In e na ional Jou nal o Clinical Science and Medical Resea ch
ISSN(p in ): 2770-5803, ISSN(online): 2770-582X
Volume 05 Issue 11 No embe 2025
DOI: h ps://doi.o g/10.55677/IJCSMR/V5I11-04/2025, Impac Fac o : 8.005
Page No : 291-294
291 A ailable a : h ps://jou nalo medical.o g/
Idiopa hic Cho oidal Neo ascula iza ion in Young Adul s: Repo o Two
Cases
H. Boui1, Z. Filali1, M. A. Hanine2
1Depa men o Oph halmology, Hassan II Mili a y Hospi al, Laayoune, Mo occo.
2Depa men o O o hinola yngology, Hassan II Mili a y Hospi al, Laayoune, Mo occo.
ABSTRACT Published Online: No embe 06, 2025
Idiopa hic cho oidal neo ascula iza ion (ICNV) is a a e bu po en ially ision- h ea ening
condi ion occu ing in pa ien s unde 50 yea s o age. I s e iology emains unclea , and he
disease o en a ec s he macula egion, leading o se e e isual impai men i un ea ed. We
epo wo cases o ICNV in young adul s success ully managed wi h in a i eal an i-VEGF
injec ions. These cases illus a e he diagnos ic app oach and highligh he a o able
p ognosis achie able wi h ea ly ea men .
KEYWORDS:
Idiopa hic cho oidal
neo ascula iza ion, an i-
VEGF, OCT, luo escein
angiog aphy, young adul s.
INTRODUCTION
Idiopa hic cho oidal neo ascula iza ion (ICNV) ep esen s
he second mos common cause o cho oidal
neo ascula iza ion (CNV) in pa ien s unde 50 yea s old,
a e pa hological myopia¹. I is cha ac e ized by he
p esence o sub e inal neo ascula memb anes in he
absence o p edisposing condi ions such as myopia, auma,
in lamma o y diseases, o he edi a y dys ophies². Due o i s
equen jux a o eal o sub o eal loca ion, ICNV poses a
majo isk o cen al ision. The in oduc ion o an i-VEGF
he apy has ma kedly imp o ed he unc ional p ognosis o
his condi ion³.
PATIENTS AND METHODS
Two pa ien s p esen ing wi h macula symp oms we e
e alua ed a he Depa men o Oph halmology, Hassan II
Mili a y Hospi al – Laâyoune. All unde wen comple e
oph halmologic examina ion, including undus pho og aphy,
luo escein angiog aphy (FA), and op ical cohe ence
omog aphy (OCT). An e iological wo kup was pe o med
o exclude seconda y causes o cho oidal neo ascula iza ion
(myopia, in lamma o y, in ec ious, o he edi a y e iologies).
T ea men consis ed o in a i eal injec ions (IVT) o
be acizumab (1.25 mg/0.05 ml), epea ed as needed based
on clinical and imaging indings.
Co esponding Au ho : H. Boui
*Ci e his A icle: H. Boui, Z. Filali, M. A. Hanine (2025).
Idiopa hic Cho oidal Neo ascula iza ion in Young Adul s:
Repo o Two Cases. In e na ional Jou nal o Clinical
Science and Medical Resea ch, 5(11), 291-294
CASE REPORTS
Case 1
A 26-yea -old male p esen ed wi h a sudden dec ease in
isual acui y in he le eye (LE). Visual acui y: 1/10 LE
(unco ec ed), 10/10 RE. An e io segmen : no mal in bo h
eyes. Fundus examina ion: macula sub e inal memb ane
wi h se ous e inal de achmen . OCT: loss o he o eal
con ou , dis up ion o he e inal pigmen epi helium (RPE),
and cen al e inal hickness o 461 µm. Fluo escein
angiog aphy: ea ly hype luo escence wi h la e dye leakage,
con i ming a cho oidal neo ascula memb ane (CNV).
T ea men wi h in a i eal be acizumab led o g adual
imp o emen in isual acui y and esolu ion o sub e inal
luid.
Case 2
A 46-yea -old emale p esen ed wi h dec eased isual acui y
in he igh eye (RE). Visual acui y: 5/10 RE, 10/10 LE.
An e io segmen : no mal bila e ally. Fundus examina ion:
macula CNV wi h e inal hickening. OCT: macula CNV
wi h exuda i e ea u es. FA: in ense ea ly hype luo escence
wi h la e leakage. The e iological wo kup was nega i e. She
ecei ed in a i eal be acizumab injec ions wi h mon hly
ollow-up and e ea men in case o pe sis ence o
ecu ence. Fa o able isual and ana omical ou comes we e
achie ed a e ea men .
DISCUSSION
ICNV accoun s o app oxima ely 17% o CNV cases in
pa ien s unde 50 yea s. The pa hogenesis emains unce ain,
hough hypo heses include localized de ec s in B uch’s
H. Boui e al, Idiopa hic Cho oidal Neo ascula iza ion in Young Adul s: Repo o Two Cases
292 A ailable a : h ps://jou nalo medical.o g/
memb ane and abno mal cho iocapilla is pe meabili y,
leading o neo ascula p oli e a ion benea h he RPE⁵.
DIAGNOSTIC APPROACH
Diagnosis elies on he combina ion o luo escein
angiog aphy and OCT. FA ypically shows an ea ly
hype luo escen lesion wi h p og essi e leakage⁶. OCT
e eals sub e inal hype e lec i e ma e ial, RPE de achmen ,
and se ous e inal de achmen . In unce ain cases, OCT-
angiog aphy (OCT-A) p o ides nonin asi e isualiza ion o
he neo ascula ne wo k⁷.
THERAPEUTIC MANAGEMENT
Be o e he ad en o an i-VEGF he apy, ICNV was ea ed
wi h pho odynamic he apy (PDT) o lase
pho ocoagula ion, wi h limi ed esul s and high ecu ence
a es⁸. Cu en ly, an i-VEGF agen s (be acizumab,
anibizumab, a libe cep ) cons i u e he i s -line he apy,
o e ing signi ican ana omical and isual imp o emen ⁹.
Mos pa ien s espond a o ably a e one o h ee injec ions,
hough ecu ence occu s in up o 25% o cases¹⁰. Regula
OCT moni o ing allows imely e ea men o p e en
ib osis and i e e sible pho o ecep o loss.
PROGNOSIS
The p ognosis o ICNV is gene ally be e han ha o CNV
associa ed wi h age- ela ed macula degene a ion (AMD).
Ea ly ini ia ion o an i-VEGF he apy, be o e he cica icial
phase, is essen ial o isual eco e y and o minimize
ecu ence¹¹. In young pa ien s, long- e m ollow-up emains
necessa y o de ec la e ecu ences o bila e al
in ol emen ¹².
CONCLUSION
Idiopa hic cho oidal neo ascula iza ion in young adul s,
al hough a e, should be p omp ly ecognized and ea ed.
Fluo escein angiog aphy and OCT emain key diagnos ic
ools. Ea ly an i-VEGF he apy allows o unc ional and
ana omical eco e y and g ea ly imp o es isual p ognosis.
Con inued moni o ing is essen ial o manage po en ial
ecu ences and p ese e cen al ision.
ICONOGRAPHY
Figu e 1 (A). Fundus pho og aph o Case 1 showing a macula sub e inal memb ane wi h se ous e inal de achmen .
Figu e 2 (B and C). Fluo escein angiog aphy o Case 1 displaying ea ly hype luo escence wi h la e dye leakage.
Figu e 3 (D). OCT scan o Case 1 e ealing o eal con ou loss and RPE dis up ion (cen al hickness: 461 µm).
H. Boui e al, Idiopa hic Cho oidal Neo ascula iza ion in Young Adul s: Repo o Two Cases
293 A ailable a : h ps://jou nalo medical.o g/
Figu e 4 (A). Fundus pho og aph o Case 2 showing a macula neo ascula memb ane.
Figu e 5(B and C). Fluo escein angiog aphy o Case 2 wi h in ense ea ly hype luo escence and la e leakage.
Figu e 6 (D). OCT o Case 2 showing sub o eal CNV wi h exuda ion.
Au ho Con ibu ions
D . BOUI Ha im: concep ion, da a analysis, manusc ip
d a ing.
D . FILALI Zineb: da a collec ion, c i ical e ision.
D . Hanine Mohamed Amine: da a collec ion, c i ical
e ision.
All au ho s app o ed he inal e sion o he manusc ip .
Con lic o In e es S a emen
The au ho s decla e no con lic o in e es ela ed o his
s udy.
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