376
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE “MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
ʼPEROVSKIA KUDRJASCHEVII – A PROMISING SOURCE OF BIOLOGICALLY
ACTIVE TERPENOIDS
Ik omo a G. M.1
Bo i o E. Kh.2
1Namangan S a e Uni e si y, Namangan, Republic o Uzbekis an,
e-mail: [email p o ec ed], phone (+998) 99 398 22 98
2Ins i u e o Plan Chemis y named a e academician S.Yu. Yunuso , AS RUz, Tashken
h ps://doi.o g/10.5281/zenodo.17339069
Rele ance: Pe o skia kud jasche ii Go schk. & Pja ae a ( amily Lamiacaeae) is a medicinal,
essen ial oil, dye and honey plan . I is ound in Uzbekis an, Tajikis an and Ky gyzs an. The chemical
composi ion o he componen s o Pe o skia kud jasche ii has no been p e iously s udied.
Pu pose o he s udy. Isola ion and s udy o biologically ac i e componen s o he abo e-
g ound pa and oo s o Pe o skia kud jasche ii, collec ed in he Bos andyk dis ic o he Tashken
egion.
Ma e ials and me hods. C ushed ai -d ied plan ma e ials we e ex ac ed i e imes a oom
empe a u e wi h me hanol. The combined ex ac was e apo a ed in acuo, dilu ed wi h wa e and
subjec ed o liquid-liquid ex ac ion wi h benzene, chlo o o m, e hyl ace a e and n-bu anol.
Resul s. Two phenolic ca boxylic acids, one di e penoid and wo phy os e ols we e isola ed
om di e en ac ions o he me hanol ex ac o he ae ial pa s by column ch oma og aphy on
silica gel and Sephadex LH-20. Based on he s udy o UV, 1H and 13C NMR spec a he isola ed
subs ances we e iden i ied wi h ca eic and osma inic acids, e uginol, β-si os e ol and s igmas e ol.
Fou een indi idual compounds we e isola ed om he me hanol ex ac o he oo s by column
ch oma og aphy on silica gel and Sephadex LH-20. Based on he s udy o UV, 1H and 13C NMR
spec a he isola ed subs ances we e iden i ied wi h he bis-no -di e penoid p zewalskin, no -
di epenoids c yp o anshinone and anshinone IIA, di epenoids 7α-ace oxy- oileanone and sujiol,
i e penoids e y h odiol 3β-ace a e, olean-12-ene-3β-O-ace yl-28-al, oleanolic acid and oleanolic
acid 3-ace a e. In addi ion o he abo e compounds, β-si os e ol, s igmas e ol, ca eic and osma inic
acids we e isola ed and iden i ied om he oo s. The spa ial s uc u e o 7α-ace oxy oileanone,
e y h odiol 3β-ace a e and olean-12-ene-3β-O-ace yl-28-al was es ablished by X- ay di ac ion
analysis (XRD). The XRD ma e ials o he abo e compounds we e deposi ed a he Camb idge
C ys allog aphic Da a Cen e.
All he isola ed compounds ha e a di e se spec um o pha macological p ope ies.
C yp o anshinone is cha ac e ized by an icance , an i-in lamma o y, immuno egula o y,
neu op o ec i e and an i ib o ic ac i i y. C yp o anshinone exhibi s a p onounced an i-in lamma o y
e ec in he expe imen , supp essing bo h he exuda i e and p oli e a i e phases o in lamma ion. In
e ms o he se e i y o i s ac ion, c yp o anshinone has shown ce ain ad an ages o e diclo enac.
Tanshinone IIA dila es co ona y a e ies and inc eases co ona y blood low due o he ac i a ion o
po assium channels, has a ca diop o ec i e and an i-in lamma o y e ec .
Conclusions. I has been shown ha he Pe o skia kud jasche ii plan is a ich sou ce o
biologically ac i e phenolic ca boxylic acids, di e penoids, i e penoids and can be used o c ea e
e ec i e d ugs and die a y supplemen s.
