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Volume 5, Issue 10: Special Issue
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ISSN: 2181-2020
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CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
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SPECTROSCOPIC ANALYSIS OF 2-METHYLTHIOBENZOXAZOLE AND THEIR
COMPLEX COMPOUNDS WITH 3D-METALS
Sadullae a S.A.
Na ional Uni e si y o Uzbekis an, Tashken ci y, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17335409
Rele ance o he esea ch: de i a i es o benzoxazole, which is a he e ocyclic compound
con aining ni ogen and oxygen, a e used in esea ch as a s a ing ma e ial o he syn hesis o many
bioac i e s uc u es, and many scien i ic s udies ha e been conduc ed on hei s uc u e and
p ope ies.
De i a i es o oxazole and 2-amino hiobenzoxazole a e ecognized as subs ances o medical
impo ance. I is known ha oxazole de i a i es a e subs ances wi h a ious pha macological e ec s.
Fo example, i is used as a emedy agains cance , mic obes, in lamma ion, he bicide, an ibac e ial,
an i i al, an ihis amine, an ioxidan , es ogen ecep o inhibi o , and hepa i is C i us. Compounds o
2-amino hiobenzoxazole also ha e luminescen p ope ies.
Pu pose o he s udy: Syn hesis o new complex compounds based on he ligand o
benzoxazole de i a i es o Co (II) and Cu (II) sal s and s udy o hei composi ion, s uc u e and
p ope ies, as well as de e mina ion o he egula i ies o complex o ma ion.
Me hods and echniques o he opic: Based on he esul s o IR spec oscopy o me al
complexes ob ained on he basis o 2-amino iobenzoxazole de i a i es o Co (II) and Cu (II) sal s,
he esul s o IR spec oscopy we e s udied.
Resul :Compa ing he IR spec a o L and i s complexes wi h cobal and coppe ni a e sal s, i
can be said ha he posi ion o symme ical alence ib a ions o he C=N bond and asymme ical
alence ib a ions o -C-N= in he spec a, du ing he ansi ion om he ligand o he complexes, a
he e ocyclic bond is o med, shi ed by 12-26 cm-1 o he i s o he low- equency egion, and by
3-10 cm-1 o he second (Table 1). The egions o asymme ic alence ib a ions o he C=N bond
shi o low equencies by 12-26 cm-1. This change can be explained by he shi in elec on densi y
du ing complex o ma ion a one o he ni ogen a oms o he oxazole ing. The posi ion o he alence
ib a ion egion o he S-CH3 bond, loca ed in he egion o 1031 cm-1, emains unchanged. Due o
he p esence o a small amoun o mois u e in he ligand molecule, he alence ib a ions also
occu ed in he egion o 3080-3271 cm-1, which emained unchanged in he complex, bu in he IR
spec um o he complexes, hese lines a e mo e esol ed and i has maxima a 3095 and 3271 cm-1.
Table 1
In he IR spec a o ligands (L) and complexes based on hem, he main oscilla ion
equencies (cm-1)
Bi ikma
(-
CH3)
(=C-
H)
(CH3-S-
)
(-C-N-
)
(-C=N-
)
(-C-O-
)
M-N
L
1628
1418
1031
3271
684
1519
-
[CoL2(NO3)2]
1621
1496
1094
3362
680
1556
419
[CuL2(NO3)2]
1624
1476
1044
3193
696
1551
419
Summa y: In he IR spec a o he complexes, he lines appea ing a 481-459 cm-1 a e
associa ed wi h he alence ib a ions o he N-M bond. Consequen ly, we can conclude ha he
coo dina ion o he e ocyclic ligands occu s a he expense o endocyclic ni ogen a oms. In he
spec um o he analyzed complex, an in ense band o symme ical alence ib a ions o he NO3-
313
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
g oup appea ed a 1375 cm-1. This indica es ha he ni a e g oup is monoden a ely a ached o he
cen al a om ia oxygen. Thus, acco ding o he IR spec oscopy o Co (II) complexes, he ni a e ion
is monoden a ely coo dina ed wi h he cen al a om as an acidoligand. The conclusions ob ained om
he IR spec um da a a e consis en wi h he esul s o X- ay.
