158
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
TECHNOLOGY OF OBTAINING DRY LYOPHILIC EXTRACT OF DESERT SAGE
(SALVIA DESERTA SHANGIN.)
Sagindyko a B.A.
Shoinbaye a G.B.Imanalie a S.M.
Sou h Kazakhs an Medical Academy, Shymken , Kazakhs an, [email p o ec ed],
con ac phone numbe : +7 707 712 55 65
h ps://doi.o g/10.5281/zenodo.17328637
Rele ance: Medicinal plan aw ma e ials a e an impo an sou ce o biologically ac i e
subs ances, which is why d y o ms a e p e e ed o he c ea ion o phy opha maceu icals due o
hei s abili y, ease o dosing, and s o age. The mos p omising me hod o ob aining such o ms is
lyophiliza ion, as lyophilized ex ac s a e supe io o con en ional d y ex ac s due o hei
p ese a ion o he molabile biologically ac i e subs ances, be e solubili y, s abili y du ing s o age,
ligh weigh s uc u e, p ecise dosing, and longe shel li e. Among he p omising plan s, he li le-
s udied dese sage (Sal ia dese a Schangin.), which g ows in Sou he n Kazakhs an, is o pa icula
in e es . Only medicinal sage is o icially egis e ed in Kazakhs an and included in he S a e
Pha macopoeia, o he ypes o sage a e poo ly s udied and a e no used in medicine. Ex ac s o he
dese sage oo ha e an ipla ele , an imic obial, and immunomodula o y e ec s. In his ega d, he
s udy o new poo ly s udied species o sage is an u gen p oblem. The de elopmen o echnology o
ob aining lyophilic ex ac s o dese sage is an u gen ask.
The pu pose o he s udy is o de elop a echnology o ob aining lyophilic ex ac o dese
sage.
Ma e ials and me hods. To ob ain he ex ac , d ied and c ushed abo eg ound pa s o dese
sage collec ed in he oo hills o Sou he n Kazakhs an we e used. To isola e biologically ac i e
subs ances, he me hod o ul asonic ex ac ion wi h 40% alcohol was used, ollowed by he emo al
o he ex ac an on a o a y e apo a o . Nex , he esul ing hick ex ac was lyophilized in a Ha es
Righ appa a us, USA. The quali y o he ex ac was de e mined by physico-chemical, echnological
and mic obiological me hods.
Resul s. Biologically ac i e subs ances we e isola ed by ul asonic ex ac ion, and a hick
ex ac was ob ained by dis illing he ex ac an on a acuum o a y e apo a o , which was eeze-
d ied o ob ain a d y ex ac .
Ex ac s ob ained wi h a 40% aqueous alcohol solu ion ha e a highe yield o ex ac i e
subs ances (3.7% mo e) compa ed o ex ac s ob ained wi h 70% e hyl alcohol. F eeze d ying
p o ides a highe yield o d y lyophilic ex ac (15.7%) and be e solubili y compa ed o d ying in a
d ying cabine (14.1%). All samples we e cha ac e ized by hyg oscopici y and absence o excess
hea y me al con en and mic obiological pu i y.
Conclusions. As a esul o he use o inno a i e echnology, a lyophilic ex ac o dese sage
was ob ained and he main pha macological and echnological cha ac e is ics o he d y ex ac we e
es ablished.
