367
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
DEVELOPMENT OF BIODEGRADABLE BANDAGES FROM PINUS SYLVESTRIS
BARK: PHYTOCHEMICAL ANALYSIS AND BIOLOGICAL ACTIVITY
Chapaksin I.V.
Chapaksina B.N.
Sey eno a A.K.
Kos anay Highe Medical College, Kos anay, Kazakhs an
e-mail: [email p o ec ed], el.: +77059159900
h ps://doi.o g/10.5281/zenodo.17337797
Rele ance. Mode n medicine has an u gen need o en i onmen ally iendly, biocompa ible,
and e ec i e wound d essing ma e ials. The ba k o Sco s pine (Pinus syl es is) is a p omising
enewable sou ce o biologically ac i e compounds wi h p o en an imic obial and wound-healing
p ope ies, which de e mines he ele ance o i s s udy.
Objec i e o he s udy: To subs an ia e he possibili y o using Pinus syl es is ba k o he
de elopmen o en i onmen ally iendly wound d essing ma e ials wi h enhanced an isep ic
p ope ies.
Ma e ials and Me hods: A phy ochemical analysis o he ba k was ca ied ou using IR
spec opho ome y and hin-laye ch oma og aphy. A echnology o p ocessing he ba k in o ib ous
ma e ial was de eloped, including he s ages o cleaning, ibe iza ion, and s abiliza ion. The
an imic obial ac i i y and esis ance o biodeg ada ion we e e alua ed unde incuba ion condi ions
wi h ungal cul u es Aspe gillus nige and Penicillium ch ysogenum. The physico-mechanical
p ope ies o he ob ained samples ( ensile s eng h, mois u e abso p ion, ai pe meabili y) we e also
s udied.
Resul s: I was ound ha pine ba k is ich in la onoids (que ce in, kaemp e ol), phenolic acids
(ca eic, e ulic), and e penoids (α-pinene), which accoun o i s s ong an ioxidan and an isep ic
ac i i y. The de eloped bandages demons a ed supe io cha ac e is ics compa ed o syn he ic and
gauze analogues: ensile s eng h — 45 N, mois u e abso p ion — 180%, ai pe meabili y — 2.5
cm³/cm²/s. A biodeg ada ion esis ance expe imen showed ha imp egna ion wi h ya ow ex ac
signi ican ly inc eased he ma e ial’s esis ance o ungal des uc ion (a ec ed a ea o only 15%
e sus 40% in he un ea ed sample and 70% in he syn he ic sample on day 14).
Conclusions: The esul s o he s udy con i m he po en ial o Sco s pine ba k o he
p oduc ion o biodeg adable, biocompa ible wound d essing ma e ials wi h p olonged an isep ic
ac i i y. Fu he esea ch will ocus on op imizing he echnology and conduc ing p eclinical ials.
