SCIENCE AND INNOVATION
INTERNATIONAL SCIENTIFIC JOURNAL VOLUME 4 ISSUE 10 OCTOBER 2025
ISSN: 2181-3337 | SCIENTISTS.UZ
230
ANALYSIS AND STUDY OF THE CLINICAL
MANIFESTATIONS OF ALLERGIC DISEASES IN CHILDREN
BORN TO MOTHERS SUFFERING FROM ALLERGIC
DISEASES
M.B. De o o a1, M.J. Tu sunboye a2, Sh.M. Yusupo a3
PhD, Associa e P o esso o he Depa men o Family Doc o No. 1, Physical Educa ion and
Ci il De ense a Tashken S a e Medical Uni e si y1,2,3
h ps://doi.o g/10.5281/zenodo.17538787
Abs ac . The a icle p esen s da a om a li e a u e e iew conce ning he s udy o clinical
mani es a ions o alle gic diseases in child en bo n o mo he s su e ing om alle gic pa hology.
These aspec s a e o g ea impo ance o medical p o essionals, especially pedia icians.
Howe e , he in es iga ion o his issue emains an open and p essing ques ion.
Keywo ds: p oblem, child en, pa hology, p e alence, aspec s.
In oduc ion
P oblems associa ed wi h alle gic pa hology in child en ha e sha ply inc eased o e he
pas decades. Acco ding o s a is ical da a, he numbe o child en su e ing om alle gic diseases
has mo e han doubled in he las i e yea s. Resea ch indings indica e ha 40% o he a ec ed
popula ion a e young child en: 54% o hem su e om a opic de ma i is, and in 10% o cases,
he i s symp oms o b onchial as hma appea du ing he i s yea o li e. Mode n gene ic analyses
ha e shown ha abou 70% o child en who de elop alle gic pa hology a an ea ly age ha e a
amily his o y bu dened by simila diseases. The deg ee o isk is de e mined by he na u e o
inhe i ance and en i onmen al ac o s, including he cou se o deli e y, ype o eeding, li ing
condi ions, and pa en s’ ha m ul habi s.
Acco ding o li e a u e da a, i is well known ha alle gic in lamma ion is based on
ad ene gic ecep o dys unc ion and hype p oduc ion o IgE by immunocompe en cells. The s udy
o ad eno ecep o diso de s in ecen yea s has led o he de elopmen o a concep o gene alized
be a-ad eno ecep o pa hology, which a ec s all cells and issues o he body. Essen ially, his is
ega ded as a mani es a ion o on ogene ic imma u i y o he memb ane- ecep o s uc u es o
body cells. Gene ic s udies ha e iden i ied associa ions be ween ce ain a ian s o he β₂-
ad eno ecep o gene and alle gic diseases. An in o ma ion e iew e ealed ha , despi e he
ela i ely well-s udied sensi i i y o be a-ad eno ecep o s in adul s su e ing om alle gic
diso de s, ques ions ega ding he condi ion o be a-ad eno ecep o s in newbo ns and young
child en wi h a he edi a y p edisposi ion o alle gic pa hology emain insu icien ly explo ed.
Mo eo e , he e a e no da a on he impac o ma e nal ch onic diseases on he de elopmen o
ad eno ecep o dys unc ion in newbo ns.
Un il ecen ly, one o he gene ally accep ed me hods o p edic ing alle gic diseases in
newbo ns was he de e mina ion o eosinophil coun and IgE le els in umbilical co d blood.
Howe e , ecen s udies ha e demons a ed ha hese labo a o y indica o s canno be conside ed
eliable ma ke s o he men ioned isk. Epidemiological s udies o ecen yea s con i m a high
p e alence o b onchial as hma (BA) among bo h child en and adul s, a e aging om 5% o 10%.
SCIENCE AND INNOVATION
INTERNATIONAL SCIENTIFIC JOURNAL VOLUME 4 ISSUE 10 OCTOBER 2025
ISSN: 2181-3337 | SCIENTISTS.UZ
231
B onchial as hma belongs o he g oup o mul i ac o ial diseases (MFDs), he e iology and
pa hogenesis o which a e de e mined by a complex in e ac ion o gene ic and en i onmen al
ac o s.
In he mani es a ion o gene ically de e mined de ec s, ex e nal in luences on he mo he ’s
and child’s bodies play a signi ican ole — such as unbalanced nu i ion, high an igenic load,
espi a o y in ec ions, and o he causes. The beginning o he 21s cen u y has been ma ked by an
ala ming inc ease in he numbe o pa ien s wi h a ious alle gic diseases, among which b onchial
as hma anks i s . The main cause o his inc ease is conside ed o be he g owing an igenic load
on he human body in he e a o en i onmen al agg ession and wes e niza ion o li es yle.
Acco ding o domes ic esea che s, o example, in S . Pe e sbu g, abou 20% o he
popula ion su e s om alle gic diseases, including 7.3% wi h b onchial as hma. I should also be
no ed ha he se e i y o alle gic diseases, pa icula ly b onchial as hma, is inc easing wo ldwide.
This is la gely due o la e diagnosis, which leads o delayed ini ia ion o ea men .
The p esen ed ac s lead o he conclusion ha i is necessa y o sea ch o new ways o
p e en he de elopmen o alle gic diseases, pa icula ly b onchial as hma (BA). Acco ding o he
li e a u e, b onchial as hma is a se ious ch onic disease ha poses a signi ican public heal h
p oblem. This disease has a he edi a y p edisposi ion. The ealiza ion o gene ically de e mined
de ec s is in luenced by ad e se en i onmen al and occupa ional ac o s a ec ing he mo he and
e us, unbalanced nu i ion, high alle gen exposu e in he child’s body, espi a o y in ec ions, and
o he causes. The highe he deg ee o p edisposi ion o alle gy, he less ex e nal exposu e is
equi ed o he disease o mani es . Unde s ong exposu e o a combina ion o alle genic ac o s,
e en child en wi h a mino p edisposi ion may de elop alle gic diseases.
B onchial as hma is no a con aindica ion o p egnancy, bu poo ly con olled disease
du ing his pe iod ad e sely a ec s he heal h o bo h he mo he and he unbo n child.
Epidemiological s udies among p egnan women ha e shown ha b onchial as hma is qui e
common in his g oup — acco ding o a ious au ho s, om 1% o 13.8% o p egnan women
su e om his disease. Specialis s ha e es ablished ha he se e i y s uc u e o he disease in
p egnan women app oxima ely co esponds o ha o b onchial as hma in gene al, i.e., pa ien s
wi h mild o ms p edomina e (65–70%).
Ea lie s udies indica ed an app oxima ely equal numbe o pa ien s epo ing
imp o emen , wo sening, o s able cou se o b onchial as hma du ing p egnancy. Howe e , ecen
da a demons a e a endency owa d an inc eased numbe o cases wi h exace ba ion o he disease.
Resea ch conduc ed in ecen yea s has shown ha placen al insu iciency and e al g ow h
e a da ion we e mo e o en obse ed in women who did no ecei e ea men o b onchial
as hma. A he same ime, pa ien s wi h con olled disease success ully ca ied p egnancies o e m
and ga e bi h o heal hy child en when imely basic he apy was p esc ibed. A p esen , he e is
no es ablished sys em ha allows o p ima y p e en ion o alle gic diseases — pa icula ly
b onchial as hma — in child en bo n o mo he s su e ing om his condi ion.
The au ho s ha e con i med ha , in mos cases, alle gy ep esen s he ini ial sensi iza ion,
agains which hype sensi i i y o o he ypes o alle gens de elops, leading o a ious ch onic
alle gic and gas oen e ological pa hologies. Mo eo e , he spec um o in ole able oods changes
wi h age: while he ini ial sensi iza ion is mos o en caused by cow’s milk p o eins (CMP), in
olde child en, alle gies o oods such as ish, honey, nu s, ci us ui s, and o he s become mo e
common. In in an s du ing hei i s yea o li e who a e on a i icial o mixed eeding, he success
o die a y he apy la gely depends on he co ec selec ion o a b eas milk subs i u e. To op imally
SCIENCE AND INNOVATION
INTERNATIONAL SCIENTIFIC JOURNAL VOLUME 4 ISSUE 10 OCTOBER 2025
ISSN: 2181-3337 | SCIENTISTS.UZ
232
sol e his p oblem, i is necessa y o de elop a mode n, di e en ia ed, and scien i ically g ounded
app oach.
An addi ional challenge is he co ec ion o he nu ien composi ion o he die in olde
child en and adolescen s su e ing om long- e m alle gies and ha ing es ic ed die s ha exclude
nu i ionally impo an oods. I should be no ed ha he du a ion o elimina ion die s is no clea ly
de ined a p esen . In his ega d, i is necessa y o cla i y he clinical and immunological c i e ia
ha de e mine he du a ion o elimina ion o a ious oods and he iming o hei ein oduc ion
in o he child’s die du ing nu i ional expansion, as well as o de elop app oaches o die a y
co ec ion in pa ien s on long- e m elimina ion die s using mode n nu aceu icals.
Expe s ha e also con i med ano he impo an ac o : he o al ou e o alle gen exposu e
leads o he de elopmen o a ious gas oin es inal diso de s in mos pa ien s wi h alle gies. The
na u e o hese diso de s a ies depending on he child’s age and he se e i y o sensi iza ion. The
ole o non-IgE-media ed mechanisms in he o ma ion o gas oin es inal mani es a ions o
alle gy is no ye ully unde s ood and equi es u he in es iga ion. In ecen yea s, he e has been
ac i e esea ch in o he in luence o in es inal mic o lo a on he de elopmen o he immune
sys em. Va ious dis u bances in he composi ion o he in es inal mic obio a a e equen ly
obse ed in child en su e ing om ood alle gies. S udies ha e shown ha he in es inal
mic o lo a o heal hy child en di e s om ha o child en wi h a opy — a opic child en ha e a
educed numbe o lac obacilli and an inc eased numbe o coli o m bac e ia and S aphylococcus
au eus.
When p o ound al e a ions occu in he in es inal biocenosis—cha ac e ized by
supp ession o p o ec i e mic o lo a and ac i e p oli e a ion o condi ionally pa hogenic
mic oo ganisms— hese changes a ec he cou se o he alle gic p ocess, con ibu ing o i s
agg a a ion. Howe e , he pa hogene ic signi icance o in es inal mic obio a dis u bances in
alle gic child en has no been ully elucida ed. Clinicians no e ha die a y he apy is a key
componen o comp ehensi e alle gy ea men , being essen ially an e io opic me hod o he apy.
When de eloping a he apeu ic die , p ima y a en ion is gi en o he elimina ion o causa i e
oods. A he same ime, ega dless o he s age o he disease, he die mus mee he physiological
needs o child en o essen ial nu ien s, i amins, and mine als. The apeu ic nu i ion o alle gies
has i s own speci ic ea u es a di e en ages. Thus, summa izing he li e a u e e iew, i can be
concluded ha u he esea ch in his a ea o medicine is o signi ican alue.
A posi i e amily his o y o alle gic pa hology is conside ed one o he mos signi ican
isk ac o s o he de elopmen o hese diseases in child en. The p esence o b onchial as hma in
pa en s signi ican ly inc eases he isk o he disease in o sp ing. When compa ing pa en al lines,
he ma e nal his o y o as hma has a mo e p onounced e ec han he pa e nal one, which con i ms
he impo ance o in au e ine ac o s in he o ma ion o alle gy and b onchial as hma in pa icula .
Fu he analysis o li e a u e sou ces has shown ha in s udies de o ed o he cou se o
p egnancy in women wi h b onchial as hma, he heal h s a us o he child was ound o depend on
he se e i y and con ollabili y o he mo he ’s disease du ing p egnancy. Howe e , only a ew
s udies ha e p esen ed long- e m ollow-up da a on child en bo n o mo he s wi h b onchial
as hma. P ac ically no s udies ha e in es iga ed he in luence o he clinical and pa hogene ic
ea u es o ma e nal b onchial as hma on he o ma ion o alle gic pa hology in he child. In
addi ion, he e a e e y limi ed da a on he in e ac ion o genes in ol ed in he gene ic ne wo k o
b onchial as hma and hei in luence on he de elopmen o he alle gic s a us o child en bo n o
mo he s wi h his disease.
SCIENCE AND INNOVATION
INTERNATIONAL SCIENTIFIC JOURNAL VOLUME 4 ISSUE 10 OCTOBER 2025
ISSN: 2181-3337 | SCIENTISTS.UZ
233
Conclusion. Thus, a e iew o he li e a u e allows us o conclude ha i is ele an and
necessa y o s udy he geno ypic and pheno ypic cha ac e is ics o child en bo n o mo he s
su e ing om b onchial as hma, as well as o iden i y hei isk o de eloping alle gic pa hology
h ough dynamic obse a ion. Knowledge o he un a o able gene ic p o ile a bi h will make i
possible o iden i y high- isk g oups o he de elopmen o his pa hology, and expanding ou
unde s anding o he ac o s in luencing alle gic disease o ma ion in child en will help de elop
me hods o ea ly p e en ion o hese diso de s.
REFERENCES
1. I sha He Dok o de his o ischen Wissenscha en. (B a isla a, Slowakei)
2. Kho oshke ych A. L. Dok o de his o ischen Wissenscha en (Moskau, Russland)
3. E molenko C. Dok o de philologischen Wissenscha en (Kiew. Uk aine)
4. In Качкан. Dok o de philologischen Wissenscha en (Iwano-F ankiwsk, Uk aine)
5. De o o a M.B. Alle gic diseases in child en. Wo ld Bulle in o Public Heal h (WBPH)
Журналы Schola Exp ess.Берлин,Германия.Volume-31,Feb ua y 2024.С.111-113.
6. Smi h P.K., Collins J. Ca ney A.S. In e na ional Consensus S a emen on Alle gy and
Rhinology: Alle gic Rhini is//In Fo um Alle gy Rhinol.2023;13(Suppl 1):S1-S70.
7. De o o a M.B., Koshimbe o a G.K In luence o alle gic ecu en obs uc i e b onchi is on
physical de elopmen o p eschool child en In e na ional Vi ual Con e ence on Language
and Li e a u e P oceeding. Pa .4 h ps://doi.o g/10. 5281/zenodo.10113496 Indonesia
Janua y June 2024-2. C. 34-35;
8. De o o a M.B. Cu en aspec s o ea men and complica ions o co id in child en wi h
alle gic diseases (li e a y e iew) Wo ld Bulle in o Public Heal h .Журналы Schola
Exp ess. A ailable Online a : h ps://www.schola exp ess.ne Берлин, Германия Volume-22,
May 2023. С.33-36;
9. Sh e s N.G., Dok o de Wi scha swissenscha en, P o esso ;
10. Bocha o V. A., de Dok o de medizinischen Wissenscha en, P o esso , de Odessa
Medical Ins i u e des In e na ionalen humani ä en Uni e si ä ;
11. Waldema Wójcik, Dok o de echnischen Wissenscha en, P o esso , Lubline öko-
Uni e si y o Technology;
12. Webe A. I., Dok o de poli ischen Wissenscha en, P o esso de Kiewe na ionalen Ta as-
Sche-w schenko-Uni e si ä ;
