363
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
STUDY OF THE BIOLOGICAL ACTIVITY OF THE COMPLEX COMPOUND [Cu
(Tsk)2](Glu)2 USING THE PASS ONLINE PROGRAM
Umi zako a O.T.
Nu aliye a G.A.
Na ional Uni e si y o Uzbekis an, Tashken ci y, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17337714
Rele ance o he s udy. he possibili y o assessing physicochemical p ope ies di ec ly by he
s uc u al o mula o he compound is ele an . Compa ison o hese pa ame e s o he syn hesized
compounds ob ained as a esul o calcula ions allows us o assess he con ibu ion o a ce ain
physicochemical cha ac e is ic o he de eloped ac i i y and a be e unde s anding o he mechanism
o ac ion o he p epa a ion.
Pu pose o he s udy. S udy o he s uc u e and p edic ion o po en ial biological p ope ies
o compounds:[Cu(Tsk)2](Glu)2.
Me hod and s yle. Pass-online applica ion
A powe ul se o me hods o p edic ing he biological ac i i y o chemical compounds on a
compu e is me hods based on Bayesian p obabili y. The Pass so wa e package is a p og am capable
o p edic ing he biological ac i i y spec a o chemical compounds known o da e. The Pass p og am
(online) is based on he s udy o he biological ac i i y o subs ances depending on hei s uc u e.
This p og am con ains known Pa and Pi alues o he subs ance, hese alues ep esen he heo e ical
p obabili y. Tha is, Pa is pha macologically ac i e, Pi is pha macologically inac i e. I Pa >0.71,
such a molecule is conside ed ac i e. The online pass p og am wo ks on he p inciple o s uc u al
biological ac i i y. In his case, he alue o Pa de e mines he pha macological ac i i y o he
subs ance agains a ce ain disease, and he alue o Pi de e mines he low pha macological ac i i y
agains his disease.
Resul s. Compu e calcula ions we e pe o med using he pass-Online p og am o de e mine
po en ial biologically ac i e subs ances. I was es ablished ha he syn hesized complex compounds
ha e high inhibi o y ac i i y agains enzymes.
Theo e ically calcula ed biological ac i i y o he [Cu(Tsk)2](Glu)2 molecule in he PASS-
online p og am
Summa y: Acco ding o he esul s o he analysis o he Pass-online p og am, i was
es ablished ha [Cu(Tsk)2](Glu)2 is a high inhibi o o enzyme complexes. I was es ablished ha
hese complex compounds ha e high ac i i y o alanine ansaminase and be a-ad ene gic ecep o
inhibi o .
0
0,2
0,4
0,6
0,8
10,901 0,845 0,837 0,802 0,703 0,746 0,701 0,635
Alanin ansaminaza ingibi o i
Be a-ad ene gik e sep o la i
ingibi o i
Le anaza ingibi o i
