scieee Science in your language
[en] (orig)

Modulation of angiogenic pathways by 8-prenylnaringenin

Abstract

Resumo

Read accessible full text

Modulation of angiogenic pathways by 8-prenylnaringenin

Author: Guerra, AC.,Faria, A.,Calhau, C.,Soares, R.,Negrão, R.
Year: 2014
Source: https://repositorio-aberto.up.pt/bitstream/10216/84874/2/95707.pdf

0RGXODWLRQRIDQJLRJHQLFSDWKZD VE SUHQ OQDULQJHQLQ
$&*XHUUD$)DULD &&DOKDX 56RDUHVDQG51HJUmR
'HSDUWPHQWRI%LRFKHPLVWU 8)&7)DFXOW RI0HGLFLQH8QLYHUVLW RI3RUWR3RUWXJDO
&KHPLVWU ,QYHVWLJDWLRQ&HQWUH&,4'HSDUWPHQWRI&KHPLVWU )DFXOW RI6FLHQFHV
8QLYHUVLW RI3RUWR3RUWXJDO
)DFXOW RI1XWULWLRQDQG)RRG6FLHQFHV8QLYHUVLW RI3RUWR3RUWXJDO
&,17(6,6&HQWHUIRU5HVHDUFKLQ+HDOWK7HFKQRORJLHVDQG,QIRUPDWLRQ6 VWHPV8QLYHUVLW RI
3RUWR3RUWXJDO
3UHQ OQDULQJHQLQ31LVDSRO SKHQRODQGDSRZHUIXOSK WRHVWURJHQZLWKDELQGLQJDIILQLW 
WR HVWURJHQ UHFHSWRUV DOSKD (5 Į WKUHH WLPHV KLJKHU WKDQ (5ȕ >@ ȕHVWUDGLRO VWLPXODWHV
DQJLRJHQHVLV>@5HFHQWZRUNKDVDWWULEXWHGDQJLRJHQLFSURSHUWLHVWR31>@EXWLWVHIIHFWRQ
WKHPRGXODWLRQRIDQJLRJHQLFSURFHVVLV QRWFRQVLVWHQW
:HDLPHGWRHYDOXDWHWKHHIIHFWRI31RQDQJLRJHQLFSDWKZD VDQGYHULI WKHGHSHQGHQFHRQ
WKHDFWLYDWLRQRIWKH(5
+XPDQ XPELOLFDO YHLQ HQGRWKHOLDO FHOOV +89(& ZHUH VWLPXODWHG ZLWK YDVFXODU HQGRWKHOLDO
JURZWK IDFWRU 9(*) DQG WUHDWHG ZLWK 0 31 LQ WKH DEVHQFH RU SUHVHQFH RI DQ (5Į
DQWDJRQLVW033RUDQ(5ȕDQWDJRQLVW3+733(5ĮDQG(5ȕJHQHH[SUHVVLRQZDVHYDOXDWHG
E 573&59(*)5S$NWS(5.DQG7LHH[SUHVVLRQZDVTXDQWLILHGE ZHVWHUQEORWWLQJ
$QJ ZDV HYDOXDWHG E  (/,6$ DVVD  7KH PRGXODWLRQ RI DQJLRJHQLF SDWKZD V E  31 ZDV
FRQILUPHG LQ YLWUR E  TXDQWLILFDWLRQ RI WXEXODU VWUXFWXUHV IRUPHG E  +89(& FXOWLYDWHG LQ
PDWULJHO4XDQWLILFDWLRQVDUHH[SUHVVHGDVPHDQ6(06DPSOHVZHUHHYDOXDWHGE $129$
IROORZHGE %RQIHUURQL$GLIIHUHQFHEHWZHHQH[SHULPHQWDOJURXSVZDVFRQVLGHUHGVLJQLILFDQW
ZKHQHYHUS
+89(& RQO  WUDQVFULEHG (5ȕ 31 LQFUHDVHG WKH H[SUHVVLRQ RI 9(*)5   
S$NW    S(5.    DQG WKH IRUPDWLRQ RI WXEXODU VWUXFWXUHV LQ D
SURFHVVGHSHQGHQWRQ(5ȕ31VWLPXODWHGWKHUHOHDVHRI$QJDQGH[SUHVVLRQ
RI 7LH    LQGHSHQGHQWO  RI (5ȕ 7KH PDWULJHO DVVD  VKRZHG D WHQGHQF  WR
LQFUHDVHWKHIRUPDWLRQRIWXEXODUVWUXFWXUHVDIWHUWUHDWPHQWZLWKWKLVSRO SKHQRO
7KHUHVXOWVVKRZHGWKDW31VHHPVWRKDYHSURDQJLRJHQLFSURSHUWLHVWKDWPD EHUHJXODWHGE 
ELQGLQJ WR (5ȕ ZKLFK FDQ EH LQWHUHVWLQJ FRQVLGHULQJ SDWKRORJLHV DVVRFLDWHG WR SRRU
DQJLRJHQHVLVDVP RFDUGLDOLVFKHPLDSHULSKHUDODUWHULDOGLVHDVHDQGQHXURORJLFDOGLVHDVHV
5HIHUHQFHV
>@ 6FKDHIHU 2 DQG 6FKOHXQLQJ :'  8-P enylna ingenin is a po en ERalpha selec i e
phy oes ogen p esen in hops and bee ,7KH-RXUQDORI6WHURLG%LRFKHPLVWU DQG0ROHFXODU%LRORJ 

>@*HQFHO9%DQG.KDOLO5$Vascula e ec s o phy oes ogens and al e na i e menopausal
ho mone he apy in ca dio ascula disease, 0LQL5HYLHZVLQ0HGLFLQDO&KHPLVWU 
>@ 1HJUDR 5 DQG 6RDUHV 5  Angiogenesis and in lamma ionsignaling a e a ge s o bee
polyphenols on ascula cells-&HOO%LRFKHP