157
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
RESEARCH ON THE DEVELOPMENT OF A STOMATOLOGICAL
PHYTOTOOTHPASTE BASED ON LOCAL RAW MATERIALS
Rasulo a M.R.
Ziyamukhamedo a M.M.
Naza o a Z.A.
Shukh a ullaye a M.A.
Tashken Pha maceu ical Ins i u e, Tashken ci y, Republic o Uzbekis an
e-mail: [email p o ec ed], el: (90) 032-16-09
h ps://doi.o g/10.5281/zenodo.17328622
Rele ance: Phy o he apy is a ich and inexhaus ible sou ce o na u e, which p o ides he
possibili y o indi idual use o medicinal plan s, aking in o accoun he classi ica ion o diseases,
leading symp oms and synd omes, as well as hei e iopa hogenesis. As a esul , maximum
he apeu ic e ec can be achie ed wi h minimal side e ec s. P e en ion and ea men o o al ca i y
diseases is one o he u gen p oblems o mode n medicine. Cu en ly, oo hpas es a e among he
mos e ec i e hygienic means o he p e en ion o o al and den al diseases. Especially, oo hpas es
con aining alcohol-aqueous ex ac s o plan s imp o e he me abolic p ocesses o he o al ca i y,
p omo e issue egene a ion, possess an isep ic and immunoco ec i e p ope ies, and ha e an i-
in lamma o y, hemos a ic, wound-healing, s imula ing, deodo izing, and issue ophic-no malizing
e ec s. Ch onic in lamma o y p ocesses occu ing in he o al ca i y nega i ely a ec he gene al
condi ion o he whole o ganism. A p esen , he pha maceu ical ma ke o ou coun y is supplied
wi h a ious syn he ic and plan -based medicinal p oduc s o he ea men and p e en ion o
in lamma o y diseases o he o al ca i y. Today, he c ea ion o new dosage o ms based on local
medicinal plan s is one o he p essing asks o mode n pha macy.
The aim o he s udy. To de e mine he physicochemical and echnological p ope ies o he
s oma ological phy o oo hpas e de eloped on he basis o local aw ma e ials.
Me hods. The op imal composi ion and echnology o he s oma ological phy o oo hpas e we e
de eloped, wi h sodium ca boxyme hyl cellulose used as he pas e- o ming base. As a esul o he
conduc ed esea ch, i was ound ha some quali y indica o s o he p epa ed phy o oo hpas e—such
as appea ance, au hen ici y, uni o mi y, he mal and colloidal s abili y, and pH alue—comply wi h
he equi emen s o egula o y documen s.
The s uc u al composi ion o his so dosage o m and i s ansi ion o a lowing s a e is mainly
cha ac e ized by e ec i e iscosi y, which is ela ed o he in e nal ic ion o subs ances and laye s,
and he de o ma ional changes occu ing unde he in luence o shea s ess o low a e g adien .
Taking his in o accoun , heological s udies o he pas e unde shea low a di e en empe a u es
we e ca ied ou using he "Reo es -2" appa a us.
Resul s. Acco ding o he expe imen al esul s, he phy o oo hpas e has a non-New onian low
unde shea condi ions. The pas e beha ed as a s able sys em, since wi h he inc ease o empe a u e
om 25ºC o 40ºC, a dec ease in shea yield s ess was obse ed. In addi ion, he ha dness coe icien
dec eased om 34 Pa·s o 25 Pa·s, and he mechanical s abili y dec eased om 2.2 o 1.8.
Conclusions. The physicochemical and echnological p ope ies o he s oma ological
phy o oo hpas e we e de e mined. The oo hpas e is cha ac e ized by i s composi ion and alues o
shea yield s ess, s uc u al ha dness, and mechanical s abili y depending on empe a u e. Pas es wi h
such indica o s a e sui able o p ac ical applica ion as a so dosage o m.
