componen s o Na-CMC and PAA.
