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Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
SYNTHESIS OF POLYMER BASES BASED ON INULIN
1Abdullae O.Kh.
2Khuseno A.Sh.
2Rakhmanbe die G.
Ib agimo a K.S.
1Economic and Pedagogical Uni e si y, Ka shi ci y, Republic o Uzbekis an
2Tashken Ins i u e o Chemical Technology, Tashken ci y, Republic o Uzbekis an
e-mail: [email p o ec ed]
h ps://doi.o g/10.5281/zenodo.17337229
Rele ance: In ecen decades, esea che s ha e paid special a en ion o na u al polyme s as a
basis o c ea ing biocompa ible ma e ials ha a e widely used in medicine, pha maceu icals, ood
and cosme ics indus ies. One o hese p omising polysaccha ides is inulin, a plan
he e opolysaccha ide consis ing mainly o uc ose esidues. Inulin has a numbe o aluable
p ope ies: i is non- oxic, esis an o human diges i e enzymes and can be chemically modi ied,
which makes i a ac i e o ob aining new unc ional ma e ials. Due o i s bioa ailabili y and abili y
o s uc u al modi ica ion, inulin opens up wide oppo uni ies o c ea ing ma e ials wi h adjus able
p ope ies. Fo example, a ious polyme bases wi h speci ied physicochemical and biological
p ope ies can be c ea ed on he basis o inulin. In u n, polyme bases can ind applica ion as d ug
ca ie s, as well as as componen s o hyd ogel sys ems and composi e ma e ials.
Pu pose o he s udy: Syn hesis o polyme ic bases wi h di e en physicochemical p ope ies
by chemical modi ica ion o inulin.
Ma e ials and me hods: The polyme bases we e syn hesized by chemical modi ica ion o
inulin. Fo his pu pose, inulin was p elimina ily modi ied wi h hionyl chlo ide in a
dime hyl o mamide medium o 3 hou s and о=70оС. Then, hyd azine was added o he aqueous
solu ion o he syn hesized chlo inulin a a mola a io o inulin:hyd azine=1:1-5. The eac ion
p oceeded a о=50-70оС and a ime o 0.5-10 hou s. The ob ained samples we e pu i ied by dialysis
and isola ed by eeze-d ying. The syn hesized samples we e analyzed by FTIR spec oscopy, gel
ch oma og aphy, i a ion, elemen al analysis, and he pKα alue and he ze a po en ial alue we e
calcula ed.
Resul s: In he FTIR spec um o he inulin de i a i e con aining hyd azine agmen s, an
in ense abso p ion band was obse ed in he egion o 2874 cm-1 ela ed o he ib a ion o -NH2
g oups. Abso p ion in he egion o 1580 cm-1 was ela ed o he de o ma ion ib a ions o p ima y
amino g oups. The molecula weigh o amina ed inulin was 3500-5600 Da. Based on he ni ogen
con en , i was calcula ed ha he deg ee o subs i u ion o he syn hesized samples was 27-50 mol%.
Using he acidime ic i a ion me hod, i was ound ha he pKα alue o inulin de i a i es was 7.4-
8.0 and depended on he deg ee o subs i u ion. In addi ion, he in oduc ion o hyd azine molecules
in o he inulin s uc u e ga e he polysaccha ide a posi i e cha ge and hei ze a po en ial alue was
5.4-18.7 mV. F om his we can conclude ha he in oduc ion o hyd azine molecules in o he
s uc u e o inulin p o ides he en i e mac ochain wi h he p ope ies o polyme ic bases.
Conclusions: By means o chemical addi ion o hyd azine o chlo inulin new de i a i es wi h
p ope ies o polyme bases we e syn hesized. The s uc u e, molecula weigh and p ope ies o he
ob ained de i a i es o inulin we e s udied by me hods o FTIR spec oscopy, gel ch oma og aphy,
elemen al analysis, acidime ic i a ion, e c. Fi s o all, he de eloped me hod o inulin modi ica ion
allows o con ol he p ope ies o he polyme chain, opening up possibili ies o u he a ge ed
applica ion.
