166
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
STUDY OF RHEOLOGICAL PROPERTIES OF HYDROGELS BASED ON
OXIDIZED NANOCELLULOSE DERIVATIVES
U isho a F.M.
Kuzie a M.M.
Abi khudjae a Z.R.
A akhano A.A.
Ins i u e o Polyme Chemis y and Physics, Academy o Sciences o Uzbekis an, 100128,
Tashken ci y, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17328710
Nowadays, nanocellulose (NC) de i a i es a e used in a ious high-quali y unc ional
applica ions. One o hem is oxidized nanocellulose, which is used in he biomedical and
pha maceu ical ields due o i s biodeg adable, biocompa ible, hemos a ic and an ibac e ial
p ope ies. We syn hesized oxidized nanocellulose (ONC) ia po assium pe mangana e (KMnO₄)
oxida ion and in es iga ed he heological p ope ies o ONC-based hyd ogels.
Rheological cha ac e iza ion p o ides essen ial insigh s in o he mechanical in eg i y and
s abili y o hyd ogels. Bo h equency sweep and ampli ude sweep expe imen s we e conduc ed o
e alua e he iscoelas ic pe o mance o ONC hyd ogels. These es s allow di e en ia ion be ween
solid-like and liquid-like beha io , de e mina ion o he linea iscoelas ic egion (LVE), and
iden i ica ion o he yield poin , whe e he in e nal ne wo k collapses.
In equency sweeps, a s able gel is de ined by a equency-independen s o age modulus (G′)
domina ing o e he loss modulus (G″). All ONC hyd ogels exhibi ed G′>G″ h oughou he
equency ange, con i ming hei p edominan ly elas ic cha ac e . In con as , MCC showed a
ela i ely high damping ac o ( anδ≈0.9), consis en wi h weak elas ici y and iscous p edominance.
Oxida ion ma kedly enhanced ne wo k s eng h: ONC-2 displayed imp o ed elas ici y, while ONC-
3h achie ed he highes G′ alues (10⁴–10⁵ Pa) and he lowes an δ (~0.1–0.2), cha ac e is ic o a
s ong, s able gel ne wo k s abilized by ca boxyl g oups. ONC-4, howe e , exhibi ed declining G′ a
highe equencies, indica i e o ne wo k a igue and pa ial b eakdown caused by cellulose chain
scission du ing p olonged oxida ion.
Ampli ude sweeps u he cla i ied he s ain-dependen s abili y o gels. Wi hin he LVE, bo h
G′ and G″ emained cons an , e lec ing in ac ne wo ks; beyond his egion, G′ dec eased and
e en ually c ossed G″ a he yield poin . MCC hyd ogels displayed a na ow LVE and ea ly yielding
(γ≈15–20%), highligh ing poo esis ance o de o ma ion. ONC-2 ex ended he LVE sligh ly (~20–
25%), whe eas ONC-3 showed he b oades LVE (~25–30%) and he highes G′ pla eau,
exempli ying a “ ue gel” wi h excellen s abili y unde de o ma ion and s ong cohesi e o ces.
ONC-4 again yielded ea lie (~15–20%) wi h educed moduli, con i ming he de imen al e ec s o
excessi e oxida ion [1].
Taken oge he , bo h heological es s demons a e ha ONC-3 hyd ogels s ike he op imal
balance be ween unc ionaliza ion and s uc u al in eg i y. They combine equency-independen
elas ici y, a b oad LVE, and high yield s ain — hallma ks o obus gel ne wo ks. In con as , ONC-
2 and ONC-4 de ia e om his p o ile due o insu icien and excessi e oxida ion, espec i ely. These
indings a e highly ele an o he design o nanocellulose-based hyd ogels ailo ed o biomedical
applica ions such as mucoadhesion, d ug deli e y, and wound healing.
