111
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
ASSESSMENT OF THE QUALITY INDICATORS OF THE BIOLOGICALLY
ACTIVE ADDITIVE BASED ON GERANIUM SANGUINEUM
Ab ayqulo a S.T.1
Tu aboe Sh.M.2
Sagdullae B.T.3
Tashken In e na ional Uni e si y o Chemis y, Tashken ci y, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17324090
Rele ance. Acco ding o s a is ical analyses, mos agen s used oday o he ea men o
in ec ious h oa diseases a e ob ained h ough chemical syn hesis, while p epa a ions de i ed om
na u al aw ma e ials a e ela i ely a e. I should be no ed ha physiologically ac i e na u al
compounds a e supe io o hei syn he ic analogues in e ms o sa e y indica o s. The composi ion
selec ed by scien is s o he Ins i u e o Bioo ganic Chemis y o he Academy o Sciences o he
Republic o Uzbekis an, based on plan aw ma e ials, has demons a ed e icacy in he ea men o
hese diseases. The e o e, ob aining a con enien dosage o m and s anda dizing i is o g ea
impo ance.
Aim o he s udy. E alua ion o he quali y indica o s o a biologically ac i e supplemen based
on Ge anium sanguineum and Glycy hiza glab a.
Ma e ials and me hods. The s udies on he e alua ion o he quali y indica o s o he
biologically ac i e supplemen we e ca ied ou in acco dance wi h he equi emen s o he Na ional
S anda d o Uzbekis an O‘zMS 166:2024 and he S a e Pha macopoeia o he Republic o
Uzbekis an.
Resul s. The composi ion o one able : ac i e subs ance – Ge an 0.25 mg; lico ice oo ex ac
(Glycy hiza glab a) – 5 mg; excipien s: so bi ol o manni ol – 970 mg, men hol o men hol oil – 5
mg, calcium s ea a e – 10 mg. To al able mass – 1000 mg. The able s appea ed as whi e o whi ish
ound able s wi h la edges and smoo h su aces. Thei appea ance complied wi h he equi emen s
o he S a e Pha macopoeia. Fo es ing, 20 able s we e andomly selec ed and weighed on an
FA1204B analy ical balance wi h an accu acy o 0.001 g. The a e age able mass was 0.991 g, wi h
de ia ions o +4.8% and -3.1%. The disin eg a ion ime was de e mined using he LB-2D appa a us.
The dissolu ion medium was 700 ml o pu i ied wa e , main ained a 37 ± 2.0 °C. A e illing he
essel wi h he medium and adjus ing o he equi ed empe a u e, six able s we e placed in he baske
ubes (one pe ube) and co e ed wi h discs, a e which he es was ini ia ed. All six able s
disin eg a ed comple ely wi hin 8–10 minu es and passed h ough he mesh. Table iabili y was
es ed on 10 able s. Thei ini ial mass was 9.8475 g, and a e he es hei mass was 9.8296 g. The
iabili y was calcula ed using he o mula: X = 100 – (m₁ – m₂ / m₁ × 100%) = 99.82%.
Conclusion. The s udy esul s showed ha he able dosage o m o he biologically ac i e
supplemen based on Ge anium sanguineum and Glycy hiza glab a, as an addi ional sou ce o
la onoids and glycy hizic acid complex, mee s he equi emen s o he Na ional S anda d O‘zMS
166:2024 wi h espec o quali y indica o s.
