377
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
CREATION OF NEW MEDICINAL PRODUCTS
Imamo a Y.A.
Egambe diye a M.A.
Sama kand S a e Medical Uni e si y, Sama kand ci y, Republic o Uzbekis an
e-mail: [email p o ec ed], el:(91)521-02-24
h ps://doi.o g/10.5281/zenodo.17339092
Rele ance. In ecen yea s, he de elopmen o new, mo e e ec i e d ugs has become a
p essing issue due o he inc easing le el o d ug esis ance. Acco ding o he Wo ld Heal h
O ganiza ion, mo e han 700,000 pa ien s die each yea om an ibio ic- esis an in ec ions.
The e o e, he c ea ion o new chemical classes o d ugs wi h a b oad spec um o ac ion and low
oxici y is one o he main p io i ies o he pha maceu ical indus y.
The pu pose o he s udy. To e alua e he pha macological ac i i y o 15 new compounds
syn hesized in 2023–2025, s udy hei sa e y indica o s, and de e mine he possibili ies o indus ial-
scale p oduc ion.
Me hods and me hodologies. Du ing he esea ch:
- Chemical syn hesis o 15 new compounds was ca ied ou ;
- Analgesic ac i i y was es ed in 60 whi e mice in he “ho pla e” es ;
- LD was de e mined o oxicological sa e y and he apeu ic indices o he d ugs we e
calcula ed.
Resul s. Six o he s udied compounds (40%) showed a high analgesic e ec , hei a e age
e icacy compa ed o mo phine sul a e was 85 ± 3%. In e ms o an i-in lamma o y ac i i y, ou
subs ances had a 1.3- old ad an age o e diclo enac. Toxicological s udies e ealed ha he LD ange
was 1500–2500 mg/kg, wi h a he apeu ic index o mo e han 10.
Conclusions. The esul s o he s udy showed ha 40% o he new compounds ha e high
analgesic and an i-in lamma o y ac i i y. Low oxicological isk indica o s and high he apeu ic index
allow hese d ugs o be ans e ed o he nex s age o es ing. These esul s p o ide a solid scien i ic
basis o he de elopmen o inno a i e d ugs in he pha maceu ical indus y.
