330
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
SYNTHESIS OF POLYMERIC NITROGEN DONATIONS BASED ON INULIN
DERIVATIVES
1Abduhomido a F.O.
2Khuseno A.Sh.
2Rakhmanbe die G.
2Ib agimo a K.S.
1Ka shi S a e Technical Uni e si y, Ka shi ci y, Republic o Uzbekis an
2Tashken Ins i u e o Chemical Technology, Tashken ci y, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17337056
Rele ance: Ni ic oxide (NO) dono s a e widely used in he ea men o ca dio ascula
diseases, pulmona y hype ension, and a e also ac i ely s udied in he ea men o neu odegene a i e
pa hologies. Such d ugs as Ni oglyce in, Molsidomine and Nico andil a e capable o eleasing ni ic
oxide. In he con ex o he g owing numbe o ch onic diseases and an aging popula ion, he e is a
g owing need o e ec i e and sa e means egula ing he bioa ailabili y o NO. In addi ion, he
imp o emen o syn hesis me hods makes i possible o ob ain ni ogen dono s wi h a gi en s uc u e
ha ensu es con olled elease o NO unde physiological condi ions o he body. Fo hese easons,
he de elopmen o new me hods o he syn hesis o ni ogen dono s wi h con olled elease and high
biocompa ibili y is becoming a pa icula ly in e es ing ask.
Pu pose o he s udy: Syn hesis o new ni ogen dono s by a ge ed chemical modi ica ion o
inulin es e s.
Ma e ials and me hods: Fo syn hesize ni ogen dono s, sodium sal o ca boxyme hylinulin
(CMI) was ini ially syn hesized by alkyla ion o he polysaccha ide in he p esence o
monochlo oace ic acid. Fo his, inulin was dispe sed in e hanol o 2 hou s, hen a 15% alkali solu ion
was added and s i ed o 1 hou . The eac ion was ca ied ou wi h Na-MCUA (sodium sal o
monochlo oace ic acid) a a mola a io o inulin:Na-MCUA=1:4, a empe a u e o 70°C o 1.5
hou s. Pu i ica ion was ca ied ou by ex ac ion wi h 96% e hanol, hen he samples we e d ied a
50-60°C. A KMI sample wi h a subs i u ion deg ee o 34 mol.%, d ied o a cons an weigh , was
es e i ied unde homogeneous condi ions wi h a ni a ing mix u e o he ollowing composi ion:
HNO3÷H3PO4÷P2O5, w .% = 20:75:5 a oom empe a u e o 30 minu es. Then he ni a ing mix u e
was pou ed in o a en old olume o ice-cold dis illed wa e , he esul ing whi e p ecipi a e o inulin
ni oes e was sepa a ed on a Scho glass il e and washed in dis illed wa e un il he washing wa e s
we e neu al, d ied in a acuum o en and analyzed.
Resul s: The FTIR spec a o he syn hesized compounds showed abso p ion bands wi h
maxima in he egion o 1650 cm-1 (N=O), 838 cm-1 (N-O), 1280 cm-1 (symme ic s e ching
ib a ions o N=O bonds), 1745 cm-1 (C=O). Elemen al analysis showed ha he weigh ni ogen
con en in he sample was 9.7% and i s subs i u ion deg ee o -NO2 g oups was 1.50 mol%. The
ob ained da a indica e he e iciency o ni a ion wi h p ese a ion o he main s uc u e o he
polysaccha ide. The subs i u ion deg ee indica es a pa ial bu con olled in oduc ion o ni o g oups,
which is impo an o subsequen egula ion o hei elease.
The a e o ni o g oup spli ing a pH 7.4 was s udied. Thus, i was ound ha ni o g oups
included in he polyme chain ha e a p olonged elease in a weakly alkaline medium. Wi hin 3, 6, 12
and 24 hou s, he a e o ni ogen oxide elease is 12, 37, 60 and 85%, espec i ely. These da a p o e
ha ni o g oups con ained in he inulin s uc u e a e uns able in a weakly alkaline medium and begin
o spli o wi hin 24 hou s.
331
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
Conclusions: The ob ained ni o de i a i es o inulin a e cha ac e ized by a con olled le el o
subs i u ion and he abili y o p olonged elease o ni ogen oxides in a weakly alkaline medium. This
con i ms hei po en ial as ni ogen dono s wi h con olled elease kine ics.
