EDITORIAL
published: 23 Janua y 2019
doi: 10.3389/ micb.2018.03338
F on ie s in Mic obiology | www. on ie sin.o g 1Janua y 2019 | Volume 9 | A icle 3338
Edi ed by:
Ma ias Collin,
Lund Uni e si y, Sweden
Re iewed by:
Thomas Hellma k,
Lund Uni e si y, Sweden
Pon us No den el ,
Lund Uni e si y, Sweden
*Co espondence:
Es eban A. He nandez-Va gas
[email p o ec ed]
Special y sec ion:
This a icle was submi ed o
In ec ious Diseases,
a sec ion o he jou nal
F on ie s in Mic obiology
Recei ed: 02 No embe 2018
Accep ed: 24 Decembe 2018
Published: 23 Janua y 2019
Ci a ion:
Kade ali L, Theis F, Ganuso VV,
Ciupe SM, Meh R, Ribei o RM and
He nandez-Va gas EA (2019) Edi o ial:
In eg a i e Compu a ional Sys ems
Biology App oaches in Immunology
and Medicine.
F on . Mic obiol. 9:3338.
doi: 10.3389/ micb.2018.03338
Edi o ial: In eg a i e Compu a ional
Sys ems Biology App oaches in
Immunology and Medicine
La s Kade ali1, Fabian Theis2, Vi aly V. Ganuso 3, S anca M. Ciupe4, Rami Meh 5,
Ruy M. Ribei o6and Es eban A. He nandez-Va gas7*
1Ins i u e o Bioin o ma ics, Uni e si ä smedizin G ei swald, G ei swald, Ge many, 2Helmhol z Zen um München,
Neuhe be g, Ge many, 3Depa men o Mic obiology, Uni e si y o Tennessee, Knox ille, Knox ille, TN, Uni ed S a es,
4Depa men o Ma hema ics, Vi ginia Tech, Blacksbu g, VA, Uni ed S a es, 5The Mina & E e a d Goodman Facul y o Li e
Sciences, Ba -Ilan Uni e si y, Rama Gan, Is ael, 6Faculdade de Medicina da Uni e sidade de Lisboa, Lisbon, Po ugal,
7F ank u Ins i u e o Ad anced S udies, F ank u am Main, Ge many
Keywo ds: ma hema ical modeling, sys ems biology, immunology, in ec ious diseases, i ology
Edi o ial on he Resea ch Topic
In eg a i e Compu a ional Sys ems Biology App oaches in Immunology and Medicine
New echnologies p o ide he abili y o gene a e massi e amoun s o immunological da a in heal h
and disease. Howe e , his “Big da a” end is becoming mo e challenging and un easible by he
s eep inc ease in he numbe o di e en pieces o in o ma ion and he complexi y o la ge da ase s.
Thus, sys ema ic and ac able app oaches ha in eg a e a a ie y o biological and medical esea ch
da a a mul iple scales in o ma hema ical, s a is ical, and compu a ional models a e c ucial o
ha ness knowledge and o de elop new he apies.
A “F on ie s in Immunology” and “F on ie s in Mic obiology” esea ch opic was p oposed o
add ess he cu en s a e o he a o bioin o ma ics and compu a ional models co e ing p ocesses
a mul iple empo al and/o spa ial scales (e.g., genes, molecula , cells, issues, o gans, indi idual,
and popula ion) and in combina ion wi h animal expe imen s and clinical da a. An addi ional
eason o p epa e his esea ch opic was o celeb a e he 70 h bi hday o Alan Pe elson, one o
he pionee s o ma hema ical modeling in i ology and immunology.
A o al o 23 pape s we e accep ed o publica ion, which a es s o he imeliness o he
opic. The pape s included in his Resea ch Topic e lec many o he open issues in heo e ical
immunology and in ec ious diseases. Some o he pape s add ess challenging ques ions—such as
he unde s anding o HIV and he immune sys em (Vaidya e al.;Mó éh e al.;He nandez-Va gas;
Yang and Ganuso ;Cangelosi e al.;Ciupe e al.), he e ec o pa asi es du ing a mala ia in ec ion
(Thak e e al.), how immune cells ope a e in ge minal cen e s (Ami ai e al.;Joslyn e al.) o in he
lymph nodes (Tasnim e al.); and he quan i ica ion o in luenza i al dynamics (Smi h e al.). Fou
pape s p oposed a mul iscale modeling app oach wi h he main goal o b ing oge he da a om
di e en scales (Ca u he s e al.;Quin ela e al.;Lehne and Figge;Zi zmann and Kade ali). The
p oblem o adi ional i ing me hods o ODEs applied o noisy p oblems was discussed in his
esea ch opic (Rome o-Se e son e al.). Ul ima ely, nume ical simula ions (Pigozzo e al.;Timme
e al.;P auße e al.) and bioin o ma ic ools (Pandey e al.;Naz e al.;Fa ías e al.;Ga g e al.) show
he impo ance o sys ems biology in unde s anding expe imen al ou comes.
These pape s p o ide a b oad o e iew o cu en issues in sys ems biology and we would like
o hank he F on ie s edi o ial s a , all he au ho s who con ibu ed excellen pape s, and he
e iewe s whose wo k has made publica ion o his esea ch opic possible.
Kade ali e al. In eg a i e Compu a ional Sys ems Biology App oaches
AUTHOR CONTRIBUTIONS
All au ho s lis ed ha e made a subs an ial, di ec and in ellec ual
con ibu ion o he wo k, and app o ed i o publica ion.
Con lic o In e es S a emen : The au ho s decla e ha he esea ch was
conduc ed in he absence o any comme cial o inancial ela ionships ha could
be cons ued as a po en ial con lic o in e es .
Copy igh © 2019 Kade ali, Theis, Ganuso , Ciupe, Meh , Ribei o and He nandez-
Va gas. This is an open-access a icle dis ibu ed unde he e ms o he
C ea i e Commons A ibu ion License (CC BY). The use, dis ibu ion o
ep oduc ion in o he o ums is pe mi ed, p o ided he o iginal au ho (s)
and he copy igh owne (s) a e c edi ed and ha he o iginal publica ion in
his jou nal is ci ed, in acco dance wi h accep ed academic p ac ice. No use,
dis ibu ion o ep oduc ion is pe mi ed which does no comply wi h hese
e ms.
F on ie s in Mic obiology | www. on ie sin.o g 2Janua y 2019 | Volume 9 | A icle 3338