391
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
ALKYNYLATION REACTIONS OF SOME HETEROATOMIC ALDEHYDES IN THE
PARTICIPATION OF PHENYLACETYLENE
Saliye a M.K.1
Ziyadullaye O.E.2
1Tashken Pha maceu ical Ins i u e, Tashken , Uzbekis an
2Academy o he Minis y o Eme gency Si ua ions o he Republic o Uzbekis an,
Tashken , Uzbekis an
email: [email p o ec ed], el: (93)5933309
h ps://doi.o g/10.5281/zenodo.17339501
Rele ance: In ou coun y, he syn hesis o new ypes o chemicals ha ha e ound hei place
in he wo ld ma ke , he c ea ion o me hods o ob aining impo -subs i u ing compounds in ended
o expo , and hei use in he pha maceu ical, chemical, ene gy, and cons uc ion sec o s a e u gen
asks, and scien i ic esea ch is being conduc ed in his a ea and ce ain esul s a e being achie ed.
The pu pose o he esea ch: To ca y ou he syn hesis o ace ylenic alcohols based on he
alkynyla ion eac ion o some aldehydes con aining he e oa om subs i uen s in hei molecules wi h
phenylace ylene in he p esence o a new ca aly ic sys em InB 3/E 3N/E 2O, o sys ema ically s udy
he e ec o he mola a ios o he s a ing ma e ials, eac ion du a ion, empe a u e, na u e o he
ca alys and sol en s on he p oduc yield, and o de e mine he e iciency ange o he o ma ion o
ace ylenic alcohols based on he e ec o he e oa oms in he aldehyde molecule on he p oduc yield,
and o iden i y hei composi ion, pu i y, and s uc u e using physicochemical me hods.
Me hods and echniques: A new gene a ion o ace ylenic alcohols was syn hesized by
alkynyla ion o aldehydes con aining he e oa om subs i uen s - hiophene-2-ca baldehyde, u an-2-
ca baldehyde, and py idine-3-ca baldehydes wi h phenylace ylene in he p esence o he
InB 3/E 3N/E 2O ca aly ic sys em. The eac ion scheme is p oposed as ollows.
+
R
O
H
C CH R
H
OH
C C
1-3
InB 3E 3N/E 2O
20 o C, 120 min
S
H
OH
O
H
OH
H
OH
N
1 2 3
Resul s: The ollowing ace ylenic alcohols - 1-( hiophenyl-2)-3-phenylp opyn-2-ol-1 (1), 1-
( u anyl-2)-3-phenylp opyn-2-ol-1 (2), 1-(py idinyl-3)-3-phenylp opyn-2-ol-1 (3) - we e syn hesized
by alkynyla ion o aldehydes con aining he e oa om subs i uen s in he molecule - hiophene-2-
ca baldehyde, u an-2-ca baldehyde, py idine-3-ca baldehyde wi h phenylace ylene in he p esence
o he InB 3/E 3N/E 2O ca aly ic sys em. The e ec s o he mola a ios o he s a ing ma e ials,
eac ion du a ion, empe a u e, na u e o he ca alys and sol en s on he p oduc yield we e
sys ema ically s udied. Based on he e ec o he e oa oms in aldehyde molecules on p oduc yield,
he e iciency ange o ace ylenic alcohols was de e mined, and hei composi ion, pu i y, and
s uc u e we e iden i ied using physicochemical me hods.
392
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
Conclusions: Based on he esul s ob ained, he mos op imal condi ions o he syn hesis o
ace ylene alcohols in he InB 3/H2O/E 3N/E 2O ca aly ic sys em we e ound. Acco ding o hem, he
nucleophilic addi ion eac ions o phenylace ylene wi h selec ed aldehydes we e ca ied ou in a
die hyl e he solu ion in he p esence o he ca alys InB 3 o 120 minu es a a empe a u e o 20 °C,
wi h a 1:1 mola a io o he s a ing ma e ials, and he highes yield o ace ylene alcohols was
de e mined.
