REPO4EU News – No embe 2025
Dea colleague,
Welcome o he six h edi ion o he REPO4EU Newsle e !
Wi h ou hi d o icial anni e sa y now in he ea iew mi o and he end o
he yea apidly app oaching, we wan ed o ake a quick look back a
e e y hing ha has happened o sha e he key highligh s, s o ies and
b eak h oughs ha he REPO4EU eam has been an ac i e pa o in 2025.
F om he launch o ou pla o m's alpha e sion and he la es ad ances on
ou clinical ials, o exci ing u u e oppo uni ies o ne wo king and
collabo a ion: ead on o disco e wha we ha e been up o in ou jou ney o
make mechanism-based d ug epu posing a eali y, and o b ing sa e,
e ec i e and a o dable he apies o pa ien s.
P o , Ha ald Schmid
MD, PhD, Pha mD
Coo dina o o REPO4EU – Maas ich Uni e si y
In oducing he nex i e a ion o D ugs .One: ou solu ion o ne wo k
explo a ion ha u ns you ool ha ou pu s a lis o genes o p o eins in o a
ea u e- ich, d ug epu posing web applica ion wi h in e ac i e ne wo k
isualiza ion. This b and new e sion is called D ugs .One DREAM (D ug
Repu posing h ough Expe Anno a ion and Modi ica ion), and will p o ide
biomedical expe s wi h a use - iendly oolbox o disease module e inemen
ha does no equi e bioin o ma ics expe ise and is able o in oduce
addi ional ne wo k edi ing ea u es.
In he spo ligh
T y i ou
T y i ou
A e nea ly wo yea s o wo k and collabo a ion, he alpha e sion o ou d ug
epu posing pla o m is now a eali y. We a e in i ing scien is s, clinicians,
bioin o ma icians, egula o y expe s and anyone in ol ed in d ug epu posing
o ake pa in he pla o m’s ea ly es ing phase. Sounds in e es ing? Click
he link below o submi you in e es and become an ea ly- es e !
Regis e he e
Regis e he e
D ugs .One DREAM – Ne wo k explo a ion and d ug epu posing
Collabo a ion oppo uni ies
Ou 2026 B ussels policy e en on
Ma ch 18, wi hin he Eu opean
Pa liamen week, will ocus
squa ely on he cen al oadblock
sha ed ac oss p ecision-medicine
ields — om a e diseases and
epu posed d ugs o ad anced
he apies (ATMPs): he absence o
iable eimbu semen pa hways.
Whe he a he apy elies on a
egis e ed d ug ha is “ oo
inexpensi e” o jus i y in es men ,
o a ge s an ul a a e subg oup
wi h limi ed ma ke size, he esul
is he same: inno a ions s all be o e
eaching pa ien s. Building on he
concep s p esen ed in ou upda ed
HTA abs ac , we will con ene
egula o s, HTA bodies, indus y
pa ne s, and pa ien o ganisa ions
o explo e new, adap i e
eimbu semen models ha
suppo ea ly e idence,
mechanis ic s a i ica ion, and eal-
wo ld lea ning. We will also eam up
wi h pa allel ini ia i es om he
a e-disease and ATMP
communi ies o d i e a uni ied
agenda o sus ainable access. The
goal is clea : wi hou inno a i e
eimbu semen s a egies, all o
hese b eak h oughs isk ne e
making i o he clinic. This e en
aims o change ha .
Disco e ou Special In e es G oup
Disco e ou Special In e es G oup
Building on ou wo k in mechanis ic
disease mapping and pa ien -
empowe ed s a i ica ion, we a e
p epa ing a new Global Ra e
Disease Ini ia i e o alida e low-
cos , mechanism-based he apies
ac oss monogenic condi ions and
high-need pa ien g oups. The
concep combines p e-compu ed
disease modules, ac i e pa ien
o ganisa ions, and embedded n-o -
ew ial designs o accele a e
clinical ansla ion e en whe e
e idence is sca ce and pa ien
numbe s a e small.
This e o is now aking shape, and
we a e in i ing clinical pa ne s,
pa ien communi ies, and
me hodological inno a o s who
wan o co-c ea e his nex chap e
in a e-disease he apeu ics. I you
would like o engage, now is exac ly
he igh momen o join he
con e sa ion.
Unlocking eimbu semen o
p ecision medicine h ough
policy engagemen
A global a e disease ini ia i e
– Calling pa ne s o shape
he nex on ie
F esh o he p ess – La es news om REPO4EU
REPO-HYPER II ocuses on pa ien s wi h esis an hype ension whose
ele a ed blood p essu e is linked o a speci ic molecula pa hway also in ol ed
in s oke, myoca dial in a c ion, and hea ailu e. Ins ead o adding mo e
s anda d an ihype ensi e d ugs, he ial akes a mechanism-based ou e
ha di ec ly add esses he cause o ea men esis ance. By a ge ing his
pa hway, REPO-HYPER II aims no only o imp o e blood-p essu e con ol, bu
also o educe he isk o he majo ca dio ascula e en s ha cu en
he apies o en ail o p e en . Following a ou able assessmen by egula o y
and e hics au ho i ies, en olmen is expec ed o begin in Q1/26. The s udy will
p o ide he clinical-g ade e idence needed o alida e his s a egy and
suppo sus ainable eimbu semen models—ma king a shi owa d ou come-
d i en, p ecision ca dio ascula ca e.
REPO-HYPER II: A mechanism-d i en app oach o esis an
hype ension
Sys ems medicine examines diseases by hei unde lying molecula p ocesses
a he han by he o gans in which hey appea . By mapping how key p o eins
in e ac in disease-de ining ne wo ks, his app oach can e eal ea men
op ions ha a e bo h highly p ecise and ailo ed o he biology o indi idual
pa ien s. REPO4EU has now submi ed a pa en applica ion o a new
he apeu ic concep ha a ge s he co e d i e s o adioiodine-insensi i e
hy oid cance using a ionally designed combina ions o egis e ed small-
molecule medicines. The same s a egy is being ex ended o di use in insic
pon ine glioma (DIPG), one o he mos se e e childhood b ain cance s. This
miles one signi ican ly s eng hens he REPO4EU IP po olio and illus a es
how mechanism-based, indi idualised s a egies can open en i ely new
he apeu ic pa hways o cance s wi h p o ound unme medical needs.
A new, mechanism-based app oach o high-need cance s
Looking back on RExPO25 –
ou la es con e ence in
Ba celona
I ’s a w ap – Season 1 o ou
podcas is now a ailable
We can s ill eel he elec ici y and
he exci emen o his yea 's RExPO
- he in e na ional con e ence on
Sys ems Medicine, AI and D ug
Repu posing. Resea che s,
clinicians, policymake s and pa ien
g oup ep esen a i es came
oge he in Ba celona o sha e
knowledge and ideas on how o
ad ance d ug epu posing - click
he link below o eli e he
expe ience.
REPO4EU: The podcas b ings
lis ene s close o he la es
inno a ions, esea ch and
de elopmen s happening in d ug
epu posing ac oss he globe. The
i s season, ‘D ug Repu posing
Nex -Gen’, spo ligh s he wo k o
PhD esea che s, pos -docs and
young in es iga o s in ol ed in
REPO4EU, explo ing hei ole in he
p ojec as well as hei ca ee
jou neys.
Re isi he con e ence
Re isi he con e ence
Tune in o Season 1
Tune in o Season 1
The e is s ill ime o submi you esea ch o he Ne wo k and Sys ems
Medicine jou nal, a Diamond Open Access, pee - e iewed jou nal ocused on
in e disciplina y app oaches o exploi ing he powe o big da a by applying
ne wo k science and sys ems hinking o medicine. Click he link below o
lea n mo e abou key opics co e ed by he jou nal and he edi o ial boa d
behind i .
Calling o pape s o ou Ne wo k and Sys ems Medicine jou nal
Check i ou
Check i ou
© REPO4EU 2025
