153
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
COMPARATIVE STUDY OF THE SWELLING BEHAVIOR OF POLYMER
PATCHES BASED ON GELLAN GUM AND AGAR-AGAR
Kuldano a A.A.
Akhelo a A.L.
As endiya o Kazakh Na ional Medical Uni e si y,
Alma y, Republic o Kazakhs an
e-mail: [email p o ec ed], el. +7 775 519 2003
h ps://doi.o g/10.5281/zenodo.17328551
Rele ance: In ecen yea s, na u al polysaccha ides ha e been ex ensi ely s udied as p omising
componen s o he de elopmen o dosage o ms wi h con olled elease. Gellan gum, de i ed om
Sphingomonas elodea bac e ia, and aga -aga , ex ac ed om ed algae, a e cha ac e ized by a high
abili y o o m gels and s able h ee-dimensional s uc u es. These p ope ies make hem a ac i e
o use in biocompa ible ma e ials in ended o d ug deli e y. The inco po a ion o chi osan enhances
biocompa ibili y and adhesi e p ope ies, while glu a aldehyde ensu es chemical c oss-linking and
inc eases he mechanical s eng h o he ob ained pa ches. Thus, he in es iga ion o polyme
composi ions based on gellan and aga modi ied wi h chi osan and glu a aldehyde is o in e es o
he de elopmen o new ma e ials wi h p olonged he apeu ic ac ion.
Pu pose o he Resea ch: To in es iga e he swelling beha io o polyme pa ches based on
gellan gum and aga -aga , modi ied wi h chi osan and glu a aldehyde.
Ma e ials and me hods: To ob ain ilm samples, wo na u al polysaccha ides — gellan gum
and aga -aga — we e used. Polyme solu ions we e p epa ed in dis illed wa e by hea ing un il
comple e dissolu ion o he componen s, ollowed by cooling and cas ing on a la su ace. Samples
o s anda d mass we e imme sed in dis illed wa e and, a p ede e mined ime in e als, we e weighed
a e emo al o su ace mois u e wi h il e pape . The swelling deg ee was calcula ed as he a io o
he mass inc ease o he sample o i s ini ial mass.
Resul s: Gellan-based samples (G1, G2) exhibi ed apid swelling du ing he i s 40 minu es
bu showed educed s abili y unde p olonged wa e exposu e. Aga -based samples (A3, A4), in
con as , demons a ed uni o m wa e abso p ion and high s abili y agains hyd a ion.
Conclusions: The ob ained esul s con i m ha he na u e o he ini ial polysaccha ide and he
deg ee o chemical modi ica ion signi ican ly in luence he swelling beha io and s abili y o polyme
pa ches. Fu he esea ch will ocus on inco po a ing medicinal ex ac s in o he pa ch s uc u e and
in es iga ing hei elease kine ics, which will allow assessing he po en ial o he de eloped sys ems
as ca ie s o con olled deli e y o biologically ac i e subs ances.
